Catalog No.S7437

For research use only.

Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.

Sal003 Chemical Structure

CAS No. 1164470-53-4

Purity & Quality Control

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Biological Activity

Description Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
eIF-2α phosphatase [1]
In vitro

Sal003 increases eIF2α phosphorylation status by blocking eIF2a phosphatases in cells. [1] In mouse embryonic fibroblasts (MEFs), Sal003 causes dissociation of polysomes by increasing eIF2a phosphorylation. Sal003 impairs late-long-term potentiation (L-LTP) in an ATF4-dependent mode in hippocampal slices from WT mice. [2] In addition, eIF2α phosphorylation by Sal003 also enhances apoptotic signaling induced by subtilase cytotoxin (SubAB). [3]

In vivo Sal003 impairs spatial long-term memory formation in rats. [2]

Protocol (from reference)

Animal Research:[2]
  • Animal Models: Rats (300–325g body weight).
  • Dosages: 2 μL of 20 μM
  • Administration: Intrahippocampal Injection

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 463.21


CAS No. 1164470-53-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C=C1)C=CC(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=C(C=C2)Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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