Reverse Transcriptase
Signaling Pathway Map
Research Area
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S1401 | Tenofovir | 2 mg/mL | 4 mg/mL | <1 mg/mL |
| S1400 | Tenofovir Disoproxil Fumarate | <1 mg/mL | 100 mg/mL | 44 mg/mL |
| S1704 | Emtricitabine | 49 mg/mL | 49 mg/mL | 9 mg/mL |
| S1252 | Entecavir Hydrate | <1 mg/mL | 59 mg/mL | <1 mg/mL |
| S1718 | Adefovir Dipivoxil | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S5068 | Adefovir | 0.1 mg/mL | <1 mg/mL | <1 mg/mL |
| S5423 | 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride | -1 mg/mL | 52 mg/mL | -1 mg/mL |
| S5246 | Entecavir | <1 mg/mL | 55 mg/mL | <1 mg/mL |
| S5215 | Abacavir | -1 mg/mL | 57 mg/mL | -1 mg/mL |
| S4890 | Bifendate | -1 mg/mL | 83 mg/mL | -1 mg/mL |
| S3606 | Fangchinoline | <1 mg/mL | 100 mg/mL | 4 mg/mL |
| S1742 | Nevirapine | <1 mg/mL | 53 mg/mL | <1 mg/mL |
| S1702 | Didanosine | <1 mg/mL | 47 mg/mL | <1 mg/mL |
| S1706 | Lamivudine | 46 mg/mL | 46 mg/mL | <1 mg/mL |
| S1398 | Stavudine (d4T) | <1 mg/mL | 45 mg/mL | 15 mg/mL |
| S1651 | Telbivudine | 48 mg/mL | 48 mg/mL | 2 mg/mL |
| S3080 | Etravirine (TMC125) | <1 mg/mL | 42 mg/mL | <1 mg/mL |
| S2579 | Zidovudine | 53 mg/mL | 53 mg/mL | 18 mg/mL |
| S1719 | Zalcitabine | 42 mg/mL | 7 mg/mL | <1 mg/mL |
| S3165 | Abacavir sulfate | 36 mg/mL | <1 mg/mL | <1 mg/mL |
| S2914 | Dapivirine (TMC120) | <1 mg/mL | 34 mg/mL | <1 mg/mL |
| S3076 | Foscarnet Sodium | 3 mg/mL | 7 mg/mL | <1 mg/mL |
| S7303 | Rilpivirine | <1 mg/mL | 73 mg/mL | <1 mg/mL |
| S4187 | Salicylanilide | <1 mg/mL | 43 mg/mL | 18 mg/mL |
| S4685 | Efavirenz | <1 mg/mL | 63 mg/mL | 63 mg/mL |
| S7856 | Tenofovir Alafenamide (GS-7340) | <1 mg/mL | 95 mg/mL | 95 mg/mL |
- Reverse Transcriptase Inhibitors (26)
- New Reverse Transcriptase Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1401 |
TenofovirTenofovir blocks reverse transcriptase and hepatitis B virus infections. |
The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; **** p<0.0001; *** p<0.001 (unpaired t-test). |
|
| S1400 |
Tenofovir Disoproxil FumarateTenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination. |
Human PBMCs containing indicated concentrations of Tenofovir disoproxil fumarate were inoculated with 5 ng mock-exposed or semen-exposed R5-HIV-luciferase, or 50 ng R5-HIV-luciferase as infectivity matched control. Infection rates were determined 3 days post inoculation.
|
|
| S1704 |
EmtricitabineEmtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h. |
||
| S1252 |
Entecavir HydrateEntecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
||
| S1718 |
Adefovir DipivoxilAdefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV). |
||
| S5068New |
AdefovirAdefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection. |
||
| S5423New |
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor. |
||
| S5246New |
EntecavirEntecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
||
| S5215New |
AbacavirAbacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. |
||
| S4890New |
BifendateBifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B. |
||
| S3606New |
FangchinolineFangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities. |
||
| S1742 |
NevirapineNevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. |
Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 d post infection by measuring β-galactosidase. Left: the mean enzyme activities. Middle: normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of nevirapine were set at 100%. Right: IC50 values.
|
|
| S1702 |
DidanosineDidanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. |
||
| S1706 |
LamivudineLamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. |
The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.
|
|
| S1398 |
Stavudine (d4T)Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. |
||
| S1651 |
TelbivudineTelbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection. |
||
| S3080 |
Etravirine (TMC125)Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. |
||
| S2579 |
ZidovudineZidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency. |
||
| S1719 |
ZalcitabineZalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
||
| S3165 |
Abacavir sulfateAbacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. |
||
| S2914 |
Dapivirine (TMC120)Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3. |
||
| S3076 |
Foscarnet SodiumFoscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs. |
||
| S7303 |
RilpivirineRilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection. |
||
| S4187 |
SalicylanilideSalicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities. |
||
| S4685 |
EfavirenzEfavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. |
||
| S7856 |
Tenofovir Alafenamide (GS-7340)Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B. |
