Lamivudine

Catalog No.S1706 Synonyms: GR109714X

Lamivudine  Chemical Structure

Molecular Weight(MW): 229.26

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
USD 117 In stock
USD 187 In stock
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1 Customer Review

  • The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.

    Oncotarget, 2017, 8(15):24694-24705. Lamivudine purchased from Selleck.

Purity & Quality Control

Choose Selective Reverse Transcriptase Inhibitors

Biological Activity

Description Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.
Targets
Reverse transcriptase [1]
In vitro

Lamivudine’s anti- HBV activity, like its anti-HIV activity, has been shown to depend on the ability of LMV-TP to serve as both substrate and inhibitor of the DNA- and RNA-dependent polymerase activities of the HBV P gene product. Lamivudine owes its activity to the remarkably broad substrate specificity of deoxycytidine kinase and the unusual substrate preference of the HBV polymerases for dNTPs with the unnatural L-conformation, whereas the anti-HBV activity of PCV appears to depend on several factors including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity) by key cellular enzymes, the long intracellular half-life of PCV-TP and the ability of PCV-TP to inhibit the HBV RT priming reaction as well as RT and DNA polymerase activity. [1] Lamivudine and Penciclovir inhibits duck hepatitis B virus (DHBV) replication to a comparable extent when used alone, and in combination, the two nucleoside analogs acts synergistically over a wide range of clinically relevant concentrations. Lamivudine combined with Penciclovir is more effective in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV than either drug alone. [2] Lamivudine inhibits p24 antigen production by HIV-I in PBMC, with ED50s ranging from 0.07 μM to 0.2 μM. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
2.2.15 cells M{C4O2Z2dmO2aX;uJIF{e2G7 MW\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZBifGm2aYOgRkB3cXK3czCoTGJXMSCrbjCyMlIvOTViY3XscJMtKEWFNUC9NE4xODhizszN MY[xNVA2Ojd7NR?=
PBMC cells NIHCVWpHfW6ldHnvckBie3OjeR?= NHjtUHdG\m[nY4TpeoUh[2:wY3XueJJifGmxbjD0c{BqdmirYnn0JGhKXi1zIFzBTUBkgXSxcHH0bIlkcXS7IHnuJHBDVUNiY3XscJMhf2G|IHTleIVzdWmwZXSgbY4hfmm2cn:sJGVEPTB;MD6wNVE3KM7:TR?= NHHUNZoyPDl5MUi5PC=>
human MT2 cells NFHSbGJHfW6ldHnvckBie3OjeR?= MnXiOUBl[Xm| NX3YSopnSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yMEWgUW9KKHerbHSgeJlx\SCKSW[xJG5NPC1|IHnu[oVkfGWmIHnuJIh2dWGwIF3UNkBk\WyuczDt[YF{fXKnZDDh[pRmeiB3IHThfZMh[nliUmSgV3BCNCCHQ{WwQVAvODRizszN NYm1[pVYOTh|MU[1NlE>
human H9 cells MXfGeY5kfGmxbjDhd5NigQ>? Mn[zRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSB|QjDpckBpfW2jbjDIPUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[nliZn;ycYF7[W5vYnHz[YQh[2:wdnXueIlwdmGuIHPvcI9zcW2ndILpZ{B1\WOqbnnxeYUtKEWFNUC9NE4xPiEQvF2= M33WN|EyPDNyMEG5
human HuH7 cells NH7BUWNEgXSxdH;4bYNqfHliYYPzZZk> NEjZOXY1KGSjeYO= NHLwV2NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfUh5IHPlcIx{KGGodHXyJFQh\GG7czDifUBv\XW2cnHsJJJm\CCmeXWgeZB1[WunIHHzd4F6NCCFQ{WwQVAvOSEQvF2= MV[yNVM{OzV|NR?=
MT-4 cell NWXKdZVDTnWwY4Tpc44h[XO|YYm= NFLLZXdEd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgd5lvfGmlYTDmc5Ju[XSrb36gZpkhPTBnIHnuJGhKXi1zIHnu[oVkfGWmIF3UMVQh[2WubIOsJGlEPTB;MD6xJO69VQ>? NWTlOmFwQDB|NUSyPS=>
HepG2.2.15 cells M2rGRmZ2dmO2aX;uJIF{e2G7 MV\F[oZm[3SrdnWgZ49v[2WwdILheIlwdiC2bzDpcohq[mm2IHjldIF1cXSrczDCJJZqenW|IHP5eI9x[XSqaXPpeJkhcW5iSHXwS|IvOi5zNTDj[YxteyC5YYOg[IV1\XKvaX7l[EBqdiC4aYTyc{whTUN3ME2wMlIh|ryP MoKwNVQ6PzF6OUi=
CEM-SS cells M4PCZWZ2dmO2aX;uJIF{e2G7 NX3wS2kySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYLUGgd5VjfHmyZTCzRkBqdm[nY4Tl[EBqdiCFRV2tV3Mh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB4IHThfZMh[nliWGTUJIF{e2G7LDDFR|UxRTBwMjFOwG0> MkTlNlI5PThyOUe=
human HeLa P4/R5 cells MXzGeY5kfGmxbjDhd5NigQ>? MoL0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCrbn\lZ5Rm\CCrbjDoeY1idiCKZVzhJHA1N1J3IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44tKEmFNUC9NE44QCEQvF2= M3HPNFE6PTl4OEi1
HEK293 cells Mn\rSpVv[3Srb36gZZN{[Xl? NGXyR2Y4OiCq M1[2O2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFic4XieJlx\SCGIHnzc4xifGViODDpcoZm[3SnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{Bz\XCuaXPheIlwdiCjZoTldkA4OiCqcoOsJGVEPTB;Mz6yOUDPxE1? MYiyNFMxQDN5Nx?=
MDCK2 cells NV3m[Y9rTnWwY4Tpc44h[XO|YYm= MonVNVAh|ryP NX;3dlkxUW6qaXLpeIlwdiCxZjDoeY1idiCPUmCzJIV5eHKnc4Pl[EBqdiCPRFPLNkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJGNOTiCobIXvdoV{[2WwY3WgZZQhOTBidV2gZpkhS02IRFGgZZN{[Xl? NVnoTpBZOTdzN{KzNVE>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 46 mg/mL (200.64 mM)
Water 46 mg/mL (200.64 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 229.26
Formula

C8H11N3O3S

CAS No. 134678-17-4
Storage powder
in solvent
Synonyms GR109714X

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Molecular Weight Calculator

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03067285 Recruiting HIV Infections Fundacion SEIMC-GESIDA September 8 2017 Phase 4
NCT02582684 Completed HIV-1 Infection AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) December 8 2015 Phase 2
NCT02652260 Active not recruiting HIV-1 Infection|CNS Toxicity Merck Sharp & Dohme Corp. March 4 2016 Phase 2
NCT02509195 Completed HIV St Stephens Aids Trust|ViiV Healthcare August 4 2015 Phase 4
NCT03144804 Recruiting Colorectal Cancer Metastatic Massachusetts General Hospital October 31 2017 Phase 2
NCT03311945 Recruiting HIV Infections|HIV-1-infection|HIV Seropositivity David Garcia Cinca|Fundacion Clinic per a la Recerca Biomédica|Hospital Clinic of Barcelona May 3 2018 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID