Catalog No.S1229 Synonyms: F-ara-A (NSC 312887) Phosphate
Molecular Weight(MW): 365.21
Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
Cited by 10 Publications
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Imatinib mesylate (IM) in combination of F-AMP significantly inhibits Ki67 and c-KIT expression in GIST-T1 tumor xenografts. Tumors were collected on the day after the last treatment and were then subjected to H&E staining and immunohistochemical detection of Ki67, c-KIT, and cleaved caspase-3 expression. Representative images of H&E staining and immunohistochemical staining of Ki67, c-KIT, and cleaved caspase-3 in mice tumors. Arrows indicate the decrease in cellularity and the increase in stromal fibrosis. Magnification, x 400.
Mol Cancer Ther 2014 13(10), 2276-87. Fludarabine Phosphate purchased from Selleck.
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|Description||Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.|
Fludarabine Phosphate is converted to F-ara-ATP in cells and then incorporated into DNA in a self-limiting manner. Fludarabine Phosphate competes with dATP for incorporation into the A site of the extending DNA strand, which results in termination of DNA strand elongation. Human DNA polymerase α incorporates more Fludarabine Phosphate into DNA than polymerase δ. Fludarabine Phosphate completively inhibits DNA polymerase α and DNA polymerase δ with Ki of 1.1 μM and 1.3 μM, respectively. DNA polymerase δ is also able to excise the incorporated Fludarabine Phosphate from DNA in vitro. 
|In vivo||Fludarabine Phosphate is toxic for tumor-free mice. The maximum tolerated dose (LD10) Fludarabine Phosphate administered as a single dose is 234 mg/kg. The 50% lethal dose is 375 mg/kg. Fludarabine Phosphate administered as a single dose induces fewer number of cells surviving therapy in mice bearing P388 leukemia, accompanied by greater percentage of increase in life span (110%) and increased median survival time. |
|In vitro||DMSO||73 mg/mL (199.88 mM)|
|Water||2 mg/mL warmed (5.47 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||F-ara-A (NSC 312887) Phosphate|
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04106310||Not yet recruiting||Device: High-flux dialyzer|Device: Theranova dialyzer||End Stage Renal Failure on Dialysis||The University of Hong Kong|Baxter Healthcare Corporation||December 1 2019||Phase 4|
|NCT03878953||Not yet recruiting||Drug: rhPTH(1-84)||Chronic Hypoparathyroidism||Shire||October 30 2019||Phase 3|
|NCT03943537||Not yet recruiting||Drug: Intranasal Insulin||Psychosis|Schizophrenia|Schizo Affective Disorder|Bipolar I Disorder||Mclean Hospital||October 2019||Phase 2|
|NCT04118842||Not yet recruiting||Drug: Savolitinib|Drug: Rifampicin||Solid Tumors||AstraZeneca||October 7 2019||Phase 1|
|NCT04121910||Not yet recruiting||Drug: Savolitinib|Drug: Itraconazole||Solid Tumour||AstraZeneca|Parexel||October 31 2019||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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