Lamivudine (BCH-189)

For research use only.

Catalog No.S1706 Synonyms: GR109714X

9 publications

Lamivudine (BCH-189) Chemical Structure

CAS No. 134678-17-4

Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

Selleck's Lamivudine (BCH-189) has been cited by 9 publications

1 Customer Review

  • The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.

    Oncotarget, 2017, 8(15):24694-24705. Lamivudine (BCH-189) purchased from Selleck.

Purity & Quality Control

Choose Selective Reverse Transcriptase Inhibitors

Biological Activity

Description Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.
Targets
Reverse transcriptase [1]
In vitro

Lamivudine’s anti- HBV activity, like its anti-HIV activity, has been shown to depend on the ability of LMV-TP to serve as both substrate and inhibitor of the DNA- and RNA-dependent polymerase activities of the HBV P gene product. Lamivudine owes its activity to the remarkably broad substrate specificity of deoxycytidine kinase and the unusual substrate preference of the HBV polymerases for dNTPs with the unnatural L-conformation, whereas the anti-HBV activity of PCV appears to depend on several factors including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity) by key cellular enzymes, the long intracellular half-life of PCV-TP and the ability of PCV-TP to inhibit the HBV RT priming reaction as well as RT and DNA polymerase activity. [1] Lamivudine and Penciclovir inhibits duck hepatitis B virus (DHBV) replication to a comparable extent when used alone, and in combination, the two nucleoside analogs acts synergistically over a wide range of clinically relevant concentrations. Lamivudine combined with Penciclovir is more effective in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV than either drug alone. [2] Lamivudine inhibits p24 antigen production by HIV-I in PBMC, with ED50s ranging from 0.07 μM to 0.2 μM. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MT-4 NVfETmxKTnWwY4Tpc44h[XO|YYm= NHnFWpNEd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgd5lvfGmlYTDmc5Ju[XSrb36gZpkhPTBnIHnuJGhKXi1zIHnu[oVkfGWmIF3UMVQh[2WubIOsJGlEPTB;MD6x{txO NFz5W4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96MEO1OFI6Lz56MEO1OFI6RC:jPh?=
PBMC NVfVfoxVTnWwY4Tpc44h[XO|YYm= M4P0TmNwdmOnboTyZZRqd25icnXxeYlz\WRiZn;yJIFvfGm4aYLhcEBi[3Srdnn0fUBqdiCSQl3DJEhpfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJINmdGy|KTDpcoZm[3SnZDD3bZRpKEiLVj2xJJN1emGrbjDMRXYtKEWFNUC9NE4xODF6zszN M3fpXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh2MUC5O|UoRjh2MUC5O|U9N2F-
PBMC MYHGeY5kfGmxbjDhd5NigQ>? NV7TZYV5S2:wY3XueJJifGmxbjDy[ZF2cXKnZDDmc5Ih[W62aY\pdoFtKGGldHn2bZR6KGmwIGDCUWMhMGi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIh[2WubIOpJIlv\mWldHXkJJdqfGhiSFnWMVEhe3S{YXnuJGxCXixiRVO1NF0xNjJzzszN MlTUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDRzMEm3OUc,QDRzMEm3OVww[T5?
PBMC NX\tT3JDSW62aT3ITXYuOSCjc4PhfS=> MX;BcpRqNUiLVj2xJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjCoVGJOMSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjJWk0yKHO2cnHpckBNSVZuIFXDOVA:OC5yMEG4{txO NGPSUlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NEKzOVkyLz56NEKzOVkyRC:jPh?=
PBMC M2jMZWFvfGlvSFnWMVEh[XO|YYm= MUHBcpRqNUiLVj2xJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjCoVGJOMSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjJWk0yKHO2cnHpckBNSVZuIFXDOVA:OC5yNt88US=> NX\Rd|BRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOESyN|U6OSd-OESyN|U6OTxxYU6=
PBMC MmntRY51cS2KSW[tNUBie3OjeR?= MXjBcpRqNUiLVj2xJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjCoVGJOMSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjJWk0yKHO2cnHpckBNSVZuIFXDOVA:OC5{Md88US=> NGP4WVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NEKzOVkyLz56NEKzOVkyRC:jPh?=
PBMC MmjRRY51cS2KSW[tNUBie3OjeR?= NIr6dpdCdnSrLVjJWk0yKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkApWEKPKTDj[YxteyCrbn\lZ5Rm\CC5aYToJGhKXi1zIIP0doFqdiCOQW[sJGVEPTB;MUCuNe69VQ>? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85PDJ|NUmxK|45PDJ|NUmxQE9iRg>?
2.2.15 M4Loc2Z2dmO2aX;uJIF{e2G7 MmDlTY4hfmm2cn:g[YZn\WO2aY\lJINwdmOnboTyZZRqd25iYXfhbY5{fCCqZYDheIl1cXNiQjD2bZJ2eyC5YYOg[IV1\XKvaX7l[EBqdiB{LkKuNVUh[2WubIOsJGVEPTB;MD6wNFjPxE1? M4LxUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl|MEG2OVkoRjl|MEG2OVk9N2F-
PBMC NGjqeXlCdnSrLVjJWk0yKGG|c3H5 NW\keYVyUW5idnn0do8h[W62aT3ITXYh[WO2aY\peJkhcW5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjDj[YxteyxiRVO1NF0xNjB5zszN NFPMdG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97M{CxOlU6Lz57M{CxOlU6RC:jPh?=
2.2.15 M{fJWGFvfGm4aYLhcEBie3OjeR?= MlG3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVx[XSrdHnzJGIhfmm{dYOgLGhDXiliaX6gNk4zNjF3IHPlcIx{NCCHQ{WwQVAvODB6zszN M2PUVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEWyO|k2Lz5zMUC1Nlc6PTxxYU6=
PBMC M3\IT2FvfGm4aYLhcEBie3OjeR?= M4nIc2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGludXWwb3Tl[olkcWWwY4mgeolzfXNidInw[U0yKCiKSW[tNUkhcW5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjDj[YxteyxiRVO1NF0xNjB5zszN MmiwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyNUK3PVUoRjFzMEWyO|k2RC:jPh?=
H9 M2\qR2FvfGm4aYLhcEBie3OjeR?= MXHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKDOEIHnuJIh2dWGwIFi5JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBjgSCob4LtZZpidi2kYYPl[EBkd264ZX70bY9v[WxiY3;sc5JqdWW2cnnjJJRm[2iwaYH1[UwhTUN3ME2wMlA3|ryP MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTR|MECxPUc,OTF2M{CwNVk9N2F-
H9 M{fndmFvfGm4aYLhcEBie3OjeR?= MljHRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCURjDpckBpfW2jbjDIPUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[nliZn;ycYF7[W5vYnHz[YQh[2:wdnXueIlwdmGuIHPvcI9zcW2ndILpZ{B1\WOqbnnxeYUtKEWFNUC9NE4xPs7:TR?= NVHmOGJvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG0N|AxOTlpPkGxOFMxODF7PD;hQi=>
PBMC Ml\KRY51cX[rcnHsJIF{e2G7 MXXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYuOXi6QmLVJI12fGGwdDDzeJJicW5iaX6gbJVu[W5iUFLNJINmdGy|LDDFR|kxRTBwMElOwG0> NIe3U3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkO4N|AyPCd-MUKzPFMxOTR:L3G+
PBMC MUDGeY5kfGmxbjDhd5NigQ>? M4LSSmFkfGm4aYT5JIFo[Wmwc4SgUIFucX[3ZHnu[U1z\XOrc4ThcpQhfmm{dYOgLGhKXi1zWGjCVnUqKGmwIHj1cYFvKFCETTDj[YxteyxiZYjwdoV{e2WmIHHzJGVEPTBuIFXDOVA:OC5yM{ZOwG0> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh3Mke1OUc,OTJ6NUK3OVU9N2F-
PBMC M2nXcGZ2dmO2aX;uJIF{e2G7 Mn7GTY4hfmm2cn:gZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcohq[mm2IITo[UBJUVZvMTDMRVEhemWybHnjZZRqd25ib36gVGJOS3NiY3XscEApeGW{aYDo[ZJidCCkbH;v[EBud26xboXjcIVieiClZXzsd{ktKEWFNUC9NE4xOc7:TR?= NWHlco9nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4OVI6PDNpPkGyPFUzQTR|PD;hQi=>
PBMC NVz3V25iTnWwY4Tpc44h[XO|YYm= MYHF[oZm[3SrdnWgZ49v[2WwdILheIlwdiC2bzDpcohq[mm2IFjJWk0yKEyDSTDjfZRweGG2aHnjbZR6KGmwIGDCUWMh[2WubIOge4F{KGSndHXycYlv\WRiaX6geol1em9uIFXDOVA:OC5yMUG2{txO NH;FVWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEm3NVg6QCd-MUS5O|E5QTh:L3G+
HepG2.2.15 Mon5SpVv[3Srb36gZZN{[Xl? Mn7FSYZn\WO2aY\lJINwdmOnboTyZZRqd25idH:gbY5pcWKrdDDo[ZBifGm2aYOgRkB3cXK3czDjfZRweGG2aHnjbZR6KGmwIFjldGczNjJwMUWgZ4VtdHNid3HzJIRmfGW{bXnu[YQhcW5idnn0do8tKEWFNUC9NE4z|ryP NX3ZSXZuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5O|E5QThpPkG0PVcyQDl6PD;hQi=>
MT-4 NXWxRVBqTnWwY4Tpc44h[XO|YYm= NVLIW4djTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36geI8hcW6qaXLpeEBJUVZvMTDJTWlDKGO7dH;wZZRpcWOrdImgbY4hVVRvNDDj[YxteyC5YYOg[IV1\XKvaX7l[EBqdiC4aYTyc{whTUN3ME2wMlXPxE1? M4XTNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2OUexPFk5Lz5zNEm3NVg6QDxxYU6=
PBMC MUDBcpRqfmm{YXygZZN{[Xl? MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGlXKH[rcoXzLJh5SlKXKTDpckBJfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJEhRSk1rIHPlcIx{NCCHQ{mwQVAvODkQvF2= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB{N{i1OEc,OTVyMke4OVQ9N2F-
PBMC NVfIb2JtTnWwY4Tpc44h[XO|YYm= M1LBSGVn\mWldHn2[UBkd26lZX70doF1cW:wIHHnZYlve3RiV3ns[EBVgXCnIFjJWk0yKH[rcoXzJIlvKGi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIh[2WubIOsJGVEPTB;MD6wOFHPxE1? MkewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVzOEmwN|YoRjF3MUi5NFM3RC:jPh?=
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2.2.15 Mn\DSpVv[3Srb36gZZN{[Xl? M{PVd2Vn\mWldHn2[UBkd26lZX70doF1cW:wczDheEB4cGmlaDCxNE1nd2ymIHTldJJme3Orb36gc4YhcW62cnHj[YxtfWyjcjDpcpRmem2nZHnheIV{KG:oIFjCWkBFVkFid3HzJI9je2W{dnXkJIlvKDJwMj6xOUBE\WyuczygSWM2OD1yLkKz{txO NYPzVmdURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[wN|MzQDNpPkG2NFM{Ojh|PD;hQi=>
2.2.15 NFjHVoZHfW6ldHnvckBie3OjeR?= NWLtVWtTTW[oZXP0bZZmKGOxbnPlcpRz[XSrb37zJIF1KHeqaXPoJFExNW[xbHSg[IVxemW|c3nvckBw\iCrboTyZYNmdGy3bHHyJIlvfGW{bXXkbYF1\XNib3[gTGJXKESQQTD3ZZMhd2K|ZYL2[YQhcW5iMj6yMlE2KEOnbHzzMEBGSzlyPUCuOlnPxE1? NWnOU2dNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[wN|MzQDNpPkG2NFM{Ojh|PD;hQi=>
2.2.15 M3nTfGZ2dmO2aX;uJIF{e2G7 NUL1fZozUW6qaXLpeIlwdiCxZjDzfY51cGW|aYOgc4Yh\Xi2cnHj[YxtfWyjcjD2bZJqd25iRF7BJJJmdGWjc3WgbY4h[3WudIXy[YQhcHWvYX6gbIVx[XSxYnzhd5RwdWFiMj6yMlE2KGOnbHzzMEBGSzVyPUCuNFQ5|ryP NH3ROIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkKxN|cyOyd-MU[yNVM4OTN:L3G+
2.2.15 NUTOdGJbTnWwY4Tpc44h[XO|YYm= NHLqT5RKdmirYnn0bY9vKG:oIIP5cpRp\XOrczDv[kBmgHS{YXPlcIx2dGG{II\pdolwdiCGTlGgdoVt\WG|ZTDpckBkfWy2dYLl[EBpfW2jbjDo[ZBifG:kbHHzeI9u[SB{LkKuNVUh[2WubIOsJGVEQTB;MD6xOVHPxE1? MknNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ{MUO3NVMoRjF4MkGzO|E{RC:jPh?=
2.2.15 NWjTcIZnTnWwY4Tpc44h[XO|YYm= M4THbmlvcGmkaYTpc44hd2Zic4nueIhme2m|IH;mJIlvfHKjY3XscJVt[XJiSFLWJGRPSSC{ZYDsbYNifGm4ZTDpcpRmem2nZHnheIV{KGmwIHP1cJR2emWmIHj1cYFvKGincHH0c4Jt[XO2b33hJFIvOi5zNTDj[YxteyxiRVO1NF0xNjJ3Md88US=> MlPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ{MUO3NVMoRjF4MkGzO|E{RC:jPh?=
2.2.15 MVzGeY5kfGmxbjDhd5NigQ>? MXjJcohq[mm2aX;uJI9nKHO7boTo[ZNqeyCxZjDpcpRz[WOnbHz1cIFzKEiEVjDEUmEhemWybHnjZZRqfmViaX70[ZJu\WSrYYTld{BqdiCldXz0eZJm\CCqdX3hckBp\XCjdH;icIF{fG:vYTCyMlIvOTViY3XscJMtKEWFOUC9NE43PDkQvF2= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjJzM{exN{c,OTZ{MUO3NVM9N2F-
2.2.15 M1m2N2Z2dmO2aX;uJIF{e2G7 MniwTY5pcWKrdHnvckBw\iC5aXzkJJR6eGViSFLWJJRz[W6|ZnXjeIVlKGmwIHj1cYFvKGincHH0c4Jt[XO2b33hJFIvOi5zNTDj[YxteyxiRVO1NF0zNjIQvF2= MkjnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzPVMoRjF4NUO5N|k{RC:jPh?=
hepatoma 2.2.15 MXPBcpRqfmm{YXygZZN{[Xl? MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGJXKGmwIHj1cYFvKGincHH0c41iKDJwMj6xOUBk\WyuczygSWM2OD1{LkJOwG0> NWfjNZJZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3OVkyOTJpPkG2O|U6OTF{PD;hQi=>
2.2.15 MmTnSpVv[3Srb36gZZN{[Xl? NFizOXBKdmirYnn0bY9vKG:oIFjCWkBz\XCuaXPheIlwdiCrbjCyMlIvOTViY3XscJMh[nliRF7BJIh6[nKrZHn6ZZRqd25iYYPzZZktKEWFNUC9NE4xOs7:TR?= MlTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyMES3NlYoRjF5MEC0O|I3RC:jPh?=
MDCK2 NIXle|NHfW6ldHnvckBie3OjeR?= M2PDTVExKHWP NX\PS5R2UW6qaXLpeIlwdiCxZjDoeY1idiCPUmCyJIV5eHKnc4Pl[EBqdiCPRFPLNkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJGNOTiCobIXvdoV{[2WwY3WgZZQhOTBidV2gZpkhS02IRFGgZZN{[Xl? M2DkOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUeyN|EyLz5zN{G3NlMyOTxxYU6=
MDCK2 NVK2e4JPTnWwY4Tpc44h[XO|YYm= NX7VRoRZOTBidV2= NHr5bopKdmirYnn0bY9vKG:oIHj1cYFvKE2UUEOg[ZhxemW|c3XkJIlvKE2GQ1uyJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgR21HKG[udX;y[ZNk\W6lZTDheEAyOCC3TTDifUBEVU[GQTDhd5NigQ>? M{\ob|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUeyN|EyLz5zN{G3NlMyOTxxYU6=
MDCK2 M{XxVWZ2dmO2aX;uJIF{e2G7 NWjhWZJVOTBidV2= MXTJcohq[mm2aX;uJI9nKGi3bXHuJG1TWDFiZYjwdoV{e2WmIHnuJG1FS0t{IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIlvfHKjY3XscJVt[XJiQ13GJIZtfW:{ZYPj[Y5k\SCjdDCxNEB2VSCkeTDDUWZFSSCjc4PhfS=> NXfWOIl4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexO|I{OTFpPkG3NVczOzFzPD;hQi=>
Huh7 MlLxSpVv[3Srb36gZZN{[Xl? M3foRmlvcGmkaYTpc44hd2Zid3ns[EB1gXCnIFjCWkBz\XCuaXPheIlwdiCrbjDIeYg4KGOnbHzzMEBGSzVyPUJOwG0> NF;WVow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O3NVgzPyd-MUezO|E5Ojd:L3G+
PBMC M3nRWmFvfGm4aYLhcEBie3OjeR?= MWTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKEyDSTDpckBpfW2jbjDQRm0h[2WubIOsJGVEPTB;MD6wNlbPxE1? M3Xnb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NECzPVk3Lz5zN{SwN|k6PjxxYU6=
PBMC NEPjXGdCdnSrdnnyZYwh[XO|YYm= MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKEyDSTDpckBpfW2jbjDQRm0h[2WubIOsJGVEQTB;MD6xNu69VQ>? M2O3cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NECzPVk3Lz5zN{SwN|k6PjxxYU6=
HepG2.2.15 MlXCRY51cX[rcnHsJIF{e2G7 NF\3fXBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX6gTIVxTzJwMj6xOUBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCneITyZYNmdGy3bHHyJJZqemGuIFTORUBt\X[nbDDifUBTXC2SQ2KsJGVEPTB;MD6x{txO NX7EW3NoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NFQxODZpPkG3OFA1ODB4PD;hQi=>
Huh7 NX\EUGI4SW62aY\pdoFtKGG|c3H5 MWm1JIRigXN? NHzWdlNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiZ3Xuc5R6eGViRDD3bZRpKHKndnXyd4UhfHKjboPjdolxfGG|ZTDMPFBKKG23dHH0bY9vKGmwIHj1cYFvKEi3aEegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA2KGSjeYOsJGVEPTB;MD6wN:69VQ>? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR|OEC0O{c,OTd2M{iwOFc9N2F-
Huh7 MkXKRY51cX[rcnHsJIF{e2G7 MkfCOUBl[Xm| Mnj6RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJmSWdvZHXmbYNq\W62IFjCWkBo\W6xdInw[UBFKHerdHigdJJm[2:{ZTDHNVg6PkFibYX0ZZRqd25iYX7kJJJmfmW{c3WgeJJidnOlcnnweIF{\SCOOEDJJI12fGG2aX;uJIlvKGi3bXHuJGh2cDdiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjC1JIRigXNuIFXDOVA:OC5yM988US=> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR|OEC0O{c,OTd2M{iwOFc9N2F-
Huh7 NWTpUHMySW62aY\pdoFtKGG|c3H5 NF\lbXo2KGSjeYO= NX6z[nd{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHflco91gXCnIFSgbY4hcHWvYX6gTJVpPyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEWg[IF6eyxiRVO1NF0xNjRzzszN NIrQblg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SzPFA1Pyd-MUe0N|gxPDd:L3G+
Huh7 MkWzRY51cX[rcnHsJIF{e2G7 MYO1JIRigXN? NVLEb|VvSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKnQXet[IVncWOrZX70JGhDXiCpZX7veJlx\SCGIIfpeIgheHKnY3;y[UBIOTh7NlGgcZV1[XSrb36gbY4hcHWvYX6gTJVpPyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEWg[IF6eyxiRVO1NF0xNjR4zszN M{ezR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEO4NFQ4Lz5zN{SzPFA1PzxxYU6=
HepG2(2.2.15) M2XkPWFvfGm4aYLhcEBie3OjeR?= MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW5iYYn3JJdqdGRidInw[UBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygSG5CKHKncHzpZ4F1cW:wLDDJR|UxRTBwMEZOwG0> NGX3O4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S4PFgyPyd-MUe0PFg5OTd:L3G+
HepG2(2.2.15) NWfkXnBwTnWwY4Tpc44h[XO|YYm= MleyTY5pcWKrdHnvckBw\iCKQm[gdJJwdW:2ZYKgbY4hcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MD6wPO69VQ>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR6OEixO{c,OTd2OEi4NVc9N2F-
HepW10 MlntRY51cX[rcnHsJIF{e2G7 MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW5iYXTybYFugWOrbj3y[ZNqe3SjboSge4lt\CC2eYDlJGhmeFdzMDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJGRPSSC{ZYDsbYNifGmxbjygTWM2OD1yLkJOwG0> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR6OEixO{c,OTd2OEi4NVc9N2F-
HBV-Met MlrJRY51cX[rcnHsJIF{e2G7 NXiwZXVzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnuJI1wfXOnIHH5e{B4cWymIIT5dIUhUEKYLV3leEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKESQQTDy[ZBtcWOjdHnvckwhUUN3ME2wMlLPxE1? NIrXPIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S4PFgyPyd-MUe0PFg5OTd:L3G+
HepG2.2.15 NFLxS2hHfW6ldHnvckBie3OjeR?= NIr0[FQ5KGSjeYO= NHnZNmNKdmirYnn0bY9vKG:oIHP5eI9xdGG|bXnjJGhDXiCGTlGgd5lvfGinc3nzJIlvKEincFeyMlIvOTViY3XscJMh[W[2ZYKgPEBl[Xm|LDDJR|UxRTBwM{lOwG0> NWjVcGNuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVk5QDlpPkG3OFk6QDh7PD;hQi=>
PBMC NHfteVdHfW6ldHnvckBie3OjeR?= MlrtN|AxKG2p M4[zR|ch\GG7cx?= MmfHR41igCCrbjDITXYucW6oZXP0[YQhcHWvYX6gZZN{\XO|ZXSgZZMhVGGvaY\1[Ilv\SCvb37vdIhwe3CqYYTlJIxmfmWuIHnuJHBDVUNiYYSgN|AxKG2pIGHEJIZweiB5IHThfZMhdWWjc4Xy[YQheGW{IEGwK|Yh[2WubIOgbY4heHKnc3XuZ4Uhd2Ziennkc5Z2\GmwZTygR41igD1yLkCwNFAxODkQvF2= MkfoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkSzNlgoRjF5Nk[0N|I5RC:jPh?=
PBMC M{C0eGZ2dmO2aX;uJIF{e2G7 MnrEN|AxKG2p M13vW|ch\GG7cx?= MkL0R41igCCrbjDITXYucW6oZXP0[YQhcHWvYX6gZZN{\XO|ZXSgZZMhVGGvaY\1[Ilv\SCmaYDoc5NxcGG2ZTDs[ZZmdCCrbjDQRm1EKGG2IEOwNEBu\yCTRDDmc5IhPyCmYYnzJI1m[XO3cnXkJJBmeiBzMDe2JINmdGy|IHnuJJBz\XOnbnPlJI9nKHqrZH;2eYRqdmVuIFPtZZg:OC5yMECwNFQ1|ryP NUSyR3ZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2OlQ{OjhpPkG3OlY1OzJ6PD;hQi=>
PBMC MoTmSpVv[3Srb36gZZN{[Xl? M2jI[lMxOCCvZx?= NHPDTmE4KGSjeYO= MYnDcYF5KGmwIFjJWk1qdm[nY4Tl[EBpfW2jbjDhd5Nme3OnZDDhd{BN[W2rdoXkbY5mKHS{aYDoc5NxcGG2ZTDs[ZZmdCCrbjDQRm1EKGG2IEOwNEBu\yCTRDDmc5IhPyCmYYnzJI1m[XO3cnXkJJBmeiBzMDe2JINmdGy|IHnuJJBz\XOnbnPlJI9nKHqrZH;2eYRqdmVuIFPtZZg:OC5yMECwNFQ5|ryP MoXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkSzNlgoRjF5Nk[0N|I5RC:jPh?=
MAGIC-5A M4\W[GFvfGm4aYLhcEBie3OjeR?= NXO1OmhLPDBiaILz NIfxT5VCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymIIT5dIUhUEmYMTDOUFQuOyCycn;keYNm\CCocn;tJIZ2dGxibHXu[5RpKHCUOXTlcJRiSXCjIHnu[oVkfGWmIHnuJIh2dWGwIF3BS2lENTWDIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhVGGlKzDmc4NqKGW6cILld5Nqd25iYX\0[ZIhPDBiaILzMEBGSzVyPUCuPFjPxE1? MnHSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7Nke5NVMoRjF5OU[3PVE{RC:jPh?=
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MT2 NW[3UlYzSW62aY\pdoFtKGG|c3H5 MUe1JIRigXN? M17CRWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFAvODViTV;JJJdqdGRidInw[UBJUVZzIF7MOE0{KGmwZnXjeIVlKGmwIEKgbJIueHKndILlZZRm\CCqdX3hckBOXDJiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgOUBl[Xm|IHL5JG1VWyCjc4PhfUwhTUN3ME2zMlI1P87:TR?= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzNkWyNUc,OTh|MU[1NlE9N2F-
HepG2(2.2.15) M2\6SWFvfGm4aYLhcEBie3OjeR?= M4fXTFI1KGi{cx?= MWrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDlfJRz[WOnbHz1cIFzKEiEVjD2bZJqd25iRF7BJIxmfmWuIHHmeIVzKDJ2IHjyd{whTUN3ME2wMlA1QM7:TR?= NYfoOJpWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwO|I3QTRpPkG5NFczPjl2PD;hQi=>
HepG2(2.2.15) NV65O3I4SW62aY\pdoFtKGG|c3H5 NWfNOYE3OjRiaILz MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDy[ZBtcWOjdHnvckBqdnSncn3l[IlifGW|IHHmeIVzKDJ2IHjyd{whTUN3ME2wMlE2|ryP M2XN[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7 NWDFRpRMSW62aY\pdoFtKGG|c3H5 Mmi2OEBl[Xm| NESwSXhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBt[W2rdoXkbY5mNXKnc3nzeIFvfCC5aXzkJJR6eGViSFLWJIlvKGi3bXHuJGh2cDdiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JIlvfHKjY3XscJVt[XJiSFLWJGRPSSC{ZYDsbYNifGmxbjDhd5NigSxiRVO1NF0xNjMQvF2= NIrQN2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 NFXWO3NCdnSrdnnyZYwh[XO|YYm= NWLBUYxiPCCmYYnz NWq0bmY{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhdGGvaY\1[Ilv\S2{ZYPpd5RidnRiSFLWJJJmfmW{c3WgeJJidnOlcnnweIF{\SB{M{\UJI12fGGwdDDpckBpfW2jbjDIeYg4KGOnbHzzJIFnfGW{IESg[IF6eyCkeTDpcpRz[WOnbHz1cIFzKEiEVjDEUmEhemWybHnjZZRqd25iYYPzZZktKEWFNUC9NE4{|ryP M2G1S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7 MU\BcpRqfmm{YXygZZN{[Xl? MnzFOEBl[Xm| MYfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IVnd3[rcj3y[ZNqe3SjboSge4lt\CC2eYDlJGhDXiCrbjDoeY1idiCKdXi3JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO|YYmsJGVEPTB;MT6z{txO NHfxfWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 NF3wUnFCdnSrdnnyZYwh[XO|YYm= MUG0JIRigXN? MlPxRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRm\m:4aYKtdoV{cXO2YX70JGhDXiC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUVIxPFZibYX0ZY51KGmwIHj1cYFvKEi3aEegZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KGmwdILhZ4VtdHWuYYKgTGJXKESQQTDy[ZBtcWOjdHnvckBie3OjeTygSWM2OD1zLkZOwG0> MnnXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
Huh7 MmXERY51cX[rcnHsJIF{e2G7 Mo\5OEBl[Xm| MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IVnd3[rcj3y[ZNqe3SjboSgTGJXKHKndnXyd4UhfHKjboPjdolxfGG|ZTDMNVgxVSCvdYThcpQhcW5iaIXtZY4hUHWqNzDj[YxteyCjZoTldkA1KGSjeYOgZpkhcW62cnHj[YxtfWyjcjDIRnYhTE6DIILldIxq[2G2aX;uJIF{e2G7LDDFR|UxRTFwNt88US=> NYn2UndTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwO|I3QTRpPkG5NFczPjl2PD;hQi=>
Huh7 NETCcodCdnSrdnnyZYwh[XO|YYm= MVu0JIRigXN? M3TncmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl\W[xdnnyMZJme2m|dHHueEBJSlZicnX2[ZJ{\SC2cnHud4NzcXC2YYPlJGxON3KndnXyd4UhfHKjboPjdolxfGG|ZTDNWkBld3WkbHWgcZV1[W62IHnuJIh2dWGwIFj1bFch[2WubIOgZYZ1\XJiNDDkZZl{KGK7IHnueJJi[2WubIXsZZIhUEKYIFTORUBz\XCuaXPheIlwdiCjc4PhfUwhTUN3ME2xMlbPxE1? MmnOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
Huh7 NU[yR|NTSW62aY\pdoFtKGG|c3H5 MX20JIRigXN? MmTrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRm\m:4aYKtdoV{cXO2YX70JGhDXiC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUVIxPElibYX0ZY51KGmwIHj1cYFvKEi3aEegZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KGmwdILhZ4VtdHWuYYKgTGJXKESQQTDy[ZBtcWOjdHnvckBie3OjeTygSWM2OD1zLklOwG0> Mn3IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
Huh7 MXnBcpRqfmm{YXygZZN{[Xl? NUHKSoJzPCCmYYnz M1T2cGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl\W[xdnnyMZJme2m|dHHueEBJSlZicnX2[ZJ{\SC2cnHud4NzcXC2YYPlJFI{PlRibYX0ZY51KGmwIHj1cYFvKEi3aEegZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KGmwdILhZ4VtdHWuYYKgTGJXKESQQTDy[ZBtcWOjdHnvckBie3OjeTygSWM2OD15LkhOwG0> NHzaW|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 MXPBcpRqfmm{YXygZZN{[Xl? MUG0JIRigXN? NHrPS4hCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBt[W2rdoXkbY5mNXKnc3nzeIFvfCCKQm[gdoV3\XK|ZTD0doFve2O{aYD0ZZNmKExzOEDNJI12fGGwdDDpckBpfW2jbjDIeYg4KGOnbHzzJIFnfGW{IESg[IF6eyCkeTDpcpRz[WOnbHz1cIFzKEiEVjDEUmEhemWybHnjZZRqd25iYYPzZZktKEWFNUC9NVDPxE1? NF;3[289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
HuH7 MnfSRY51cX[rcnHsJIF{e2G7 Mn7xNlQhcHK| NHO3O|JCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymIIT5dIUhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFj1TFch[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5idnnyZYwhfHKjboPp[Y51KHS{YX7z[oVkfGmxbjDh[pRmeiB{NDDodpMtKEWFNUC9NE4z|ryP NEfDUFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7 NUXBOGV2SW62aY\pdoFtKGG|c3H5 NGG4dJUzPCCqcoO= NWjrelY3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHjhdoJwemmwZzDSUmEheG:ueX3ldoF{\SCQMkO2WEBufXSjboSg[4Vv\SCrbn\lZ5Rm\CCrbjDoeY1idiCKdVi3JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKH[rcnHsJJRz[W6|aXXueEB1emGwc3\lZ5Rqd25iYX\0[ZIhOjRiaILzMEBGSzVyPUCuN:69VQ>? NGfKTIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7 M3jqR2FvfGm4aYLhcEBie3OjeR?= MW[yOEBpenN? M2fVb2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCqYYLic5JqdmdiUl7BJJBwdHmvZYLhd4UhVjJ|NmSgcZV1[W62IHflcoUhcW6oZXP0[YQhcW5iaIXtZY4hUHWKNzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckB3cXKjbDD0doFve2mnboSgeJJidnOoZXP0bY9vKGGodHXyJFI1KGi{czygSWM6OD1zLkZOwG0> NF3FeFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7 NIHCbIpCdnSrdnnyZYwh[XO|YYm= NHfsR5czPCCqcoO= MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEi3SEegZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hfmm{YXygeJJidnOrZX70JJRz[W6|ZnXjeIlwdiCjZoTldkAzPCCqcoOsJGVEQTB;M988US=> NFXXV449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7 NVX4V2pvSW62aY\pdoFtKGG|c3H5 MnPINlQhcHK| M{HURmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCqYYLic5JqdmdiUl7BJJBwdHmvZYLhd4UhVDF6MF2gcZV1[W62IHflcoUhcW6oZXP0[YQhcW5iaIXtZY4hUHWKNzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckB3cXKjbDD0doFve2mnboSgeJJidnOoZXP0bY9vKGGodHXyJFI1KGi{czygSWM2OD1zNt88US=> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7OE[0PEc,OTl|OUi2OFg9N2F-
HuH7 MULBcpRqfmm{YXygZZN{[Xl? Mm\ZNlQhcHK| Mn;xRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGijcnLvdolv\yCUTlGgdI9tgW2ncnHz[UBNOThyTTDteZRidnRiZ3Xu[UBqdm[nY4Tl[EBqdiCqdX3hckBJfUh5IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJZqemGuIITyZY5{cWWwdDD0doFve2[nY4Tpc44h[W[2ZYKgNlQhcHK|LDDFR|kxRTRzzszN MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7OE[0PEc,OTl|OUi2OFg9N2F-
MT2 NYfaUmR7SW62aY\pdoFtKGG|c3H5 M2S4bWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiaX7m[YN1\WRiaX6gbJVu[W5iTWSyJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25uIFnDOVA:OC54zszN MlzhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3OU[4PFUoRjF7NUm2PFg2RC:jPh?=
HeLa P4/R5 NXTrdm5ySW62aY\pdoFtKGG|c3H5 M1jmTWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiaX7m[YN1\WRiaX6gbJVu[W5iSHXMZUBRPC:UNTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vNCCLQ{WwQVAvPzkQvF2= Mn;IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3OU[4PFUoRjF7NUm2PFg2RC:jPh?=
TZM-bl NV\CZ5BOSW62aY\pdoFtKGG|c3H5 NYXpbHR1PzJiaILz NUWxXZpYSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDwUmw1NTNiaHHyZo9zcW6pIGLleoVze2VidILhcpNkemmydHHz[UBROTF7UzDteZRidnRiZ3Xu[UBqdm[nY4Tl[EBqdiCWWl2tZowh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHz1Z4ln\XKjc3WgZZN{[XluIFXDOVA:OC52N988US=> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTdyNEGzNUc,OTl5MESxN|E9N2F-
TZM-bl MUTBcpRqfmm{YXygZZN{[Xl? NXy2XmdPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZD30fZBmKEiLVkGgdG5NPC1|IHnu[oVkfGWmIHnuJHRbVS2kbDDj[YxteyCkeTDseYNq\mW{YYPlJIF{e2G7LDDFR|UxRTBwNkZOwG0> NGXkNG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUewOFE{OSd-MUm3NFQyOzF:L3G+
TZM-bl NWHVSlRFSW62aY\pdoFtKGG|c3H5 MnT5O|IhcHK| MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKHCQTEStN{Bp[XKkb4LpcochWmW4ZYLz[UB1emGwc3PybZB1[XOnIGSxOlVCKG23dHHueEBo\W6nIHnu[oVkfGWmIHnuJHRbVS2kbDDj[YxteyCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhTUN3ME2xMlA5|ryP MlXIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5MESxN|EoRjF7N{C0NVMyRC:jPh?=
TZM-bl MX7BcpRqfmm{YXygZZN{[Xl? MX:3NkBpenN? MlztRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCyTly0MVMhcGG{Yn;ybY5oKFKndnXyd4UhfHKjboPjdolxfGG|ZTDQNVE6Wy:WMU[1RUBufXSjboSg[4Vv\SCrbn\lZ5Rm\CCrbjDUXm0u[mxiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIx2[2moZYLhd4Uh[XO|YYmsJGVEPTB;Mj6x{txO Mn:5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5MESxN|EoRjF7N{C0NVMyRC:jPh?=
HepG2.2.15 MojCRY51cX[rcnHsJIF{e2G7 MXPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KuNk4yPSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIFTORUBz\XCuaXPheIlwdixiSVO1NF0xNjJ{zszN NVvqO5ZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4PVc{PjNpPkG5PFk4OzZ|PD;hQi=>
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HepG2.2.15 M{PrW2FvfGm4aYLhcEBie3OjeR?= M1XPUFkh\GG7cx?= NUDqZpdHSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiEVjDpcoZm[3SnZDDpckBJ\XCJMj6yMlE2KGOnbHzzJIF{e2W|c3XkJIF{KG63Y3zlbYMh[WOrZDDhcoQheHKxdHXpckBt\X[nbIOg[I9{\WRiZHHpcJkh\m:{IEmg[IF6eyCjbnSgcYVie3W{ZXSgNlQhcHK|IHHmeIVzKGyjc4SgeJJm[XSvZX70JIJ6KFOxdYTo[ZJvKGKub4SgbJljemmmaYrheIlwdixiRVO1NF0xNjMQvF2= NIj6eoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGxO|k{OCd-MkCxNVc6OzB:L3G+
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Huh7 M1f6U2FvfGm4aYLhcEBie3OjeR?= M{X1dGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIxidWm4dXTpcoUuemW|aYP0ZY51KHerbHSgeJlx\SCqZYDheIl1cXNiQjD2bZJ2eyCrbn\lZ5Rm\CCrbjDoeY1idiCKdXi3JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC|ZXPy[ZRm\CCGTlGgcIV3\Wy|IH3lZZN2emWmIH;uJIRigSB5IHL5JJJm[WxvdHnt[UBRS1JiYX7hcJl{cXNuIFXDOVA:OC5yNUZOwG0> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6MkC2PEc,OjhyOEKwOlg9N2F-
HepG2.215 NY\jbWQ1SW62aY\pdoFtKGG|c3H5 NWPQXIxJSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcGWyYYTpeIl{KEJidnnyeZMhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KuNlE2KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCCGTlGgdoVxdGmlYYTpc44hdWWjc4Xy[YQhd25iZHH5JFch[nlicnXhcEB1cW2nIGDDVkBidmGueYPpd{whTUN3ME2wMlHPxE1? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6MkC2PEc,OjhyOEKwOlg9N2F-
Huh7 NFf1fIhCdnSrdnnyZYwh[XO|YYm= NVXEc4pWSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhdGGvaY\1[Ilv\S2{ZYPpd5RidnRid3ns[EB1gXCnIHjldIF1cXSrczDCJJZqenW|IHnu[oVkfGWmIHnuJIh2dWGwIFj1bFch[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHnueJJi[2WubIXsZZIhTE6DIHzleoVteyCvZXHzeZJm\CCxbjDkZZkhPyCkeTDy[YFtNXSrbXWgVGNTKGGwYXz5d4l{NCCHQ{WwQVAvOjN5zszN M1jMXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEiyNFY5Lz5{OEC4NlA3QDxxYU6=
HepG2.215 M1vmeWFvfGm4aYLhcEBie3OjeR?= M13mVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{LkKxOUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwhTE6DIILldIxq[2G2aX;uJI1m[XO3cnXkJI9vKGSjeTC3JIJ6KHKnYXygeIlu\SCSQ2KgZY5idHm|aYOsJGVEQTB;Mt88US=> NX6zOJJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFIxPjhpPkK4NFgzODZ6PD;hQi=>
HepAD38 MXjBcpRqfmm{YXygZZN{[Xl? NEXqZ|I2KGSjeYO= NHfHRZlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwRWQ{QCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGRPSSC{ZYDsbYNifGmxbjDh[pRmeiB3IHThfZMh[nliUmStVGNTKG2ndHjv[EwhTUN3ME2wMlA1|ryP M{C1PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEm0NVc6Lz5{OEC5OFE4QTxxYU6=
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P4R5 MAGI MmP3SpVv[3Srb36gZZN{[Xl? NWXITWZIOiCqcoO= NGP3WHZKdmirYnn0bY9vKG:oIFjJWlEhO0JiZHnueYNt\W:|aXTlJJJmfmW{c3WgeJJidnOlcnnweIF{\SCrbn\lZ5Rm\CCrbjDoeY1idiCSNGK1JG1CT0liY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuIHnu[oVkfGmxbjDh[pRmeiB{IHjyd{BjgSCJYXzhZ5RwNVO2YYKgZoV1[S2pYXzhZ5Rwe2mmYYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9N|IvP87:TR?= MojxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|NUG1PFgoRjJ6M{WxOVg5RC:jPh?=
HepG2.2.15 M2HwU2FvfGm4aYLhcEBie3OjeR?= M3HnOVgh\GG7cx?= MVPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZBifGm2aYOgRkB3cXK3czDpcoZm[3SnZDDpckBpfW2jbjDI[ZBIOi5{LkG1JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhTE6DIILldIxq[2G2aX;uJIFnfGW{IEig[IF6eyCkeTDy[YFtKHSrbXWg[ox2d3Knc3PlcpQhWEOUIH3leIhw\CxiSVO1NF0xNjYQvF2= NGfYNHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES5OFI2Oid-Mki0PVQzPTJ:L3G+
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HepG2(2.2.15) M2jEUmFvfGm4aYLhcEBie3OjeR?= MVG2JIRigXN? Mor3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGG7d{GgbY5n\WO2ZXSgbY4hcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxicnXwcIlk[XSrb36gZpkhdWWjc4XybY5oKGmwdILhZ4VtdHWuYYKgeolz[WxiRF7BJINweHliboXtZoVzKGGodHXyJFYh\GG7czDifZIh[nlicnXhcE11cW2nIIHQR3Ih[XO|YYmsJGVEPTB;MD6wNFg5P87:TR?= M362SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkiyNFY4Lz5{OE[4NlA3PzxxYU6=
HepG2(2.2.15) NILLR2hCdnSrdnnyZYwh[XO|YYm= NEL6NWE3KGSjeYO= Ml7vRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGG7d{GgbY5n\WO2ZXSgbY4hcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxicnXwcIlk[XSrb36gZpkhdWWjc4XybY5oKGW6dILhZ4VtdHWuYYKgeolz[WxiRF7BJINweHliboXtZoVzKGGodHXyJFYh\GG7czDifUBz\WGuLYTpcYUheVCFUjDt[ZRpd2RuIFXDOVA:OC5yMt88US=> NH7RVGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[4NlA3Pyd-Mki2PFIxPjd:L3G+
HepAD38 MYTBcpRqfmm{YXygZZN{[Xl? MmnqRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN|gh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHnueJJi[2WubIXsZZIhfmm{YXygSG5CKGyndnXsJIJ6KFKWLWDDVkBu\XSqb3SsJGVEPTB:MD6wNe69VQ>? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6OEK4NEc,Ojh4OEiyPFA9N2F-
HepAD38 M33YN2FvfGm4aYLhcEBie3OjeR?= NGrNVoNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwRWQ{QCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxicnXwcIlk[XSrb36gZpkhWlRvUFPSJI1mfGixZDygSWM2OD1yLkC0{txO M376PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Nki4NlgxLz5{OE[4PFI5ODxxYU6=
HepAD38 NIKxZpNCdnSrdnnyZYwh[XO|YYm= MnvwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN|gh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHX4eJJi[2WubIXsZZIhfmm{YXygSG5CKGyndnXsJIJ6KFKWLWDDVkBu\XSqb3SsJGVEPTB;MD6wOO69VQ>? MkXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEiyPFAoRjJ6Nki4NlgxRC:jPh?=
HepAD38 NXnRNotSSW62aY\pdoFtKGG|c3H5 MkSzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN|gh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdoFtKHKncHzpZ4F1cW:wIHL5JHJVNVCFUjDt[ZRpd2RuIFXDPVA:OC5|zszN NFHTO5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[4PFI5OCd-Mki2PFgzQDB:L3G+
HepAD38 MUXBcpRqfmm{YXygZZN{[Xl? NFyzZmlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwRWQ{QCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6g[Zh1emGlZXzseYxieiC4aYLhcEBFVkFibHX2[Ywh[nliUmStVGNTKG2ndHjv[EwhTUN7ME2wMlPPxE1? MljmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEiyPFAoRjJ6Nki4NlgxRC:jPh?=
HepAD38 M1jrTmFvfGm4aYLhcEBie3OjeR?= NVe2bmlESW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFjldGFFOzhiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJIlvfHKjY3XscJVt[XJidnnyZYwhTE6DIHzleoVtKGK7IGLUMXBEWiCvZYToc4QtKEWFOUC9NE44|ryP MlK0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEiyPFAoRjJ6Nki4NlgxRC:jPh?=
SupT1 M2HCdmFvfGm4aYLhcEBie3OjeR?= MXq0PEBpenN? MVTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDWV3YuTyCyc3X1[I91gXCnZDDITXYyKGmwZnXjeIVlKGmwIHj1cYFvKFO3cGSxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MD6x{txO M1:5SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEG2NVMyLz5{OUCxOlE{OTxxYU6=
HepG2(2.2.15) M2rFc2FvfGm4aYLhcEBie3OjeR?= NU\6NIRbPiCmYYnz NGDFS4ZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwS|IpOi5{LkG1LUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKESQQTDy[ZBtcWOjdHnvckBi\nSncjC2JIRigXNiYomgVnQuWEOUIH3leIhw\CxiSVO1NFwxNjIQvF2= M2SwS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki4PVQ{Lz5{OUK4PFk1OzxxYU6=
A549 NHT2NFJCdnSrdnnyZYwh[XO|YYm= MkjVRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSC4aYLpc45{KGSncnn2[YQh\nKxbTDITXYwXlOJLVegc5IhUEmYL1jBJJZqemmxboOgbY5n\WO2ZXSgNlk{XCClZXzsd{B2e2mwZzDoeY1idiCDNUS5JINmdGy|IHHzJJRiemendDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKHW|aX7nJINwdXCxdX7kJJBz\S2vaYjl[EB3cXKrb37zJIZwdGyxd3XkJIJ6KGmwY4XiZZRqd25id3n0bEB1[XKpZYSgZ4VtNCCLQ{WwQVAvPTIQvF2= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ7OUmyOEc,Ojl4OUm5NlQ9N2F-
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... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 46 mg/mL (200.64 mM)
Water 46 mg/mL (200.64 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 229.26
Formula

C8H11N3O3S

CAS No. 134678-17-4
Storage powder
in solvent
Synonyms GR109714X
Smiles C1C(OC(S1)CO)N2C=CC(=NC2=O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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    Volume
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04133012 Recruiting Other: Samplings HIV-1 Infection ANRS Emerging Infectious Diseases|ViiV Healthcare February 10 2020 Not Applicable
NCT03869944 Recruiting Drug: Lamivudine Oral Solution HIV-1 ANRS Emerging Infectious Diseases|Institut National de la Santé Et de la Recherche Médicale France|Centre Muraz December 4 2019 Phase 2
NCT03870438 Recruiting Drug: Lamivudine Oral Solution HIV-1 ANRS Emerging Infectious Diseases|University Teaching Hospital Lusaka Zambia|Centre Muraz|Institut National de la Santé Et de la Recherche Médicale France|University of Bergen December 14 2019 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Reverse Transcriptase Signaling Pathway Map

Related Reverse Transcriptase Products

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID