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Reverse Transcriptase Products

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  • New Reverse Transcriptase Products
Catalog No. Product Name Information Product Use Citations Product Validations
S1252 Entecavir Hydrate Entecavir Hydrate (ETV, Baraclude), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).
Virology, 2021, 560:66-75
Viruses, 2021, 13(4)648
Adv Virol, 2020, 2020:8844061
S1398 Stavudine (d4T) Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
Cell Commun Signal, 2020, 18(1):150
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
Front Microbiol, 2018, 9:278
S1400 Tenofovir (GS 1278) Disoproxil Fumarate Tenofovir Disoproxil Fumarate (GS-1278, Tenofovir DF) belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.
J Virol, 2021, JVI.01777-20
Antiviral Res, 2021, 197:105211
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S1401 Tenofovir Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.
Antiviral Res, 2021, S0166-3542(21)00068-1
PLoS Pathog, 2020, 16(12):e1009024
Cells, 2020, 17;9(4) pii: E1003
S1651 Telbivudine Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.
Oncotarget, 2017, 8(15):24694-24705
Sci Rep, 2013, 3:2105
S1702 Didanosine Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
PLoS One, 2018, 13(3):e0194611
Cancer Cell, 2017, 32(2):221-237
S1704 Emtricitabine (BW 1592) Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.
J Virol, 2021, JVI.01777-20
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
JCI Insight, 2019, 4(12)
S1706 Lamivudine (BCH-189) Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.
Front Cardiovasc Med, 2021, 8:634774
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
Antiviral Res, 2020, 175:104709
S1718 Adefovir Dipivoxil (GS 0840) Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).
Front Immunol, 2020, 11:616570
Oncol Lett, 2018, 15(5):6107-6114
Sci Rep, 2017, 7:46344
S1719 Zalcitabine Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).
Front Cell Dev Biol, 2021, 9:698679
Autophagy, 2020, 18;1-13
Front Cell Dev Biol, 2019, 7:204
S1742 Nevirapine (NSC 641530) Nevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
J Cheminform, 2021, 13(1):90
J Int AIDS Soc, 2019, 22(12):e25425
Antimicrob Agents Chemother, 2019, 63(8)
S2579 Zidovudine Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency.
PLoS Pathog, 2020, 16;16(3):e1008341
Cells, 2020, 17;9(4) pii: E1003
Cells, 2020, 9(4)E1003
S2914 Dapivirine (TMC120) Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.
PLoS Pathog, 2020, 16(12):e1009024
Antimicrob Agents Chemother, 2019, 64(1)
Future Med Chem, 2019, 11(23):3005-3013
S3076 Foscarnet Sodium Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.
Front Cell Infect Microbiol, 2020, 10:536150
Neuron, 2017, 96(6):1290-1302
S3080 Etravirine (TMC125) Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
Front Cell Dev Biol, 2019, 7:204
J Virol, 2019, 93(9)
J Antimicrob Chemother, 2018, 73(10):2721-2728
S3165 Abacavir sulfate Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
J Virol, 2021, JVI.02305-20
Front Cardiovasc Med, 2021, 8:634774
Invest Ophthalmol Vis Sci, 2015, 56(12):7122-9
S3273 Hypericin Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).
Eur J Pharmacol, 2021, 900:174071
S3606 Fangchinoline Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.
S4187 Salicylanilide Salicylanilides (WR10019) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.
Hum Mol Genet, 2020, ddaa244
S4427New Tenofovir alafenamide hemifumarate Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Front Microbiol, 2018, 9:278
S4428New Tenofovir alafenamide fumarate Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Cells, 2021, 10(9)2321
Front Microbiol, 2018, 9:278
S4685 Efavirenz Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.
J Cheminform, 2021, 13(1):90
Cell Commun Signal, 2020, 18(1):150
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S4879New Tenofovir hydrate Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.
Cells, 2020, 9(4)E1003
S4890 Bifendate Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.
S5068 Adefovir Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
S5215 Abacavir (1592U89) Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
J Virol, 2021, JVI.02305-20
Front Cardiovasc Med, 2021, 8:634774
Antiviral Res, 2017, 142:123-135
S5246 Entecavir Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).
Antiviral Res, 2021, 197:105211
Antiviral Res, 2021, S0166-3542(21)00068-1
Virology, 2021, 560:66-75
S5423 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.
S5959New Tenofovir Disoproxil Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.
Front Microbiol, 2018, 9:278
S6452 Delavirdine (mesylate) Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.
J Cheminform, 2021, 13(1):90
S6492 Doravirine (MK-1439) Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities.
S6848 3'-Fluoro-3'-deoxythymidine (Alovudine) 3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
S7303 Rilpivirine Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.
Int J Pharm, 2021, 605:120844
Oncogene, 2020, 10.1038/s41388-020-01549-9
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S7856 Tenofovir Alafenamide (GS-7340) Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
Antiviral Res, 2021, 197:105211
Proc Natl Acad Sci U S A, 2020, 14;202002392
PLoS Pathog, 2020, 16(12):e1009024
S8055 Lersivirine (UK-453061) Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM.
S1252 Entecavir Hydrate Entecavir Hydrate (ETV, Baraclude), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).
Virology, 2021, 560:66-75
Viruses, 2021, 13(4)648
Adv Virol, 2020, 2020:8844061
S1398 Stavudine (d4T) Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
Cell Commun Signal, 2020, 18(1):150
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
Front Microbiol, 2018, 9:278
S1400 Tenofovir (GS 1278) Disoproxil Fumarate Tenofovir Disoproxil Fumarate (GS-1278, Tenofovir DF) belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.
J Virol, 2021, JVI.01777-20
Antiviral Res, 2021, 197:105211
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S1401 Tenofovir Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.
Antiviral Res, 2021, S0166-3542(21)00068-1
PLoS Pathog, 2020, 16(12):e1009024
Cells, 2020, 17;9(4) pii: E1003
S1651 Telbivudine Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.
Oncotarget, 2017, 8(15):24694-24705
Sci Rep, 2013, 3:2105
S1702 Didanosine Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
PLoS One, 2018, 13(3):e0194611
Cancer Cell, 2017, 32(2):221-237
S1704 Emtricitabine (BW 1592) Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.
J Virol, 2021, JVI.01777-20
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
JCI Insight, 2019, 4(12)
S1706 Lamivudine (BCH-189) Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.
Front Cardiovasc Med, 2021, 8:634774
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
Antiviral Res, 2020, 175:104709
S1718 Adefovir Dipivoxil (GS 0840) Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).
Front Immunol, 2020, 11:616570
Oncol Lett, 2018, 15(5):6107-6114
Sci Rep, 2017, 7:46344
S1719 Zalcitabine Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).
Front Cell Dev Biol, 2021, 9:698679
Autophagy, 2020, 18;1-13
Front Cell Dev Biol, 2019, 7:204
S1742 Nevirapine (NSC 641530) Nevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
J Cheminform, 2021, 13(1):90
J Int AIDS Soc, 2019, 22(12):e25425
Antimicrob Agents Chemother, 2019, 63(8)
S2579 Zidovudine Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency.
PLoS Pathog, 2020, 16;16(3):e1008341
Cells, 2020, 17;9(4) pii: E1003
Cells, 2020, 9(4)E1003
S2914 Dapivirine (TMC120) Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.
PLoS Pathog, 2020, 16(12):e1009024
Antimicrob Agents Chemother, 2019, 64(1)
Future Med Chem, 2019, 11(23):3005-3013
S3076 Foscarnet Sodium Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.
Front Cell Infect Microbiol, 2020, 10:536150
Neuron, 2017, 96(6):1290-1302
S3080 Etravirine (TMC125) Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
Front Cell Dev Biol, 2019, 7:204
J Virol, 2019, 93(9)
J Antimicrob Chemother, 2018, 73(10):2721-2728
S3165 Abacavir sulfate Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
J Virol, 2021, JVI.02305-20
Front Cardiovasc Med, 2021, 8:634774
Invest Ophthalmol Vis Sci, 2015, 56(12):7122-9
S3273 Hypericin Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).
Eur J Pharmacol, 2021, 900:174071
S3606 Fangchinoline Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.
S4187 Salicylanilide Salicylanilides (WR10019) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.
Hum Mol Genet, 2020, ddaa244
S4427New Tenofovir alafenamide hemifumarate Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Front Microbiol, 2018, 9:278
S4428New Tenofovir alafenamide fumarate Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Cells, 2021, 10(9)2321
Front Microbiol, 2018, 9:278
S4685 Efavirenz Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.
J Cheminform, 2021, 13(1):90
Cell Commun Signal, 2020, 18(1):150
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S4879New Tenofovir hydrate Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.
Cells, 2020, 9(4)E1003
S4890 Bifendate Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.
S5068 Adefovir Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
S5215 Abacavir (1592U89) Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
J Virol, 2021, JVI.02305-20
Front Cardiovasc Med, 2021, 8:634774
Antiviral Res, 2017, 142:123-135
S5246 Entecavir Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).
Antiviral Res, 2021, 197:105211
Antiviral Res, 2021, S0166-3542(21)00068-1
Virology, 2021, 560:66-75
S5423 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.
S5959New Tenofovir Disoproxil Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.
Front Microbiol, 2018, 9:278
S6452 Delavirdine (mesylate) Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.
J Cheminform, 2021, 13(1):90
S6492 Doravirine (MK-1439) Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities.
S6848 3'-Fluoro-3'-deoxythymidine (Alovudine) 3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
S7303 Rilpivirine Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.
Int J Pharm, 2021, 605:120844
Oncogene, 2020, 10.1038/s41388-020-01549-9
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S7856 Tenofovir Alafenamide (GS-7340) Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
Antiviral Res, 2021, 197:105211
Proc Natl Acad Sci U S A, 2020, 14;202002392
PLoS Pathog, 2020, 16(12):e1009024
S8055 Lersivirine (UK-453061) Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM.
S4427New Tenofovir alafenamide hemifumarate Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Front Microbiol, 2018, 9:278
S4428New Tenofovir alafenamide fumarate Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Cells, 2021, 10(9)2321
Front Microbiol, 2018, 9:278
S4879New Tenofovir hydrate Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.
Cells, 2020, 9(4)E1003
S5959New Tenofovir Disoproxil Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.
Front Microbiol, 2018, 9:278
Tags: reverse transcriptase inhibition | reverse transcriptase reaction | hiv reverse transcriptase | reverse transcriptase protocol | reverse transcriptase function | reverse transcriptase assay | reverse transcriptase activity | reverse transcriptase drugs | reverse transcriptase mechanism | reverse transcriptase in humans | reverse transcriptase inhibitor review