PPP-family Selective Inhibitors

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S7573	GSK2830371	GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.	Selective	Wip1 phosphatase, IC50: 6 nM
S0744	Raphin1 acetate	Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM.	Selective	R15B-PP1c, Kd: 0.033 μM
S0528	Raphin1	Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.	Selective	R15B-PP1c, Kd: 33 nM
S5452	Sanguinarine chloride	Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.	Selective	PP2C, Ki: 0.68 μM
S7485	CCT007093	CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.	Selective	PPM1D, IC50: 8.4 μM
S7437	Sal003	Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.	Selective