Reverse Transcriptase

Signaling Pathway Map

Research Area

Inhibitory Selectivity

Reverse Transcriptase Products

New Reverse Transcriptase Products
Catalog No. Information Product Use Citations Product Validations
S1401

Tenofovir

Tenofovir blocks reverse transcriptase and hepatitis B virus infections.

S1400

Tenofovir Disoproxil Fumarate

Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.

S1704

Emtricitabine

Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.

S1252

Entecavir Hydrate

Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S1718

Adefovir Dipivoxil

Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

S6492New

Doravirine (MK-1439)

Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities.

S6452New

Delavirdine (mesylate)

Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.

S1742

Nevirapine

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

S1702

Didanosine

Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

S1706

Lamivudine

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

S1398

Stavudine (d4T)

Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

S1651

Telbivudine

Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.

S3080

Etravirine (TMC125)

Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

S2579

Zidovudine

Zidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency.

S1719

Zalcitabine

Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

S3165

Abacavir sulfate

Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

S2914

Dapivirine (TMC120)

Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.

S3076

Foscarnet Sodium

Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.

S7303

Rilpivirine

Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.

S4890

Bifendate

Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.

S5215

Abacavir

Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.

S5246

Entecavir

Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S4187

Salicylanilide

Salicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.

S4685

Efavirenz

Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

S3606

Fangchinoline

Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.

S7856

Tenofovir Alafenamide (GS-7340)

Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

S5423

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.

S5068

Adefovir

Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.

Catalog No. Information Product Use Citations Product Validations
S1401

Tenofovir

Tenofovir blocks reverse transcriptase and hepatitis B virus infections.

S1400

Tenofovir Disoproxil Fumarate

Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.

S1704

Emtricitabine

Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.

S1252

Entecavir Hydrate

Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S1718

Adefovir Dipivoxil

Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

S6492New

Doravirine (MK-1439)

Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities.

S6452New

Delavirdine (mesylate)

Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.

S1742

Nevirapine

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

S1702

Didanosine

Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

S1706

Lamivudine

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

S1398

Stavudine (d4T)

Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

S1651

Telbivudine

Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.

S3080

Etravirine (TMC125)

Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

S2579

Zidovudine

Zidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency.

S1719

Zalcitabine

Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

S3165

Abacavir sulfate

Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

S2914

Dapivirine (TMC120)

Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.

S3076

Foscarnet Sodium

Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.

S7303

Rilpivirine

Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.

S4890

Bifendate

Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.

S5215

Abacavir

Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.

S5246

Entecavir

Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S4187

Salicylanilide

Salicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.

S4685

Efavirenz

Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

S3606

Fangchinoline

Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.

S7856

Tenofovir Alafenamide (GS-7340)

Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

S5423

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.

S5068

Adefovir

Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.

Tags: reverse transcriptase inhibition | reverse transcriptase reaction | hiv reverse transcriptase | reverse transcriptase protocol | reverse transcriptase function | reverse transcriptase assay | reverse transcriptase activity | reverse transcriptase drugs | reverse transcriptase mechanism | reverse transcriptase in humans | reverse transcriptase inhibitor review