E0815New |
Rilpivirine Hydrochloride
|
Rilpivirine (TMC278), is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz. |
|
|
S1252 |
Entecavir Hydrate
|
Entecavir Hydrate (ETV, Baraclude), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
-
Cancer Discov, 2022, candisc.1117.2021
-
Virology, 2021, 560:66-75
-
Viruses, 2021, 13(4)648
|
|
S1398 |
Stavudine (d4T)
|
Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. |
-
Cancer Discov, 2022, candisc.1117.2021
-
Cell Commun Signal, 2020, 18(1):150
-
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
|
|
S1400 |
Tenofovir (GS 1278) Disoproxil Fumarate
|
Tenofovir Disoproxil Fumarate (GS-1278, Tenofovir DF) belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination. |
-
Sci Rep, 2022, 12(1):2966
-
J Virol, 2022, JVI0173021
-
Virol Sin, 2022, S1995-820X(22)00081-5
|
|
S1401 |
Tenofovir
|
Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
-
Cancer Discov, 2022, candisc.1117.2021
-
Antiviral Res, 2022, 203:105348
-
Antiviral Res, 2021, S0166-3542(21)00068-1
|
|
S1651 |
Telbivudine
|
Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection. |
-
Oncotarget, 2017, 8(15):24694-24705
-
Sci Rep, 2013, 3:2105
|
|
S1702 |
Didanosine
|
Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. |
-
PLoS One, 2018, 13(3):e0194611
-
Cancer Cell, 2017, 32(2):221-237
|
|
S1704 |
Emtricitabine (BW 1592)
|
Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h. |
-
Cancer Discov, 2022, candisc.1117.2021
-
J Virol, 2022, JVI0173021
-
J Virol, 2021, JVI.01777-20
|
|
S1706 |
Lamivudine (BCH-189)
|
Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. |
-
Cancer Discov, 2022, candisc.1117.2021
-
J Virol, 2022, JVI0173021
-
Front Cardiovasc Med, 2021, 8:634774
|
|
S1718 |
Adefovir Dipivoxil (GS 0840)
|
Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV). |
-
Front Immunol, 2020, 11:616570
-
Oncol Lett, 2018, 15(5):6107-6114
-
Sci Rep, 2017, 7:46344
|
|
S1719 |
Zalcitabine
|
Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
-
Cancer Discov, 2022, candisc.1117.2021
-
Arch Toxicol, 2022, 1-20
-
Toxicol Lett, 2022, 362:50-58
|
|
S1742 |
Nevirapine (NSC 641530)
|
Nevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. |
-
J Virol, 2022, JVI0173021
-
Biochem Pharmacol, 2021, 197:114901
-
J Cheminform, 2021, 13(1):90
|
|
S2579 |
Zidovudine
|
Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency. |
-
Cancer Discov, 2022, candisc.1117.2021
-
J Virol, 2022, JVI0173021
-
Biochem Pharmacol, 2021, 197:114901
|
|
S2914 |
Dapivirine (TMC120)
|
Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3. |
-
PLoS Pathog, 2020, 16(12):e1009024
-
Antimicrob Agents Chemother, 2019, 64(1)
-
Future Med Chem, 2019, 11(23):3005-3013
|
|
S3076 |
Foscarnet Sodium
|
Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs. |
-
Front Cell Infect Microbiol, 2020, 10:536150
-
Neuron, 2017, 96(6):1290-1302
|
|
S3080 |
Etravirine (TMC125)
|
Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. |
-
Front Cell Dev Biol, 2019, 7:204
-
J Virol, 2019, 93(9)
-
J Antimicrob Chemother, 2018, 73(10):2721-2728
|
|
S3165 |
Abacavir sulfate
|
Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. |
-
Cancer Discov, 2022, candisc.1117.2021
-
J Virol, 2021, JVI.02305-20
-
Front Cardiovasc Med, 2021, 8:634774
|
|
S3273 |
Hypericin
|
Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
-
Eur J Pharmacol, 2021, 900:174071
|
|
S3606 |
Fangchinoline
|
Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.
|
|
|
S4187 |
Salicylanilide
|
Salicylanilides (WR10019) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities. |
-
Hum Mol Genet, 2020, ddaa244
|
|
S4427 |
Tenofovir alafenamide hemifumarate
|
Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. |
-
Front Microbiol, 2018, 9:278
|
|
S4428 |
Tenofovir alafenamide fumarate
|
Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. |
-
Cells, 2021, 10(9)2321
-
Front Microbiol, 2018, 9:278
|
|
S4685 |
Efavirenz
|
Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. |
-
Nat Commun, 2022, 13(1):1121
-
J Cheminform, 2021, 13(1):90
-
Cell Commun Signal, 2020, 18(1):150
|
|
S4879 |
Tenofovir hydrate
|
Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections. |
-
Cancer Discov, 2022, candisc.1117.2021
-
Cells, 2020, 9(4)E1003
|
|
S4890 |
Bifendate
|
Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B. |
|
|
S5068 |
Adefovir
|
Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection. |
|
|
S5215 |
Abacavir (1592U89)
|
Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. |
-
Cancer Discov, 2022, candisc.1117.2021
-
J Virol, 2021, JVI.02305-20
-
Front Cardiovasc Med, 2021, 8:634774
|
|
S5246 |
Entecavir
|
Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
-
Cancer Discov, 2022, candisc.1117.2021
-
Toxicol Lett, 2022, 362:50-58
-
Virol Sin, 2022, S1995-820X(22)00062-1
|
|
S5423 |
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride
|
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor. |
|
|
S5959 |
Tenofovir Disoproxil
|
Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain. |
-
J Virol, 2022, JVI0173021
-
Front Microbiol, 2018, 9:278
|
|
S6452 |
Delavirdine (mesylate)
|
Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor. |
-
J Cheminform, 2021, 13(1):90
|
|
S6492 |
Doravirine (MK-1439)
|
Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities. |
|
|
S6848 |
3'-Fluoro-3'-deoxythymidine (Alovudine)
|
3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. |
|
|
S7303 |
Rilpivirine
|
Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection. |
-
J Virol, 2022, JVI0173021
-
Int J Pharm, 2021, 605:120844
-
Oncogene, 2020, 10.1038/s41388-020-01549-9
|
|
S7856 |
Tenofovir Alafenamide (GS-7340)
|
Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
|
-
Antiviral Res, 2021, 197:105211
-
Proc Natl Acad Sci U S A, 2020, 14;202002392
-
PLoS Pathog, 2020, 16(12):e1009024
|
|
S8055 |
Lersivirine (UK-453061)
|
Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM. |
|
|
E0815New |
Rilpivirine Hydrochloride
|
Rilpivirine (TMC278), is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz. |
|
|
S1252 |
Entecavir Hydrate
|
Entecavir Hydrate (ETV, Baraclude), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
- Cancer Discov, 2022, candisc.1117.2021
- Virology, 2021, 560:66-75
- Viruses, 2021, 13(4)648
|
|
S1398 |
Stavudine (d4T)
|
Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. |
- Cancer Discov, 2022, candisc.1117.2021
- Cell Commun Signal, 2020, 18(1):150
- ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
|
|
S1400 |
Tenofovir (GS 1278) Disoproxil Fumarate
|
Tenofovir Disoproxil Fumarate (GS-1278, Tenofovir DF) belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination. |
- Sci Rep, 2022, 12(1):2966
- J Virol, 2022, JVI0173021
- Virol Sin, 2022, S1995-820X(22)00081-5
|
|
S1401 |
Tenofovir
|
Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
- Cancer Discov, 2022, candisc.1117.2021
- Antiviral Res, 2022, 203:105348
- Antiviral Res, 2021, S0166-3542(21)00068-1
|
|
S1651 |
Telbivudine
|
Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection. |
- Oncotarget, 2017, 8(15):24694-24705
- Sci Rep, 2013, 3:2105
|
|
S1702 |
Didanosine
|
Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. |
- PLoS One, 2018, 13(3):e0194611
- Cancer Cell, 2017, 32(2):221-237
|
|
S1704 |
Emtricitabine (BW 1592)
|
Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h. |
- Cancer Discov, 2022, candisc.1117.2021
- J Virol, 2022, JVI0173021
- J Virol, 2021, JVI.01777-20
|
|
S1706 |
Lamivudine (BCH-189)
|
Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. |
- Cancer Discov, 2022, candisc.1117.2021
- J Virol, 2022, JVI0173021
- Front Cardiovasc Med, 2021, 8:634774
|
|
S1718 |
Adefovir Dipivoxil (GS 0840)
|
Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV). |
- Front Immunol, 2020, 11:616570
- Oncol Lett, 2018, 15(5):6107-6114
- Sci Rep, 2017, 7:46344
|
|
S1719 |
Zalcitabine
|
Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
- Cancer Discov, 2022, candisc.1117.2021
- Arch Toxicol, 2022, 1-20
- Toxicol Lett, 2022, 362:50-58
|
|
S1742 |
Nevirapine (NSC 641530)
|
Nevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. |
- J Virol, 2022, JVI0173021
- Biochem Pharmacol, 2021, 197:114901
- J Cheminform, 2021, 13(1):90
|
|
S2579 |
Zidovudine
|
Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency. |
- Cancer Discov, 2022, candisc.1117.2021
- J Virol, 2022, JVI0173021
- Biochem Pharmacol, 2021, 197:114901
|
|
S2914 |
Dapivirine (TMC120)
|
Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3. |
- PLoS Pathog, 2020, 16(12):e1009024
- Antimicrob Agents Chemother, 2019, 64(1)
- Future Med Chem, 2019, 11(23):3005-3013
|
|
S3076 |
Foscarnet Sodium
|
Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs. |
- Front Cell Infect Microbiol, 2020, 10:536150
- Neuron, 2017, 96(6):1290-1302
|
|
S3080 |
Etravirine (TMC125)
|
Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. |
- Front Cell Dev Biol, 2019, 7:204
- J Virol, 2019, 93(9)
- J Antimicrob Chemother, 2018, 73(10):2721-2728
|
|
S3165 |
Abacavir sulfate
|
Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. |
- Cancer Discov, 2022, candisc.1117.2021
- J Virol, 2021, JVI.02305-20
- Front Cardiovasc Med, 2021, 8:634774
|
|
S3273 |
Hypericin
|
Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
- Eur J Pharmacol, 2021, 900:174071
|
|
S3606 |
Fangchinoline
|
Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.
|
|
|
S4187 |
Salicylanilide
|
Salicylanilides (WR10019) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities. |
- Hum Mol Genet, 2020, ddaa244
|
|
S4427 |
Tenofovir alafenamide hemifumarate
|
Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. |
- Front Microbiol, 2018, 9:278
|
|
S4428 |
Tenofovir alafenamide fumarate
|
Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. |
- Cells, 2021, 10(9)2321
- Front Microbiol, 2018, 9:278
|
|
S4685 |
Efavirenz
|
Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. |
- Nat Commun, 2022, 13(1):1121
- J Cheminform, 2021, 13(1):90
- Cell Commun Signal, 2020, 18(1):150
|
|
S4879 |
Tenofovir hydrate
|
Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections. |
- Cancer Discov, 2022, candisc.1117.2021
- Cells, 2020, 9(4)E1003
|
|
S4890 |
Bifendate
|
Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B. |
|
|
S5068 |
Adefovir
|
Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection. |
|
|
S5215 |
Abacavir (1592U89)
|
Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. |
- Cancer Discov, 2022, candisc.1117.2021
- J Virol, 2021, JVI.02305-20
- Front Cardiovasc Med, 2021, 8:634774
|
|
S5246 |
Entecavir
|
Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
- Cancer Discov, 2022, candisc.1117.2021
- Toxicol Lett, 2022, 362:50-58
- Virol Sin, 2022, S1995-820X(22)00062-1
|
|
S5423 |
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride
|
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor. |
|
|
S5959 |
Tenofovir Disoproxil
|
Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain. |
- J Virol, 2022, JVI0173021
- Front Microbiol, 2018, 9:278
|
|
S6452 |
Delavirdine (mesylate)
|
Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor. |
- J Cheminform, 2021, 13(1):90
|
|
S6492 |
Doravirine (MK-1439)
|
Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities. |
|
|
S6848 |
3'-Fluoro-3'-deoxythymidine (Alovudine)
|
3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. |
|
|
S7303 |
Rilpivirine
|
Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection. |
- J Virol, 2022, JVI0173021
- Int J Pharm, 2021, 605:120844
- Oncogene, 2020, 10.1038/s41388-020-01549-9
|
|
S7856 |
Tenofovir Alafenamide (GS-7340)
|
Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
|
- Antiviral Res, 2021, 197:105211
- Proc Natl Acad Sci U S A, 2020, 14;202002392
- PLoS Pathog, 2020, 16(12):e1009024
|
|
S8055 |
Lersivirine (UK-453061)
|
Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM. |
|
|