PTP Inhibitor I

Catalog No.S3696 Synonyms: α-Bromo-4-hydroxyacetophenone, 2-Bromo-4'-hydroxyacetophenone, 4-Hydroxyphenacyl bromide, 4-Hydroxyphenacyl bromide, SHP-1 Inhibitor II

PTP Inhibitor I Chemical Structure

Molecular Weight(MW): 215.04

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.

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Choose Selective phosphatase Inhibitors

Biological Activity

Description PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.
Targets
PTP1B [1]
(Cell-free assay)
SHP-1(ΔSH2) [1]
(Cell-free assay)
42 μM(Ki) 43 μM(Ki)
In vitro

PTP Inhibitor I binds to PTPs with the highest affinity, having Ki values of 43 and 42 μM and Kinact values of 0.40 and 0.57/min for SHP-1(△SH2) and PTP1B, respectively. It has lower affinity to wild-type SHP-1 than its catalytic domain (K= 530 vs 43 μM), likely due to the fact that the SH2 domains can directly bind to the PTP active site and interfere with substrate/inhibitor binding[1].

Protocol

Cell Research:[1]
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  • Cell lines: human B cells
  • Concentrations: 30, 100, 300, 1000 μM
  • Incubation Time: 3 mins
  • Method: After incubation with varying concentrations of PTP Inhibitor I for 3 min, the cells are lysed, and the cellular proteins are separated on an SDS-PAGE gel, followed by western blot analysis.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 43 mg/mL (199.96 mM)
Ethanol 43 mg/mL (199.96 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 215.04
Formula

C8H7BrO2

CAS No. 2491-38-5
Storage powder
in solvent
Synonyms α-Bromo-4-hydroxyacetophenone, 2-Bromo-4'-hydroxyacetophenone, 4-Hydroxyphenacyl bromide, 4-Hydroxyphenacyl bromide, SHP-1 Inhibitor II

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID