Reverse Transcriptase

Signaling Pathway Map

Research Area

Inhibitory Selectivity

Isoform-specific Inhibitors

Reverse Transcriptase Products

Catalog No. Information Product Use Citations Product Validations
S1401

Tenofovir

Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.

S1400

Tenofovir (GS 1278) Disoproxil Fumarate

Tenofovir Disoproxil Fumarate (GS-1278, Tenofovir DF) belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.

S1704

Emtricitabine (BW 1592)

Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.

S1252

Entecavir Hydrate

Entecavir Hydrate (ETV, Baraclude), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S1718

Adefovir Dipivoxil (GS 0840)

Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

S5959New

Tenofovir Disoproxil

Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.

S4879New

Tenofovir hydrate

Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.

S4427New

Tenofovir alafenamide hemifumarate

Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

S4428New

Tenofovir alafenamide fumarate

Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

S3273New

Hypericin

Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).

S6848New

3'-Fluoro-3'-deoxythymidine (Alovudine)

3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.

S1742

Nevirapine (NSC 641530)

Nevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

S1702

Didanosine

Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

S1706

Lamivudine (BCH-189)

Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

S1398

Stavudine (d4T)

Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

S1651

Telbivudine

Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.

S3080

Etravirine (TMC125)

Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

S2579

Zidovudine

Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency.

S1719

Zalcitabine

Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

S3165

Abacavir sulfate

Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

S2914

Dapivirine (TMC120)

Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.

S3076

Foscarnet Sodium

Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.

S7303

Rilpivirine

Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.

S4890

Bifendate

Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.

S5215

Abacavir (1592U89)

Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.

S5246

Entecavir

Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S4187

Salicylanilide

Salicylanilides (WR10019) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.

S4685

Efavirenz

Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

S3606

Fangchinoline

Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.

S6452

Delavirdine (mesylate)

Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.

S7856

Tenofovir Alafenamide (GS-7340)

Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

S8055

Lersivirine (UK-453061)

Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM.

S5423

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.

S5068

Adefovir

Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.

S6492

Doravirine (MK-1439)

Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities.

Catalog No. Information Product Use Citations Product Validations
S1401

Tenofovir

Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.

S1400

Tenofovir (GS 1278) Disoproxil Fumarate

Tenofovir Disoproxil Fumarate (GS-1278, Tenofovir DF) belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.

S1704

Emtricitabine (BW 1592)

Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.

S1252

Entecavir Hydrate

Entecavir Hydrate (ETV, Baraclude), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S1718

Adefovir Dipivoxil (GS 0840)

Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

S5959New

Tenofovir Disoproxil

Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.

S4879New

Tenofovir hydrate

Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.

S4427New

Tenofovir alafenamide hemifumarate

Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

S4428New

Tenofovir alafenamide fumarate

Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

S3273New

Hypericin

Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).

S6848New

3'-Fluoro-3'-deoxythymidine (Alovudine)

3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.

S1742

Nevirapine (NSC 641530)

Nevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

S1702

Didanosine

Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

S1706

Lamivudine (BCH-189)

Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

S1398

Stavudine (d4T)

Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

S1651

Telbivudine

Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.

S3080

Etravirine (TMC125)

Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

S2579

Zidovudine

Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency.

S1719

Zalcitabine

Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

S3165

Abacavir sulfate

Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

S2914

Dapivirine (TMC120)

Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.

S3076

Foscarnet Sodium

Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.

S7303

Rilpivirine

Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.

S4890

Bifendate

Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.

S5215

Abacavir (1592U89)

Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.

S5246

Entecavir

Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S4187

Salicylanilide

Salicylanilides (WR10019) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.

S4685

Efavirenz

Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

S3606

Fangchinoline

Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.

S6452

Delavirdine (mesylate)

Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.

S7856

Tenofovir Alafenamide (GS-7340)

Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

S8055

Lersivirine (UK-453061)

Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM.

S5423

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.

S5068

Adefovir

Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.

S6492

Doravirine (MK-1439)

Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities.

Tags: reverse transcriptase inhibition | reverse transcriptase reaction | hiv reverse transcriptase | reverse transcriptase protocol | reverse transcriptase function | reverse transcriptase assay | reverse transcriptase activity | reverse transcriptase drugs | reverse transcriptase mechanism | reverse transcriptase in humans | reverse transcriptase inhibitor review