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Cardiac Myosin

Other Cytoskeletal Signaling Related Inhibitors

HSP Kinesin Microtubule Associated Integrin PAK Dynamin MLCK TACC3 Gap-Junction Actin
Cat.No. Product Name Information Product Use Citations Product Validations
S9948 Danicamtiv (MYK-491)

A novel cardiac myosin activator that enhances cardiomyocyte contraction, Danicamtiv (MYK-491, SAR 440181) is also known by this designation.
bioRxiv, 2024, 2024.10.09.617269
J Am Heart Assoc, 2023, 12(20):e030682
S8861 MYK-461 (Mavacamten) Mavacamten (MYK-461, SAR439152) is a small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy (HCM), one of the most prevalent heritable cardiovascular disorders.
Eur Heart J, 2025, ehaf813
Circ Res, 2025, S1525-0016(25)00760-9.
Circulation, 2023, 147(25):1919-1932
E4662 CK-586 CK-586(CK-4021586) is an inhibitor of cardiac myosin used to treat obstructive hypertrophic cardiomyopathy (oHCM). It effectively reduces left ventricular outflow tract obstruction (LVOTO) in a dose-dependent manner.
E1016 Aficamten (CK-274)

Aficamten (CK-274, CK 3773274) is a novel cardiac myosin inhibitor that reduces myocardial contractility in vitro and in vivo with an IC50 of 1.4 μM.