Lamivudine (BCH-189)

Catalog No.S1706 Synonyms: GR109714X

For research use only.

Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

Lamivudine (BCH-189) Chemical Structure

CAS No. 134678-17-4

Selleck's Lamivudine (BCH-189) has been cited by 10 Publications

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Biological Activity

Description Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.
Targets
Reverse transcriptase [1]
In vitro

Lamivudine’s anti- HBV activity, like its anti-HIV activity, has been shown to depend on the ability of LMV-TP to serve as both substrate and inhibitor of the DNA- and RNA-dependent polymerase activities of the HBV P gene product. Lamivudine owes its activity to the remarkably broad substrate specificity of deoxycytidine kinase and the unusual substrate preference of the HBV polymerases for dNTPs with the unnatural L-conformation, whereas the anti-HBV activity of PCV appears to depend on several factors including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity) by key cellular enzymes, the long intracellular half-life of PCV-TP and the ability of PCV-TP to inhibit the HBV RT priming reaction as well as RT and DNA polymerase activity. [1] Lamivudine and Penciclovir inhibits duck hepatitis B virus (DHBV) replication to a comparable extent when used alone, and in combination, the two nucleoside analogs acts synergistically over a wide range of clinically relevant concentrations. Lamivudine combined with Penciclovir is more effective in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV than either drug alone. [2] Lamivudine inhibits p24 antigen production by HIV-I in PBMC, with ED50s ranging from 0.07 μM to 0.2 μM. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MT-4 MmP1SpVv[3Srb36gZZN{[Xl? NHj3dGdEd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgd5lvfGmlYTDmc5Ju[XSrb36gZpkhPTBnIHnuJGhKXi1zIHnu[oVkfGWmIF3UMVQh[2WubIOsJGlEPTB;MD6x{txO MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85ODN3NEK5K|45ODN3NEK5QE9iRg>?
PBMC NX;6RlZHTnWwY4Tpc44h[XO|YYm= NHHtb4tEd26lZX70doF1cW:wIILldZVqemWmIH\vdkBidnSrdnnyZYwh[WO2aY\peJkhcW5iUFLNR{ApcHWvYX6gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkBk\WyuczmgbY5n\WO2ZXSge4l1cCCKSW[tNUB{fHKjaX6gUGFXNCCHQ{WwQVAvODBzON88US=> M33ZT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh2MUC5O|UoRjh2MUC5O|U9N2F-
PBMC MXXGeY5kfGmxbjDhd5NigQ>? NUXhZZpCS2:wY3XueJJifGmxbjDy[ZF2cXKnZDDmc5Ih[W62aY\pdoFtKGGldHn2bZR6KGmwIGDCUWMhMGi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIh[2WubIOpJIlv\mWldHXkJJdqfGhiSFnWMVEhe3S{YXnuJGxCXixiRVO1NF0xNjJzzszN MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85PDFyOUe1K|45PDFyOUe1QE9iRg>?
PBMC NEj2NIRCdnSrLVjJWk0yKGG|c3H5 NXvJeYhqSW62aT3ITXYuOSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIhMFCETTmgZ4VtdHNiaX7m[YN1\WRid3n0bEBJUVZvMTDzeJJicW5iTFHWMEBGSzVyPUCuNFAyQM7:TR?= NHfNVGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NEKzOVkyLz56NEKzOVkyRC:jPh?=
PBMC MUDBcpRqNUiLVj2xJIF{e2G7 NGS1TppCdnSrLVjJWk0yKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkApWEKPKTDj[YxteyCrbn\lZ5Rm\CC5aYToJGhKXi1zIIP0doFqdiCOQW[sJGVEPTB;MD6wOu69VQ>? MmLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDR{M{W5NUc,QDR{M{W5NVww[T5?
PBMC M{jmZ2FvfGlvSFnWMVEh[XO|YYm= NGXyN3lCdnSrLVjJWk0yKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkApWEKPKTDj[YxteyCrbn\lZ5Rm\CC5aYToJGhKXi1zIIP0doFqdiCOQW[sJGVEPTB;MD6yNe69VQ>? M3\Z[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh2MkO1PVEoRjh2MkO1PVE9N2F-
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PBMC M16yb2FvfGlvSFnWMVEh[XO|YYm= MkHrTY4hfmm2cn:gZY51cS2KSW[gZYN1cX[rdImgbY4heGW{aYDo[ZJidCCkbH;v[EBud26xboXjcIVieiClZXzsd{whTUN3ME2wMlA4|ryP MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86OzBzNkW5K|46OzBzNkW5QE9iRg>?
2.2.15 MV\BcpRqfmm{YXygZZN{[Xl? MV3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZBifGm2aYOgRkB3cXK3czCoTGJXMSCrbjCyMlIvOTViY3XscJMtKEWFNUC9NE4xODkQvF2= Mnu5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyNUK3PVUoRjFzMEWyO|k2RC:jPh?=
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H9 NXOyW3ZTSW62aY\pdoFtKGG|c3H5 NUfmWFNuSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDSSkBqdiCqdX3hckBJQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYomg[o9zdWG8YX6tZoF{\WRiY3;ueoVvfGmxbnHsJINwdG:{aX3leJJq[yC2ZXPocolyfWVuIFXDOVA:OC5yNt88US=> NH;EU3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUSzNFAyQSd-MUG0N|AxOTl:L3G+
PBMC MYrBcpRqfmm{YXygZZN{[Xl? MnfpRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXNTG6eFLSWUBufXSjboSgd5Rz[WmwIHnuJIh2dWGwIGDCUUBk\WyuczygSWM6OD1yLkC4{txO M2\hclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{M{izNFE1Lz5zMkO4N|AyPDxxYU6=
PBMC NX7DOFl2TnWwY4Tpc44h[XO|YYm= NXO1cIhzSWO2aY\peJkh[WejaX7zeEBN[W2rdoXkbY5mNXKnc3nzeIFvfCC4aYL1d{ApUEmYLUHYXGJTXSliaX6gbJVu[W5iUFLNJINmdGy|LDDlfJBz\XO|ZXSgZZMhTUN3MDygSWM2OD1yLkCzOe69VQ>? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh3Mke1OUc,OTJ6NUK3OVU9N2F-
PBMC NIHQbo5HfW6ldHnvckBie3OjeR?= NVvDZWxbUW5idnn0do8h[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JJRp\SCKSW[tNUBNSTFicnXwcIlk[XSrb36gc44hWEKPQ4OgZ4VtdCBqcHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjDj[YxteyluIFXDOVA:OC5yMd88US=> MmnsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6NUK5OFMoRjF{OEWyPVQ{RC:jPh?=
PBMC M2r4R2Z2dmO2aX;uJIF{e2G7 MYjF[oZm[3SrdnWgZ49v[2WwdILheIlwdiC2bzDpcohq[mm2IFjJWk0yKEyDSTDjfZRweGG2aHnjbZR6KGmwIGDCUWMh[2WubIOge4F{KGSndHXycYlv\WRiaX6geol1em9uIFXDOVA:OC5yMUG2{txO NGrtR4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEm3NVg6QCd-MUS5O|E5QTh:L3G+
HepG2.2.15 Mn;1SpVv[3Srb36gZZN{[Xl? NWL3XXlOTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36geI8hcW6qaXLpeEBp\XCjdHn0bZMhSiC4aYL1d{BkgXSxcHH0bIlkcXS7IHnuJGhmeEd{LkKuNVUh[2WubIOge4F{KGSndHXycYlv\WRiaX6geol1em9uIFXDOVA:OC5{zszN NGPEfGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEm3NVg6QCd-MUS5O|E5QTh:L3G+
MT-4 Ml33SpVv[3Srb36gZZN{[Xl? M3rVVGVn\mWldHn2[UBkd26lZX70doF1cW:wIITvJIlvcGmkaYSgTGlXNTFiSVnJRkBkgXSxcHH0bIlkcXS7IHnuJG1VNTRiY3XscJMhf2G|IHTleIVzdWmwZXSgbY4hfmm2cn:sJGVEPTB;MD61{txO MoLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR7N{G4PVgoRjF2OUexPFk5RC:jPh?=
PBMC MXrBcpRqfmm{YXygZZN{[Xl? MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGlXKH[rcoXzLJh5SlKXKTDpckBJfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJEhRSk1rIHPlcIx{NCCHQ{mwQVAvODkQvF2= NYTnNXVDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwNlc5PTRpPkG1NFI4QDV2PD;hQi=>
PBMC M1W4OWZ2dmO2aX;uJIF{e2G7 NV3rS5VJTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gZYdicW6|dDDXbYxlKFS7cHWgTGlXNTFidnnyeZMhcW5iaIXtZY4heGW{aYDo[ZJidCCkbH;v[EBud26xboXjcIVieiClZXzsd{whTUN3ME2wMlA1Oc7:TR?= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTF6OUCzOkc,OTVzOEmwN|Y9N2F-
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2.2.15 M1PidmZ2dmO2aX;uJIF{e2G7 NX3J[YxJTW[oZXP0bZZmKGOxbnPlcpRz[XSrb37zJIF1KHeqaXPoJFExNW[xbHSg[IVxemW|c3nvckBw\iCrboTyZYNmdGy3bHHyJIlvfGW{bXXkbYF1\XNib3[gTGJXKESQQTD3ZZMhd2K|ZYL2[YQhcW5iMj6yMlE2KEOnbHzzMEBGSzlyPUCuOlnPxE1? MonjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZyM{OyPFMoRjF4MEOzNlg{RC:jPh?=
2.2.15 NUHqUlA{TnWwY4Tpc44h[XO|YYm= NWPCbpNpUW6qaXLpeIlwdiCxZjDzfY51cGW|aYOgc4Yh\Xi2cnHj[YxtfWyjcjD2bZJqd25iRF7BJJJmdGWjc3WgbY4h[3WudIXy[YQhcHWvYX6gbIVx[XSxYnzhd5RwdWFiMj6yMlE2KGOnbHzzMEBGSzVyPUCuNFQ5|ryP MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjJzM{exN{c,OTZ{MUO3NVM9N2F-
2.2.15 NHu2eZVHfW6ldHnvckBie3OjeR?= M4XvVWlvcGmkaYTpc44hd2Zic4nueIhme2m|IH;mJIV5fHKjY3XscJVt[XJidnnybY9vKESQQTDy[Yxm[XOnIHnuJIN2dHS3cnXkJIh2dWGwIHjldIF1d2KuYYP0c41iKDJwMj6xOUBk\WyuczygSWM6OD1yLkG1Ne69VQ>? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjJzM{exN{c,OTZ{MUO3NVM9N2F-
2.2.15 MkK3SpVv[3Srb36gZZN{[Xl? NGTMeo5KdmirYnn0bY9vKG:oIIP5cpRp\XOrczDv[kBqdnS{YXPlcIx2dGG{IFjCWkBFVkFicnXwcIlk[XSrdnWgbY51\XKvZXTpZZRmeyCrbjDjeYx1fXKnZDDoeY1idiCqZYDheI9jdGG|dH;tZUAzNjJwMUWgZ4VtdHNuIFXDOVA:OC5{NUJOwG0> NGnXbG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkKxN|cyOyd-MU[yNVM4OTN:L3G+
2.2.15 MlPxSpVv[3Srb36gZZN{[Xl? NYnqZmpQUW6qaXLpeIlwdiCxZjDzfY51cGW|aYOgc4YhcW62cnHj[YxtfWyjcjDIRnYhTE6DIILldIxq[2G2aY\lJIlvfGW{bXXkbYF1\XNiaX6gZ5VtfHW{ZXSgbJVu[W5iaHXwZZRw[myjc4TvcYEhOi5{LkG1JINmdGy|LDDFR|kxRTBwNkS4{txO NYLPd5prRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[yNVM4OTNpPkG2NlE{PzF|PD;hQi=>
2.2.15 NWO0WlkxTnWwY4Tpc44h[XO|YYm= NWrvcJE5UW6qaXLpeIlwdiCxZjD3bYxlKHS7cHWgTGJXKHS{YX7z[oVkfGWmIHnuJIh2dWGwIHjldIF1d2KuYYP0c41iKDJwMj6xOUBk\WyuczygSWM2OD1{LkJOwG0> NGPKbmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM6Oyd-MU[1N|k{QTN:L3G+
hepatoma 2.2.15 MmTNRY51cX[rcnHsJIF{e2G7 MnrPRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\CC2eYDlJGhDXiCrbjDoeY1idiCqZYDheI9u[SB{LkKuNVUh[2WubIOsJGVEPTB;Mj6x{txO Ml7sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5NUmxNVIoRjF4N{W5NVEzRC:jPh?=
2.2.15 M33lO2Z2dmO2aX;uJIF{e2G7 MWDJcohq[mm2aX;uJI9nKEiEVjDy[ZBtcWOjdHnvckBqdiB{LkKuNVUh[2WubIOgZpkhTE6DIHj5ZpJq\Gm8YYTpc44h[XO|YYmsJGVEPTB;MD6wNu69VQ>? MlrCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyMES3NlYoRjF5MEC0O|I3RC:jPh?=
MDCK2 MlXqSpVv[3Srb36gZZN{[Xl? MnHlNVAhfU1? MorBTY5pcWKrdHnvckBw\iCqdX3hckBOWlB{IHX4dJJme3OnZDDpckBOTEONMjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IFPNSkBndHWxcnXzZ4Vv[2ViYYSgNVAhfU1iYomgR21HTEFiYYPzZZk> NIrU[4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G3NlMyOSd-MUexO|I{OTF:L3G+
MDCK2 NWXlbHhWTnWwY4Tpc44h[XO|YYm= NV[4VpE2OTBidV2= NGT1ZXJKdmirYnn0bY9vKG:oIHj1cYFvKE2UUEOg[ZhxemW|c3XkJIlvKE2GQ1uyJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgR21HKG[udX;y[ZNk\W6lZTDheEAyOCC3TTDifUBEVU[GQTDhd5NigQ>? M3HDWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUeyN|EyLz5zN{G3NlMyOTxxYU6=
MDCK2 MlfTSpVv[3Srb36gZZN{[Xl? MYixNEB2VQ>? NIXObYVKdmirYnn0bY9vKG:oIHj1cYFvKE2UUEGg[ZhxemW|c3XkJIlvKE2GQ1uyJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgR21HKG[udX;y[ZNk\W6lZTDheEAyOCC3TTDifUBEVU[GQTDhd5NigQ>? NHvJb3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G3NlMyOSd-MUexO|I{OTF:L3G+
Huh7 MYHGeY5kfGmxbjDhd5NigQ>? MYHJcohq[mm2aX;uJI9nKHerbHSgeJlx\SCKQm[gdoVxdGmlYYTpc44hcW5iSIXoO{Bk\WyuczygSWM2OD1zzszN NEDJVog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O3NVgzPyd-MUezO|E5Ojd:L3G+
PBMC M33nXmFvfGm4aYLhcEBie3OjeR?= MV7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKEyDSTDpckBpfW2jbjDQRm0h[2WubIOsJGVEPTB;MD6wNlbPxE1? M4HCeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NECzPVk3Lz5zN{SwN|k6PjxxYU6=
PBMC Mm\hRY51cX[rcnHsJIF{e2G7 MXHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKEyDSTDpckBpfW2jbjDQRm0h[2WubIOsJGVEQTB;MD6xNu69VQ>? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRyM{m5Okc,OTd2MEO5PVY9N2F-
HepG2.2.15 NULwTFR2SW62aY\pdoFtKGG|c3H5 MnnrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwIFjldGczNjJwMUWgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h\Xi2cnHj[YxtfWyjcjD2bZJidCCGTlGgcIV3\WxiYomgVnQuWEOULDDFR|UxRTBwMd88US=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRyNECwOkc,OTd2MESwNFY9N2F-
Huh7 MUXBcpRqfmm{YXygZZN{[Xl? NGfWXYc2KGSjeYO= MU\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYh\2Wwb4T5dIUhTCC5aYToJJJmfmW{c3WgeJJidnOlcnnweIF{\SCOOEDJJI12fGG2aX;uJIlvKGi3bXHuJGh2cDdiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjC1JIRigXNuIFXDOVA:OC5yM988US=> NG\yTHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SzPFA1Pyd-MUe0N|gxPDd:L3G+
Huh7 NYTM[ZMySW62aY\pdoFtKGG|c3H5 NVX4clZUPSCmYYnz NEHwVGtCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSmWDZz3k[YZq[2mnboSgTGJXKGenbn;0fZBmKERid3n0bEBxemWlb4LlJGcyQDl4QTDteZRifGmxbjDhcoQhemW4ZYLz[UB1emGwc3PybZB1[XOnIFy4NGkhdXW2YYTpc44hcW5iaIXtZY4hUHWqNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGGodHXyJFUh\GG7czygSWM2OD1yLkCz{txO NFjsR5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SzPFA1Pyd-MUe0N|gxPDd:L3G+
Huh7 NUTaVFk4SW62aY\pdoFtKGG|c3H5 NUfDdGhwPSCmYYnz NVPXbGc4SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHflco91gXCnIFSgbY4hcHWvYX6gTJVpPyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEWg[IF6eyxiRVO1NF0xNjRzzszN MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR|OEC0O{c,OTd2M{iwOFc9N2F-
Huh7 Mle2RY51cX[rcnHsJIF{e2G7 M3L0VVUh\GG7cx?= M1r4dmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhD\UGpLXTl[olkcWWwdDDIRnYh\2Wwb4T5dIUhTCC5aYToJJBz\WOxcnWgS|E5QT[DIH31eIF1cW:wIHnuJIh2dWGwIFj1bFch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB3IHThfZMtKEWFNUC9NE41Ps7:TR?= M{LkeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEO4NFQ4Lz5zN{SzPFA1PzxxYU6=
HepG2(2.2.15) M3zhU2FvfGm4aYLhcEBie3OjeR?= NV\UZXZRSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnuJIF6fyC5aXzkJJR6eGViSHXwS|IpOi5{LkG1LUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKESQQTDy[ZBtcWOjdHnvckwhUUN3ME2wMlA2|ryP NYD4S|lERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PFg5OTdpPkG3OFg5QDF5PD;hQi=>
HepG2(2.2.15) NXW3PFZqTnWwY4Tpc44h[XO|YYm= M2PydmlvcGmkaYTpc44hd2ZiSFLWJJBzd22xdHXyJIlvKGi3bXHuJGhmeEd{KEKuNk4yPSliY3XscJMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuNFjPxE1? NWTYUXRXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PFg5OTdpPkG3OFg5QDF5PD;hQi=>
HepW10 MWXBcpRqfmm{YXygZZN{[Xl? MYDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW5iYXTybYFugWOrbj3y[ZNqe3SjboSge4lt\CC2eYDlJGhmeFdzMDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJGRPSSC{ZYDsbYNifGmxbjygTWM2OD1yLkJOwG0> NXHjN2ZiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PFg5OTdpPkG3OFg5QDF5PD;hQi=>
HBV-Met NHz2bWtCdnSrdnnyZYwh[XO|YYm= Mof5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwIH3veZNmKGG7dzD3bYxlKHS7cHWgTGJXNU2ndDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJGRPSSC{ZYDsbYNifGmxbjygTWM2OD1yLkNOwG0> NID6N5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S4PFgyPyd-MUe0PFg5OTd:L3G+
HepG2.2.15 NVW2XZRTTnWwY4Tpc44h[XO|YYm= MX24JIRigXN? NEnKRVlKdmirYnn0bY9vKG:oIHP5eI9xdGG|bXnjJGhDXiCGTlGgd5lvfGinc3nzJIlvKEincFeyMlIvOTViY3XscJMh[W[2ZYKgPEBl[Xm|LDDJR|UxRTBwM{lOwG0> M4\RO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEm5PFg6Lz5zN{S5PVg5QTxxYU6=
PBMC M3T1S2Z2dmO2aX;uJIF{e2G7 MW[zNFAhdWd? MWO3JIRigXN? MYHDcYF5KGmwIFjJWk1qdm[nY4Tl[EBpfW2jbjDhd5Nme3OnZDDhd{BN[W2rdoXkbY5mKG2xbn;wbI9{eGijdHWgcIV3\WxiaX6gVGJOSyCjdDCzNFAhdWdiUVSg[o9zKDdiZHH5d{Bu\WG|dYLl[EBx\XJiMUCnOkBk\WyuczDpckBxemW|ZX7j[UBw\iC8aXTvepVlcW6nLDDDcYF5RTBwMECwNFAxQM7:TR?= NEfI[Zk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[2OFMzQCd-MUe2OlQ{Ojh:L3G+
PBMC MWTGeY5kfGmxbjDhd5NigQ>? NY\sUZJiOzByIH3n NG\WZ3c4KGSjeYO= NVvxOo55S22jeDDpckBJUVZvaX7m[YN1\WRiaIXtZY4h[XO|ZYPz[YQh[XNiTHHtbZZ2\GmwZTDkbZBpd3OyaHH0[UBt\X[nbDDpckBRSk2FIHH0JFMxOCCvZzDRSEBnd3JiNzDkZZl{KG2nYYP1doVlKHCncjCxNEc3KGOnbHzzJIlvKHC{ZYPlcoNmKG:oIIrp[I93fWSrbnWsJGNu[Xh;MD6wNFAxODR2zszN MkDJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkSzNlgoRjF5Nk[0N|I5RC:jPh?=
PBMC NWfQfWcxTnWwY4Tpc44h[XO|YYm= NUGzO4oxOzByIH3n M{\CSlch\GG7cx?= M2\QVGNu[XhiaX6gTGlXNWmwZnXjeIVlKGi3bXHuJIF{e2W|c3XkJIF{KEyjbXn2eYRqdmVidILpdIhwe3CqYYTlJIxmfmWuIHnuJHBDVUNiYYSgN|AxKG2pIGHEJIZweiB5IHThfZMhdWWjc4Xy[YQheGW{IEGwK|Yh[2WubIOgbY4heHKnc3XuZ4Uhd2Ziennkc5Z2\GmwZTygR41igD1yLkCwNFAxPDkQvF2= MnrRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkSzNlgoRjF5Nk[0N|I5RC:jPh?=
MAGIC-5A MkDPRY51cX[rcnHsJIF{e2G7 MnfHOFAhcHK| MkXqRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\CC2eYDlJGhKXjFiTly0MVMheHKxZIXj[YQh\nKxbTDmeYxtKGynbnf0bEBxWjmmZXz0ZWFx[SCrbn\lZ5Rm\CCrbjDoeY1idiCPQVfJR{02SSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxi[ytiZn;jbUBmgHC{ZYPzbY9vKGGodHXyJFQxKGi{czygSWM2OD1yLki4{txO NGTlRVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m2O|kyOyd-MUe5Olc6OTN:L3G+
MAGIC-5A NWDJRXl3SW62aY\pdoFtKGG|c3H5 M{GxdFQxKGi{cx?= MmfwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\CC2eYDlJGhKXjJiUl;EJJBzd2S3Y3XkJIZzd21iZoXscEBt\W6pdHigdHJQTDliaX7m[YN1\WRiaX6gbJVu[W5iTVHHTWMuPUFiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBN[WNtIH\vZ4kh\XiycnXzd4lwdiCjZoTldkA1OCCqcoOsJGVEPTB;Mt88US=> M1Xyd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OU[3PVE{Lz5zN{m2O|kyOzxxYU6=
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MT2 MXHBcpRqfmm{YXygZZN{[Xl? M3TYV|Uh\GG7cx?= MXjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDCwMlA2KE2RSTD3bYxlKHS7cHWgTGlXOSCQTEStN{Bqdm[nY4Tl[EBqdiB{IHjyMZBz\XS{ZXH0[YQhcHWvYX6gUXQzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEWg[IF6eyCkeTDNWHMh[XO|YYmsJGVEPTB;Mz6yOFfPxE1? NWHQeGFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVY2OjFpPkG4N|E3PTJzPD;hQi=>
HepG2(2.2.15) NGDFUndCdnSrdnnyZYwh[XO|YYm= NWj3cWZNOjRiaILz NXywVG51SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnuJIh2dWGwIFjldGczMDJwMj6xOUkh[2WubIOgZZN{\XO|ZXSgZZMh\Xi2cnHj[YxtfWyjcjDIRnYhfmm{aX;uJGRPSSCuZY\lcEBi\nSncjCyOEBpenNuIFXDOVA:OC5yNElOwG0> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5Mk[5OEc,OTlyN{K2PVQ9N2F-
HepG2(2.2.15) MnLNRY51cX[rcnHsJIF{e2G7 NULPVnRCOjRiaILz Ml:xRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwIHj1cYFvKEincFeyLFIvOi5zNTmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVxdGmlYYTpc44hcW62ZYLt[YRq[XSnczDh[pRmeiB{NDDodpMtKEWFNUC9NE4yPc7:TR?= M1PNfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7 NXXSVFRLSW62aY\pdoFtKGG|c3H5 NG\wb2I1KGSjeYO= NIXKcpJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBt[W2rdoXkbY5mNXKnc3nzeIFvfCC5aXzkJJR6eGViSFLWJIlvKGi3bXHuJGh2cDdiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JIlvfHKjY3XscJVt[XJiSFLWJGRPSSC{ZYDsbYNifGmxbjDhd5NigSxiRVO1NF0xNjMQvF2= M2G4WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7 NITOPGpCdnSrdnnyZYwh[XO|YYm= M{GwT|Qh\GG7cx?= Mne2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgcIFucX[3ZHnu[U1z\XOrc4ThcpQhUEKYIILleoVze2VidILhcpNkemmydHHz[UAzOz[WIH31eIFvfCCrbjDoeY1idiCKdXi3JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO|YYmsJGVEPTB;MD6z{txO MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5Mk[5OEc,OTlyN{K2PVQ9N2F-
Huh7 MnXVRY51cX[rcnHsJIF{e2G7 MYK0JIRigXN? MXHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IVnd3[rcj3y[ZNqe3SjboSge4lt\CC2eYDlJGhDXiCrbjDoeY1idiCKdXi3JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO|YYmsJGVEPTB;MT6z{txO NHLvR5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 NV6xeHBISW62aY\pdoFtKGG|c3H5 NWTKPHZWPCCmYYnz MoXXRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRm\m:4aYKtdoV{cXO2YX70JGhDXiC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUVIxPFZibYX0ZY51KGmwIHj1cYFvKEi3aEegZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KGmwdILhZ4VtdHWuYYKgTGJXKESQQTDy[ZBtcWOjdHnvckBie3OjeTygSWM2OD1zLkZOwG0> M1z2ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7 MWDBcpRqfmm{YXygZZN{[Xl? NIG1flM1KGSjeYO= MlfnRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRm\m:4aYKtdoV{cXO2YX70JGhDXiC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUFE5OE1ibYX0ZY51KGmwIHj1cYFvKEi3aEegZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KGmwdILhZ4VtdHWuYYKgTGJXKESQQTDy[ZBtcWOjdHnvckBie3OjeTygSWM2OD1zLkdOwG0> NFzVO3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 NUTPWmFbSW62aY\pdoFtKGG|c3H5 MXK0JIRigXN? M4i3XWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl\W[xdnnyMZJme2m|dHHueEBJSlZicnX2[ZJ{\SC2cnHud4NzcXC2YYPlJGxON3KndnXyd4UhfHKjboPjdolxfGG|ZTDNWkBld3WkbHWgcZV1[W62IHnuJIh2dWGwIFj1bFch[2WubIOgZYZ1\XJiNDDkZZl{KGK7IHnueJJi[2WubIXsZZIhUEKYIFTORUBz\XCuaXPheIlwdiCjc4PhfUwhTUN3ME2xMlbPxE1? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5Mk[5OEc,OTlyN{K2PVQ9N2F-
Huh7 MVTBcpRqfmm{YXygZZN{[Xl? M3vxS|Qh\GG7cx?= M4DRVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl\W[xdnnyMZJme2m|dHHueEBJSlZicnX2[ZJ{\SC2cnHud4NzcXC2YYPlJG0zODSLIH31eIFvfCCrbjDoeY1idiCKdXi3JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO|YYmsJGVEPTB;MT64{txO MonEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
Huh7 M3H2UmFvfGm4aYLhcEBie3OjeR?= NEjFfJk1KGSjeYO= NYPyWnFrSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSnZn;2bZIuemW|aYP0ZY51KEiEVjDy[ZZmenOnIITyZY5{[3KrcIThd4UhOjN4VDDteZRidnRiaX6gbJVu[W5iSIXoO{Bk\WyuczDh[pRmeiB2IHThfZMh[nliaX70doFk\WyudXzhdkBJSlZiRF7BJJJmeGyrY3H0bY9vKGG|c3H5MEBGSzVyPUeuO:69VQ>? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5Mk[5OEc,OTlyN{K2PVQ9N2F-
Huh7 NHPVTpBCdnSrdnnyZYwh[XO|YYm= M1PkPFQh\GG7cx?= M2jXV2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIxidWm4dXTpcoUuemW|aYP0ZY51KEiEVjDy[ZZmenOnIITyZY5{[3KrcIThd4UhVDF6MF2gcZV1[W62IHnuJIh2dWGwIFj1bFch[2WubIOgZYZ1\XJiNDDkZZl{KGK7IHnueJJi[2WubIXsZZIhUEKYIFTORUBz\XCuaXPheIlwdiCjc4PhfUwhTUN3ME2xNO69VQ>? MlvaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
HuH7 Mor5RY51cX[rcnHsJIF{e2G7 MUKyOEBpenN? NWGwem9SSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiEVjDpcoZm[3SnZDDpckBpfW2jbjDIeWg4KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwII\pdoFtKHS{YX7zbYVvfCC2cnHud4Zm[3Srb36gZYZ1\XJiMkSgbJJ{NCCHQ{WwQVAvOs7:TR?= NV\yTlJiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzPVg3PDhpPkG5N|k5PjR6PD;hQi=>
HuH7 MmXPRY51cX[rcnHsJIF{e2G7 NXnMXW1MOjRiaILz MV;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcGG{Yn;ybY5oKFKQQTDwc4x6dWW{YYPlJG4zOz[WIH31eIFvfCCpZX7lJIlv\mWldHXkJIlvKGi3bXHuJGh2UDdiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6geolz[WxidILhcpNq\W62IITyZY5{\mWldHnvckBi\nSncjCyOEBpenNuIFXDOVA:OC5|zszN M3niO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m4OlQ5Lz5zOUO5PFY1QDxxYU6=
HuH7 M17seGFvfGm4aYLhcEBie3OjeR?= MlPoNlQhcHK| NGn1R5hCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaHHyZo9zcW6pIGLORUBxd2y7bXXyZZNmKE5{M{\UJI12fGGwdDDn[Y5mKGmwZnXjeIVlKGmwIHj1cYFvKEi3SEegZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hfmm{YXygeJJidnOrZX70JJRz[W6|ZnXjeIlwdiCjZoTldkAzPCCqcoOsJGVEQTB;MT61{txO MmTUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUi2OFgoRjF7M{m4OlQ5RC:jPh?=
HuH7 MXvBcpRqfmm{YXygZZN{[Xl? MYKyOEBpenN? M2W5U2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSIXIO{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiC4aYLhcEB1emGwc3nlcpQhfHKjboPm[YN1cW:wIHHmeIVzKDJ2IHjyd{whTUN7ME2z{txO M2nE[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m4OlQ5Lz5zOUO5PFY1QDxxYU6=
HuH7 NF;VXmRCdnSrdnnyZYwh[XO|YYm= NV\ONoV7OjRiaILz MYLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcGG{Yn;ybY5oKFKQQTDwc4x6dWW{YYPlJGwyQDCPIH31eIFvfCCpZX7lJIlv\mWldHXkJIlvKGi3bXHuJGh2UDdiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6geolz[WxidILhcpNq\W62IITyZY5{\mWldHnvckBi\nSncjCyOEBpenNuIFXDOVA:OTcQvF2= NV;DS3ZGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzPVg3PDhpPkG5N|k5PjR6PD;hQi=>
HuH7 Ml7nRY51cX[rcnHsJIF{e2G7 MmPyNlQhcHK| MWrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcGG{Yn;ybY5oKFKQQTDwc4x6dWW{YYPlJGwyQDCPIH31eIFvfCCpZX7lJIlv\mWldHXkJIlvKGi3bXHuJGh2UDdiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6geolz[WxidILhcpNq\W62IITyZY5{\mWldHnvckBi\nSncjCyOEBpenNuIFXDPVA:PDIQvF2= NXTUcXJpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzPVg3PDhpPkG5N|k5PjR6PD;hQi=>
MT2 M3P2SmFvfGm4aYLhcEBie3OjeR?= MV;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKGmwZnXjeIVlKGmwIHj1cYFvKE2WMjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vNCCLQ{WwQVAvPs7:TR?= MmewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3OU[4PFUoRjF7NUm2PFg2RC:jPh?=
HeLa P4/R5 MmfSRY51cX[rcnHsJIF{e2G7 M{XyT2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiaX7m[YN1\WRiaX6gbJVu[W5iSHXMZUBRPC:UNTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vNCCLQ{WwQVAvPzkQvF2= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV7Nki4OUc,OTl3OU[4PFU9N2F-
TZM-bl M33RSGFvfGm4aYLhcEBie3OjeR?= NYPmR3BtPzJiaILz MkPpRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCyTly0MVMhcGG{Yn;ybY5oKFKndnXyd4UhfHKjboPjdolxfGG|ZTDQNVE6WyCvdYThcpQh\2WwZTDpcoZm[3SnZDDpckBVYk1vYnygZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGy3Y3nm[ZJie2ViYYPzZZktKEWFNUC9NE41P87:TR?= MmPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5MESxN|EoRjF7N{C0NVMyRC:jPh?=
TZM-bl NHXVRWNCdnSrdnnyZYwh[XO|YYm= MXvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlNXS7cHWgTGlXOSCyTly0MVMhcW6oZXP0[YQhcW5iVGrNMYJtKGOnbHzzJIJ6KGy3Y3nm[ZJie2ViYYPzZZktKEWFNUC9NE43Pc7:TR?= MlX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5MESxN|EoRjF7N{C0NVMyRC:jPh?=
TZM-bl NUfWdll7SW62aY\pdoFtKGG|c3H5 MVO3NkBpenN? NX7lNnh5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDwUmw1NTNiaHHyZo9zcW6pIGLleoVze2VidILhcpNkemmydHHz[UBVOTZ3QTDteZRidnRiZ3Xu[UBqdm[nY4Tl[EBqdiCWWl2tZowh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHz1Z4ln\XKjc3WgZZN{[XluIFXDOVA:OS5yON88US=> NUn5PHRXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NFQyOzFpPkG5O|A1OTNzPD;hQi=>
TZM-bl NVjaRXg2SW62aY\pdoFtKGG|c3H5 NFT6U4U4OiCqcoO= MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKHCQTEStN{Bp[XKkb4LpcochWmW4ZYLz[UB1emGwc3PybZB1[XOnIGCxNVlUN1RzNkXBJI12fGGwdDDn[Y5mKGmwZnXjeIVlKGmwIGTaUU1jdCClZXzsd{Bi\nSncjC3NkBpenNiYomgcJVkcW[ncnHz[UBie3OjeTygSWM2OD1{LkJOwG0> NFjmS209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUewOFE{OSd-MUm3NFQyOzF:L3G+
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HepG2(2.2.15) MV;BcpRqfmm{YXygZZN{[Xl? MlvOOkBl[Xm| NUf3PWtoSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHH5e|EhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygdoVxdGmlYYTpc44h[nlibXXhd5VzcW6pIHnueJJi[2WubIXsZZIhfmm{YXygSG5CKGOxcImgcpVu[mW{IHHmeIVzKDZiZHH5d{BjgSC{ZXHsMZRqdWVicWDDVkBu\XSqb3SsJGVEPTB:MD6wNe69VQ>? NIrPTpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e0PFU6OCd-Mke3OFg2QTB:L3G+
HepG2(2.2.15) MmK1RY51cX[rcnHsJIF{e2G7 MXO2JIRigXN? MXrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYh[Xm5MTDpcoZm[3SnZDDpckBpfW2jbjDI[ZBIOih{LkKuNVUqKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCC{ZYDsbYNifGmxbjDifUBu\WG|dYLpcoch\Xi2cnHj[YxtfWyjcjD2bZJidCCGTlGgZ49xgSCwdX3i[ZIh[W[2ZYKgOkBl[Xm|IHL5JJJm[WxvdHnt[UByWEOUIH3leIhw\CxiRVO1NF0xNjBzzszN NIKyfZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e0PFU6OCd-Mke3OFg2QTB:L3G+
MT4 NV;Y[3pPSW62aY\pdoFtKGG|c3H5 NEfidlY2KGSjeYO= NYDpWJNPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTCzRkBqdm[nY4Tl[EBqdiCqdX3hckBOXDRiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2II\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOUBl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2yMlIz|ryP NFvuU4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e0PFU6OCd-Mke3OFg2QTB:L3G+
MT4 NEHoepBCdnSrdnnyZYwh[XO|YYm= M4r6XVUh\GG7cx?= MUjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYzKFKRRDDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgZYZ1\XJiNTDkZZl{KGK7IF3UWEBie3OjeTygSWM2OD16Lkix{txO NH\zb3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e0PFU6OCd-Mke3OFg2QTB:L3G+
Huh7 NX\MRYEySW62aY\pdoFtKGG|c3H5 M{TWO2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIxidWm4dXTpcoUuemW|aYP0ZY51KHerbHSgeJlx\SCqZYDheIl1cXNiQjD2bZJ2eyCrbn\lZ5Rm\CCrbjDoeY1idiCKdXi3JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC|ZXPy[ZRm\CCGTlGgcIV3\Wy|IH3lZZN2emWmIH;uJIRigSB5IHL5JJJm[WxvdHnt[UBRS1JiYX7hcJl{cXNuIFXDOVA:OC5yNUZOwG0> NIDEbGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4NlA3QCd-MkiwPFIxPjh:L3G+
HepG2.215 NX7hOpRvSW62aY\pdoFtKGG|c3H5 MnXPRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbIVx[XSrdHnzJGIhfmm{dYOgbY5n\WO2ZXSgbY4hcHWvYX6gTIVxTzJwMkG1JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYLhcEBFVkFicnXwcIlk[XSrb36gcYVie3W{ZXSgc44h\GG7IEegZpkhemWjbDD0bY1mKFCFUjDhcoFtgXOrczygSWM2OD1yLkJOwG0> NIPCOXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4NlA3QCd-MkiwPFIxPjh:L3G+
Huh7 NU\5SnplSW62aY\pdoFtKGG|c3H5 MlXLRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgcIFucX[3ZHnu[U1z\XOrc4ThcpQhf2muZDD0fZBmKGincHH0bZRqeyCEII\pdpV{KGmwZnXjeIVlKGmwIHj1cYFvKEi3aEegZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGmwdILhZ4VtdHWuYYKgSG5CKGyndnXsd{Bu\WG|dYLl[EBwdiCmYYmgO{BjgSC{ZXHsMZRqdWViUFPSJIFv[Wy7c3nzMEBGSzVyPUCuNlM4|ryP NUnGUolKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFIxPjhpPkK4NFgzODZ6PD;hQi=>
HepG2.215 NVXQ[IpQSW62aY\pdoFtKGG|c3H5 NVfaUVNqSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcGWyYYTpeIl{KEJidnnyeZMhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KuNlE2KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCCGTlGgdoVxdGmlYYTpc44hdWWjc4Xy[YQhd25iZHH5JFch[nlicnXhcEB1cW2nIGDDVkBidmGueYPpd{whTUN7ME2y{txO NF7Jd4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4NlA3QCd-MkiwPFIxPjh:L3G+
HepAD38 MVrBcpRqfmm{YXygZZN{[Xl? M{f5bFUh\GG7cx?= MnrTRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN|gh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDEUmEhemWybHnjZZRqd25iYX\0[ZIhPSCmYYnzJIJ6KFKWLWDDVkBu\XSqb3SsJGVEPTB;MD6wOO69VQ>? NUTGVnVHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPVQyPzlpPkK4NFk1OTd7PD;hQi=>
P4R5 MAGI MVvGeY5kfGmxbjDhd5NigQ>? MXyyJIhzew>? NXG3SZRLUW6qaXLpeIlwdiCxZjDITXYyKEKjTDDkbY52[2ynb4Pp[IUhemW4ZYLz[UB1emGwc3PybZB1[XOnIHnu[oVkfGWmIHnuJIh2dWGwIGC0VlUhVUGJSTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygbY5n\WO2aX;uJIFnfGW{IEKgbJJ{KGK7IFfhcIFkfG9vU4ThdkBj\XSjLXfhcIFkfG:|aXThd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0yOS5|zszN NGPlNWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO1NVU5QCd-MkizOVE2QDh:L3G+
P4R5 MAGI M3zkR2Z2dmO2aX;uJIF{e2G7 NI\4PZIzKGi{cx?= M3;hWGlvcGmkaYTpc44hd2ZiSFnWNUA{SiCmaX71Z4xmd3OrZHWgdoV3\XK|ZTD0doFve2O{aYD0ZZNmKGmwZnXjeIVlKGmwIHj1cYFvKFB2UkWgUWFIUSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxiaX7m[YN1cW:wIHHmeIVzKDJiaILzJIJ6KEejbHHjeI8uW3SjcjDi[ZRiNWejbHHjeI9{cWSjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2zNk44|ryP MoLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|NUG1PFgoRjJ6M{WxOVg5RC:jPh?=
HepG2.2.15 MUDBcpRqfmm{YXygZZN{[Xl? NVf3fWlsQCCmYYnz MWDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZBifGm2aYOgRkB3cXK3czDpcoZm[3SnZDDpckBpfW2jbjDI[ZBIOi5{LkG1JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhTE6DIILldIxq[2G2aX;uJIFnfGW{IEig[IF6eyCkeTDy[YFtKHSrbXWg[ox2d3Knc3PlcpQhWEOUIH3leIhw\CxiSVO1NF0xNjYQvF2= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR7NEK1Nkc,Ojh2OUSyOVI9N2F-
MT4 NYHpNoZqSW62aY\pdoFtKGG|c3H5 MYG1JIRigXN? NYnuVYdWSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiLVkGgN2IhcW6oZXP0[YQhcW5iaIXtZY4hVVR2IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB3IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTJwNUVOwG0> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ3OUK0Okc,Ojh4NUmyOFY9N2F-
HepG2(2.2.15) NWHrRXNoSW62aY\pdoFtKGG|c3H5 Mlm2OkBl[Xm| M2TUTmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCjeYexJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{KEKuNk4yPSliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuIILldIxq[2G2aX;uJIJ6KG2nYYP1dolv\yCrboTyZYNmdGy3bHHyJJZqemGuIFTORUBkd3C7IH71cYJmeiCjZoTldkA3KGSjeYOgZplzKGK7IILlZYwufGmvZTDxVGNTKGG|c3H5MEBGSzVyPUCuNFA5QDgQvF2= MmrWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEKwOlcoRjJ6NkiyNFY4RC:jPh?=
HepG2(2.2.15) NHXEeoxCdnSrdnnyZYwh[XO|YYm= NFzKVFY3KGSjeYO= MYfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYh[Xm5MTDpcoZm[3SnZDDpckBpfW2jbjDI[ZBIOih{LkKuNVUqKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCC{ZYDsbYNifGmxbjDifUBu\WG|dYLpcoch\Xi2cnHj[YxtfWyjcjD2bZJidCCGTlGgZ49xgSCwdX3i[ZIh[W[2ZYKgOkBl[Xm|IHL5JJJm[WxvdHnt[UByWEOUIH3leIhw\CxiRVO1NF0xNjB{zszN NYjUSHYzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PFIxPjdpPkK4OlgzODZ5PD;hQi=>
HepAD38 M3HFN2FvfGm4aYLhcEBie3OjeR?= NF3NeG1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwRWQ{QCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gbY51emGlZXzseYxieiC4aYLhcEBFVkFibHX2[Ywh[nliUmStVGNTKG2ndHjv[EwhTUN3MEywMlAy|ryP M1LP[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Nki4NlgxLz5{OE[4PFI5ODxxYU6=
HepAD38 NXzDSnd1SW62aY\pdoFtKGG|c3H5 Mn7SRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN|gh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdoFtKHKncHzpZ4F1cW:wIHL5JHJVNVCFUjDt[ZRpd2RuIFXDOVA:OC5yNN88US=> NWT0WGgzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PFgzQDBpPkK4Olg5OjhyPD;hQi=>
HepAD38 NHPafIVCdnSrdnnyZYwh[XO|YYm= M{nRdGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDBSFM5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDlfJRz[WOnbHz1cIFzKH[rcnHsJGRPSSCuZY\lcEBjgSCUVD3QR3IhdWW2aH;kMEBGSzVyPUCuNFTPxE1? MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6OEK4NEc,Ojh4OEiyPFA9N2F-
HepAD38 M4XOemFvfGm4aYLhcEBie3OjeR?= NFSxeHpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwRWQ{QCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxicnXwcIlk[XSrb36gZpkhWlRvUFPSJI1mfGixZDygSWM6OD1yLkROwG0> NV\WemlpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PFgzQDBpPkK4Olg5OjhyPD;hQi=>
HepAD38 NUjCOZpESW62aY\pdoFtKGG|c3H5 NEH6Vm5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwRWQ{QCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6g[Zh1emGlZXzseYxieiC4aYLhcEBFVkFibHX2[Ywh[nliUmStVGNTKG2ndHjv[EwhTUN7ME2wMlPPxE1? Mn3kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEiyPFAoRjJ6Nki4NlgxRC:jPh?=
HepAD38 M1PVUGFvfGm4aYLhcEBie3OjeR?= MWPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW6oZXP0[YQhcW5iaIXtZY4hUGWyQVSzPEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iaX70doFk\WyudXzhdkB3cXKjbDDEUmEhdGW4ZXygZpkhWlRvUFPSJI1mfGixZDygSWM6OD1yLkhOwG0> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6OEK4NEc,Ojh4OEiyPFA9N2F-
SupT1 NX2yXWZbSW62aY\pdoFtKGG|c3H5 M{TiTVQ5KGi{cx?= MV3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDWV3YuTyCyc3X1[I91gXCnZDDITXYyKGmwZnXjeIVlKGmwIHj1cYFvKFO3cGSxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MD6x{txO M1i4elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEG2NVMyLz5{OUCxOlE{OTxxYU6=
HepG2(2.2.15) NEK3NmdCdnSrdnnyZYwh[XO|YYm= MonjOkBl[Xm| MkX5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFeyLFIvOi5zNTmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBFVkFicnXwcIlk[XSrb36gZYZ1\XJiNjDkZZl{KGK7IGLUMXBEWiCvZYToc4QtKEmFNUC8NE4y|ryP MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ6OEm0N{c,Ojl{OEi5OFM9N2F-
A549 M2nIVGFvfGm4aYLhcEBie3OjeR?= NGLndnRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzII\pdolwdnNiZHXybZZm\CCocn;tJGhKXi:YU1etS{BweiCKSW[vTGEhfmm{aX;ud{Bqdm[nY4Tl[EAzQTOWIHPlcIx{KHW|aX7nJIh2dWGwIFG1OFkh[2WubIOgZZMhfGG{Z3X0JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25idYPpcoch[2:vcH;1coQheHKnLX3pfIVlKH[rcnnvcpMh\m:ubH;3[YQh[nliaX7jeYJifGmxbjD3bZRpKHSjcnfleEBk\WxuIFnDOVA:OC53Md88US=> MnfXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4OUm5NlQoRjJ7Nkm5PVI1RC:jPh?=
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Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 46 mg/mL
(200.64 mM)
Water 46 mg/mL
(200.64 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 229.26
Formula

C8H11N3O3S

CAS No. 134678-17-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C(OC(S1)CO)N2C=CC(=NC2=O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04133012 Recruiting Other: Samplings HIV-1 Infection ANRS Emerging Infectious Diseases|ViiV Healthcare February 10 2020 Not Applicable
NCT03869944 Recruiting Drug: Lamivudine Oral Solution HIV-1 ANRS Emerging Infectious Diseases|Institut National de la Santé Et de la Recherche Médicale France|Centre Muraz December 4 2019 Phase 2
NCT04034862 Not yet recruiting Drug: Treatment simplification (dolutegravir lamivudine) HIV Infections University of Liege October 1 2019 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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