Lamivudine (BCH-189)

Name: Lamivudine (BCH-189)
Brand: Selleck Chemicals
SKU: S1706
Rating: 5 (9 reviews)

For research use only.

Catalog No.S1706 Synonyms: GR109714X

9 publications

CAS No. 134678-17-4

Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

Selleck's Lamivudine (BCH-189) has been cited by 9 publications

Front Cardiovasc Med, 2021, 8:634774

PubMed: 33898535 ( click the link to review the publication )

ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536

PubMed: 33346662 ( click the link to review the publication )

Antiviral Res, 2020, 175:104709

PubMed: 31940474 ( click the link to review the publication )

Viruses, 2020, 12(9)E928

PubMed: 32846983 ( click the link to review the publication )

Viruses, 2020, 12(10)E1178

PubMed: 33080984 ( click the link to review the publication )

JCI Insight, 2019, 4(12)

PubMed: 31217351 ( click the link to review the publication )

Nat Immunol, 2019, 20(12):1681-1691

PubMed: 31636462 ( click the link to review the publication )

Oncotarget, 2017, 8(15):24694-24705

PubMed: 28445966 ( click the link to review the publication )

Invest Ophthalmol Vis Sci, 2015, 56(12):7122-9

PubMed: 26529046 ( click the link to review the publication )

1 Customer Review

The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.

Oncotarget, 2017, 8(15):24694-24705. Lamivudine (BCH-189) purchased from Selleck.

Purity & Quality Control

Choose Selective Reverse Transcriptase Inhibitors

Biological Activity

Description

Targets

Reverse transcriptase ^[1]

In vitro

Lamivudine’s anti- HBV activity, like its anti-HIV activity, has been shown to depend on the ability of LMV-TP to serve as both substrate and inhibitor of the DNA- and RNA-dependent polymerase activities of the HBV P gene product. Lamivudine owes its activity to the remarkably broad substrate specificity of deoxycytidine kinase and the unusual substrate preference of the HBV polymerases for dNTPs with the unnatural L-conformation, whereas the anti-HBV activity of PCV appears to depend on several factors including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity) by key cellular enzymes, the long intracellular half-life of PCV-TP and the ability of PCV-TP to inhibit the HBV RT priming reaction as well as RT and DNA polymerase activity. ^[1] Lamivudine and Penciclovir inhibits duck hepatitis B virus (DHBV) replication to a comparable extent when used alone, and in combination, the two nucleoside analogs acts synergistically over a wide range of clinically relevant concentrations. Lamivudine combined with Penciclovir is more effective in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV than either drug alone. ^[2] Lamivudine inhibits p24 antigen production by HIV-I in PBMC, with ED50s ranging from 0.07 μM to 0.2 μM. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
MT-4	NVfETmxKTnWwY4Tpc44h[XO\|YYm=			NHnFWpNEd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgd5lvfGmlYTDmc5Ju[XSrb36gZpkhPTBnIHnuJGhKXi1zIHnu[oVkfGWmIF3UMVQh[2WubIOsJGlEPTB;MD6x{txO	NFz5W4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96MEO1OFI6Lz56MEO1OFI6RC:jPh?=
PBMC	NVfVfoxVTnWwY4Tpc44h[XO\|YYm=			M4P0TmNwdmOnboTyZZRqd25icnXxeYlz\WRiZn;yJIFvfGm4aYLhcEBi[3Srdnn0fUBqdiCSQl3DJEhpfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJINmdGy\|KTDpcoZm[3SnZDD3bZRpKEiLVj2xJJN1emGrbjDMRXYtKEWFNUC9NE4xODF6zszN	M3fpXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh2MUC5O\|UoRjh2MUC5O\|U9N2F-
PBMC	MYHGeY5kfGmxbjDhd5NigQ>?			NV7TZYV5S2:wY3XueJJifGmxbjDy[ZF2cXKnZDDmc5Ih[W62aY\pdoFtKGGldHn2bZR6KGmwIGDCUWMhMGi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIh[2WubIOpJIlv\mWldHXkJJdqfGhiSFnWMVEhe3S{YXnuJGxCXixiRVO1NF0xNjJzzszN	MlTUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDRzMEm3OUc,QDRzMEm3OVww[T5?
PBMC	NX\tT3JDSW62aT3ITXYuOSCjc4PhfS=>			MX;BcpRqNUiLVj2xJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjCoVGJOMSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjJWk0yKHO2cnHpckBNSVZuIFXDOVA:OC5yMEG4{txO	NGPSUlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NEKzOVkyLz56NEKzOVkyRC:jPh?=
PBMC	M2jMZWFvfGlvSFnWMVEh[XO\|YYm=			MUHBcpRqNUiLVj2xJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjCoVGJOMSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjJWk0yKHO2cnHpckBNSVZuIFXDOVA:OC5yNt88US=>	NX\Rd\|BRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOESyN\|U6OSd-OESyN\|U6OTxxYU6=
PBMC	MmntRY51cS2KSW[tNUBie3OjeR?=			MXjBcpRqNUiLVj2xJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjCoVGJOMSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjJWk0yKHO2cnHpckBNSVZuIFXDOVA:OC5{Md88US=>	NGP4WVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NEKzOVkyLz56NEKzOVkyRC:jPh?=
PBMC	MmjRRY51cS2KSW[tNUBie3OjeR?=			NIr6dpdCdnSrLVjJWk0yKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkApWEKPKTDj[YxteyCrbn\lZ5Rm\CC5aYToJGhKXi1zIIP0doFqdiCOQW[sJGVEPTB;MUCuNe69VQ>?	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85PDJ\|NUmxK\|45PDJ\|NUmxQE9iRg>?
2.2.15	M4Loc2Z2dmO2aX;uJIF{e2G7			MmDlTY4hfmm2cn:g[YZn\WO2aY\lJINwdmOnboTyZZRqd25iYXfhbY5{fCCqZYDheIl1cXNiQjD2bZJ2eyC5YYOg[IV1\XKvaX7l[EBqdiB{LkKuNVUh[2WubIOsJGVEPTB;MD6wNFjPxE1?	M4LxUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl\|MEG2OVkoRjl\|MEG2OVk9N2F-
PBMC	NGjqeXlCdnSrLVjJWk0yKGG\|c3H5			NW\keYVyUW5idnn0do8h[W62aT3ITXYh[WO2aY\peJkhcW5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjDj[YxteyxiRVO1NF0xNjB5zszN	NFPMdG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97M{CxOlU6Lz57M{CxOlU6RC:jPh?=
2.2.15	M{fJWGFvfGm4aYLhcEBie3OjeR?=			MlG3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVx[XSrdHnzJGIhfmm{dYOgLGhDXiliaX6gNk4zNjF3IHPlcIx{NCCHQ{WwQVAvODB6zszN	M2PUVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEWyO\|k2Lz5zMUC1Nlc6PTxxYU6=
PBMC	M3\IT2FvfGm4aYLhcEBie3OjeR?=			M4nIc2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGludXWwb3Tl[olkcWWwY4mgeolzfXNidInw[U0yKCiKSW[tNUkhcW5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjDj[YxteyxiRVO1NF0xNjB5zszN	MmiwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyNUK3PVUoRjFzMEWyO\|k2RC:jPh?=
H9	M2\qR2FvfGm4aYLhcEBie3OjeR?=			MXHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYyKDOEIHnuJIh2dWGwIFi5JINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBjgSCob4LtZZpidi2kYYPl[EBkd264ZX70bY9v[WxiY3;sc5JqdWW2cnnjJJRm[2iwaYH1[UwhTUN3ME2wMlA3\|ryP	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTR\|MECxPUc,OTF2M{CwNVk9N2F-
H9	M{fndmFvfGm4aYLhcEBie3OjeR?=			MljHRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCURjDpckBpfW2jbjDIPUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[nliZn;ycYF7[W5vYnHz[YQh[2:wdnXueIlwdmGuIHPvcI9zcW2ndILpZ{B1\WOqbnnxeYUtKEWFNUC9NE4xPs7:TR?=	NVHmOGJvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG0N\|AxOTlpPkGxOFMxODF7PD;hQi=>
PBMC	Ml\KRY51cX[rcnHsJIF{e2G7			MXXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYuOXi6QmLVJI12fGGwdDDzeJJicW5iaX6gbJVu[W5iUFLNJINmdGy\|LDDFR\|kxRTBwMElOwG0>	NIe3U3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkO4N\|AyPCd-MUKzPFMxOTR:L3G+
PBMC	MUDGeY5kfGmxbjDhd5NigQ>?			M4LSSmFkfGm4aYT5JIFo[Wmwc4SgUIFucX[3ZHnu[U1z\XOrc4ThcpQhfmm{dYOgLGhKXi1zWGjCVnUqKGmwIHj1cYFvKFCETTDj[YxteyxiZYjwdoV{e2WmIHHzJGVEPTBuIFXDOVA:OC5yM{ZOwG0>	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh3Mke1OUc,OTJ6NUK3OVU9N2F-
PBMC	M2nXcGZ2dmO2aX;uJIF{e2G7			Mn7GTY4hfmm2cn:gZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcohq[mm2IITo[UBJUVZvMTDMRVEhemWybHnjZZRqd25ib36gVGJOS3NiY3XscEApeGW{aYDo[ZJidCCkbH;v[EBud26xboXjcIVieiClZXzsd{ktKEWFNUC9NE4xOc7:TR?=	NWHlco9nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4OVI6PDNpPkGyPFUzQTR\|PD;hQi=>
PBMC	NVz3V25iTnWwY4Tpc44h[XO\|YYm=			MYHF[oZm[3SrdnWgZ49v[2WwdILheIlwdiC2bzDpcohq[mm2IFjJWk0yKEyDSTDjfZRweGG2aHnjbZR6KGmwIGDCUWMh[2WubIOge4F{KGSndHXycYlv\WRiaX6geol1em9uIFXDOVA:OC5yMUG2{txO	NH;FVWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEm3NVg6QCd-MUS5O\|E5QTh:L3G+
HepG2.2.15	Mon5SpVv[3Srb36gZZN{[Xl?			Mn7FSYZn\WO2aY\lJINwdmOnboTyZZRqd25idH:gbY5pcWKrdDDo[ZBifGm2aYOgRkB3cXK3czDjfZRweGG2aHnjbZR6KGmwIFjldGczNjJwMUWgZ4VtdHNid3HzJIRmfGW{bXnu[YQhcW5idnn0do8tKEWFNUC9NE4z\|ryP	NX3ZSXZuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5O\|E5QThpPkG0PVcyQDl6PD;hQi=>
MT-4	NXWxRVBqTnWwY4Tpc44h[XO\|YYm=			NVLIW4djTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36geI8hcW6qaXLpeEBJUVZvMTDJTWlDKGO7dH;wZZRpcWOrdImgbY4hVVRvNDDj[YxteyC5YYOg[IV1\XKvaX7l[EBqdiC4aYTyc{whTUN3ME2wMlXPxE1?	M4XTNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2OUexPFk5Lz5zNEm3NVg6QDxxYU6=
PBMC	MUDBcpRqfmm{YXygZZN{[Xl?			MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDD3bYxlKHS7cHWgTGlXKH[rcoXzLJh5SlKXKTDpckBJfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJEhRSk1rIHPlcIx{NCCHQ{mwQVAvODkQvF2=	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB{N{i1OEc,OTVyMke4OVQ9N2F-
PBMC	NVfIb2JtTnWwY4Tpc44h[XO\|YYm=			M1LBSGVn\mWldHn2[UBkd26lZX70doF1cW:wIHHnZYlve3RiV3ns[EBVgXCnIFjJWk0yKH[rcoXzJIlvKGi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIh[2WubIOsJGVEPTB;MD6wOFHPxE1?	MkewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVzOEmwN\|YoRjF3MUi5NFM3RC:jPh?=
CEM-SS	NX7BeFRPSW62aY\pdoFtKGG\|c3H5		NWftTWxHPiCmYYnz	M1LJUGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiM1KgbY5n\WO2ZXSgbY4hcHWvYX6gR2VONVOVIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB4IHThfZMh[nliTWTTJIF{e2G7LDDFSFUxRTBwM{dOwG0>	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTJzN{K4NUc,OTV{MUeyPFE9N2F-
HOG.R5	NVLmTWh2SW62aY\pdoFtKGG\|c3H5		NEfMSWg1KGSjeYO=	M{LEc2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiM1KgbY5n\WO2ZXSgbY4hcHWvYX6gTG9INlJ3IHPlcIx{KGGodHXyJFQh\GG7czygTWM2OD1zLkNOwG0>	NWjQeYk1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWyNVczQDFpPkG1NlE4OjhzPD;hQi=>
2.2.15	MVzGeY5kfGmxbjDhd5NigQ>?			MWHJcohq[mm2aX;uJI9nKEiEVjDy[ZBtcWOjdHnvckBqdiB{LkKuNVUh[2WubIOgZpkhTE6DIHj5ZpJq\Gm8YYTpc44h[XO\|YYmsJGVEPTB;MD6wNu69VQ>?	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZzNUW0OUc,OTV4MUW1OFU9N2F-
2.2.15	MYXGeY5kfGmxbjDhd5NigQ>?			NH20[pRG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JIhmeGG2aYTpd{BDKH[rcoXzJJJmeGyrY3H0bY9vKGmwIEKuNk4yPSClZXzsd{BqdiCGTlGgbJljemmmaYrheIlwdiCjc4PhfUwhTUN3ME2wMlA2\|ryP	NXnkW4d1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2N\|QxODNpPkG1OlM1ODB\|PD;hQi=>
PBMC	NFrFPJNHfW6ldHnvckBie3OjeR?=			NEHOS45KdiC4aYTyc{Bm\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IFzhcYl3fWSrbnWgdoV{cXO2YX70JJdqdGRidInw[UBJUVZvMTDpckBpfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJINmdGy\|LDDFR\|UxRTBwMEK3{txO	M2jnUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3OUG2OFI2Lz5zNUmxOlQzPTxxYU6=
PBMC	M3X3bGZ2dmO2aX;uJIF{e2G7			NFjD[pJKdiC4aYTyc{Bm\m[nY4TpeoUh[2:wY3XueJJifGmxbjDh[4FqdnO2IFzhcYl3fWSrbnWgdoV{cXO2YX70JJdqdGRidInw[UBJUVZvMTDpckBpfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJINmdGy\|LDDFR\|kxRTBwMkZOwG0>	NIXsW3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUmxOlQzPSd-MUW5NVY1OjV:L3G+
2.2.15	NUPreVUzTnWwY4Tpc44h[XO\|YYm=			NXXK[olvTW[oZXP0bZZmKGOxbnPlcpRz[XSrb37zJIF1KHeqaXPoJFIu\m:uZDDk[ZBz\XO\|aX;uJI9nKGW6dILhZ4VtdHWuYYKgeolzcW:wIFTORUApUEKYKTD3ZZMhd2K\|ZYL2[YQhcW5iMj6yMlE2KEOnbHzzMEBGSzVyPUCuNFbPxE1?	M2nlXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MEOzNlg{Lz5zNkCzN\|I5OzxxYU6=
2.2.15	NEHzZ4dHfW6ldHnvckBie3OjeR?=			Moe2SYZn\WO2aY\lJINwdmOnboTyZZRqd26\|IHH0JJdpcWOqIEKt[o9t\CCmZYDy[ZN{cW:wIH;mJIV5fHKjY3XscJVt[XJidnnybY9vKESQQTCoTGJXMSC5YYOgc4J{\XK4ZXSgbY4hOi5{LkG1JGNmdGy\|LDDFR\|kxRTBwMUhOwG0>	M4TleFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MEOzNlg{Lz5zNkCzN\|I5OzxxYU6=
2.2.15	Mn\DSpVv[3Srb36gZZN{[Xl?			M{PVd2Vn\mWldHn2[UBkd26lZX70doF1cW:wczDheEB4cGmlaDCxNE1nd2ymIHTldJJme3Orb36gc4YhcW62cnHj[YxtfWyjcjDpcpRmem2nZHnheIV{KG:oIFjCWkBFVkFid3HzJI9je2W{dnXkJIlvKDJwMj6xOUBE\WyuczygSWM2OD1yLkKz{txO	NYPzVmdURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[wN\|MzQDNpPkG2NFM{Ojh\|PD;hQi=>
2.2.15	NFjHVoZHfW6ldHnvckBie3OjeR?=			NWLtVWtTTW[oZXP0bZZmKGOxbnPlcpRz[XSrb37zJIF1KHeqaXPoJFExNW[xbHSg[IVxemW\|c3nvckBw\iCrboTyZYNmdGy3bHHyJIlvfGW{bXXkbYF1\XNib3[gTGJXKESQQTD3ZZMhd2K\|ZYL2[YQhcW5iMj6yMlE2KEOnbHzzMEBGSzlyPUCuOlnPxE1?	NWnOU2dNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[wN\|MzQDNpPkG2NFM{Ojh\|PD;hQi=>
2.2.15	M3nTfGZ2dmO2aX;uJIF{e2G7			NUL1fZozUW6qaXLpeIlwdiCxZjDzfY51cGW\|aYOgc4Yh\Xi2cnHj[YxtfWyjcjD2bZJqd25iRF7BJJJmdGWjc3WgbY4h[3WudIXy[YQhcHWvYX6gbIVx[XSxYnzhd5RwdWFiMj6yMlE2KGOnbHzzMEBGSzVyPUCuNFQ5\|ryP	NH3ROIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkKxN\|cyOyd-MU[yNVM4OTN:L3G+
2.2.15	NUTOdGJbTnWwY4Tpc44h[XO\|YYm=			NHLqT5RKdmirYnn0bY9vKG:oIIP5cpRp\XOrczDv[kBmgHS{YXPlcIx2dGG{II\pdolwdiCGTlGgdoVt\WG\|ZTDpckBkfWy2dYLl[EBpfW2jbjDo[ZBifG:kbHHzeI9u[SB{LkKuNVUh[2WubIOsJGVEQTB;MD6xOVHPxE1?	MknNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ{MUO3NVMoRjF4MkGzO\|E{RC:jPh?=
2.2.15	NWjTcIZnTnWwY4Tpc44h[XO\|YYm=			M4THbmlvcGmkaYTpc44hd2Zic4nueIhme2m\|IH;mJIlvfHKjY3XscJVt[XJiSFLWJGRPSSC{ZYDsbYNifGm4ZTDpcpRmem2nZHnheIV{KGmwIHP1cJR2emWmIHj1cYFvKGincHH0c4Jt[XO2b33hJFIvOi5zNTDj[YxteyxiRVO1NF0xNjJ3Md88US=>	MlPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ{MUO3NVMoRjF4MkGzO\|E{RC:jPh?=
2.2.15	MVzGeY5kfGmxbjDhd5NigQ>?			MXjJcohq[mm2aX;uJI9nKHO7boTo[ZNqeyCxZjDpcpRz[WOnbHz1cIFzKEiEVjDEUmEhemWybHnjZZRqfmViaX70[ZJu\WSrYYTld{BqdiCldXz0eZJm\CCqdX3hckBp\XCjdH;icIF{fG:vYTCyMlIvOTViY3XscJMtKEWFOUC9NE43PDkQvF2=	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjJzM{exN{c,OTZ{MUO3NVM9N2F-
2.2.15	M1m2N2Z2dmO2aX;uJIF{e2G7			MniwTY5pcWKrdHnvckBw\iC5aXzkJJR6eGViSFLWJJRz[W6\|ZnXjeIVlKGmwIHj1cYFvKGincHH0c4Jt[XO2b33hJFIvOi5zNTDj[YxteyxiRVO1NF0zNjIQvF2=	MkjnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzPVMoRjF4NUO5N\|k{RC:jPh?=
hepatoma 2.2.15	MXPBcpRqfmm{YXygZZN{[Xl?			MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDD3bYxlKHS7cHWgTGJXKGmwIHj1cYFvKGincHH0c41iKDJwMj6xOUBk\WyuczygSWM2OD1{LkJOwG0>	NWfjNZJZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3OVkyOTJpPkG2O\|U6OTF{PD;hQi=>
2.2.15	MmTnSpVv[3Srb36gZZN{[Xl?			NFizOXBKdmirYnn0bY9vKG:oIFjCWkBz\XCuaXPheIlwdiCrbjCyMlIvOTViY3XscJMh[nliRF7BJIh6[nKrZHn6ZZRqd25iYYPzZZktKEWFNUC9NE4xOs7:TR?=	MlTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyMES3NlYoRjF5MEC0O\|I3RC:jPh?=
MDCK2	NIXle\|NHfW6ldHnvckBie3OjeR?=	M2PDTVExKHWP		NX\PS5R2UW6qaXLpeIlwdiCxZjDoeY1idiCPUmCyJIV5eHKnc4Pl[EBqdiCPRFPLNkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJGNOTiCobIXvdoV{[2WwY3WgZZQhOTBidV2gZpkhS02IRFGgZZN{[Xl?	M2DkOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUeyN\|EyLz5zN{G3NlMyOTxxYU6=
MDCK2	NVK2e4JPTnWwY4Tpc44h[XO\|YYm=	NX7VRoRZOTBidV2=		NHr5bopKdmirYnn0bY9vKG:oIHj1cYFvKE2UUEOg[ZhxemW\|c3XkJIlvKE2GQ1uyJINmdGy\|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgR21HKG[udX;y[ZNk\W6lZTDheEAyOCC3TTDifUBEVU[GQTDhd5NigQ>?	M{\ob\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUeyN\|EyLz5zN{G3NlMyOTxxYU6=
MDCK2	M{XxVWZ2dmO2aX;uJIF{e2G7	NWjhWZJVOTBidV2=		MXTJcohq[mm2aX;uJI9nKGi3bXHuJG1TWDFiZYjwdoV{e2WmIHnuJG1FS0t{IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnuZ5Jm[XOnIHnuJIlvfHKjY3XscJVt[XJiQ13GJIZtfW:{ZYPj[Y5k\SCjdDCxNEB2VSCkeTDDUWZFSSCjc4PhfS=>	NXfWOIl4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexO\|I{OTFpPkG3NVczOzFzPD;hQi=>
Huh7	MlLxSpVv[3Srb36gZZN{[Xl?			M3foRmlvcGmkaYTpc44hd2Zid3ns[EB1gXCnIFjCWkBz\XCuaXPheIlwdiCrbjDIeYg4KGOnbHzzMEBGSzVyPUJOwG0>	NF;WVow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O3NVgzPyd-MUezO\|E5Ojd:L3G+
PBMC	M3nRWmFvfGm4aYLhcEBie3OjeR?=			MWTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYyKEyDSTDpckBpfW2jbjDQRm0h[2WubIOsJGVEPTB;MD6wNlbPxE1?	M3Xnb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NECzPVk3Lz5zN{SwN\|k6PjxxYU6=
PBMC	NEPjXGdCdnSrdnnyZYwh[XO\|YYm=			MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYyKEyDSTDpckBpfW2jbjDQRm0h[2WubIOsJGVEQTB;MD6xNu69VQ>?	M2O3cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NECzPVk3Lz5zN{SwN\|k6PjxxYU6=
HepG2.2.15	MlXCRY51cX[rcnHsJIF{e2G7			NF\3fXBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX6gTIVxTzJwMj6xOUBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCneITyZYNmdGy3bHHyJJZqemGuIFTORUBt\X[nbDDifUBTXC2SQ2KsJGVEPTB;MD6x{txO	NX7EW3NoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NFQxODZpPkG3OFA1ODB4PD;hQi=>
Huh7	NX\EUGI4SW62aY\pdoFtKGG\|c3H5		MWm1JIRigXN?	NHzWdlNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiZ3Xuc5R6eGViRDD3bZRpKHKndnXyd4UhfHKjboPjdolxfGG\|ZTDMPFBKKG23dHH0bY9vKGmwIHj1cYFvKEi3aEegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA2KGSjeYOsJGVEPTB;MD6wN:69VQ>?	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR\|OEC0O{c,OTd2M{iwOFc9N2F-
Huh7	MkXKRY51cX[rcnHsJIF{e2G7		MkfCOUBl[Xm\|	Mnj6RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJmSWdvZHXmbYNq\W62IFjCWkBo\W6xdInw[UBFKHerdHigdJJm[2:{ZTDHNVg6PkFibYX0ZZRqd25iYX7kJJJmfmW{c3WgeJJidnOlcnnweIF{\SCOOEDJJI12fGG2aX;uJIlvKGi3bXHuJGh2cDdiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjC1JIRigXNuIFXDOVA:OC5yM988US=>	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR\|OEC0O{c,OTd2M{iwOFc9N2F-
Huh7	NWTpUHMySW62aY\pdoFtKGG\|c3H5		NF\lbXo2KGSjeYO=	NX6z[nd{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHflco91gXCnIFSgbY4hcHWvYX6gTJVpPyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEWg[IF6eyxiRVO1NF0xNjRzzszN	NIrQblg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SzPFA1Pyd-MUe0N\|gxPDd:L3G+
Huh7	MkWzRY51cX[rcnHsJIF{e2G7		MYO1JIRigXN?	NVLEb\|VvSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKnQXet[IVncWOrZX70JGhDXiCpZX7veJlx\SCGIIfpeIgheHKnY3;y[UBIOTh7NlGgcZV1[XSrb36gbY4hcHWvYX6gTJVpPyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEWg[IF6eyxiRVO1NF0xNjR4zszN	M{ezR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEO4NFQ4Lz5zN{SzPFA1PzxxYU6=
HepG2(2.2.15)	M2XkPWFvfGm4aYLhcEBie3OjeR?=			MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDIRnYhcW5iYYn3JJdqdGRidInw[UBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yhfmm{YXygSG5CKHKncHzpZ4F1cW:wLDDJR\|UxRTBwMEZOwG0>	NGX3O4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S4PFgyPyd-MUe0PFg5OTd:L3G+
HepG2(2.2.15)	NWfkXnBwTnWwY4Tpc44h[XO\|YYm=			MleyTY5pcWKrdHnvckBw\iCKQm[gdJJwdW:2ZYKgbY4hcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO\|YYmsJGlEPTB;MD6wPO69VQ>?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR6OEixO{c,OTd2OEi4NVc9N2F-
HepW10	MlntRY51cX[rcnHsJIF{e2G7			MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDIRnYhcW5iYXTybYFugWOrbj3y[ZNqe3SjboSge4lt\CC2eYDlJGhmeFdzMDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJGRPSSC{ZYDsbYNifGmxbjygTWM2OD1yLkJOwG0>	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR6OEixO{c,OTd2OEi4NVc9N2F-
HBV-Met	MlrJRY51cX[rcnHsJIF{e2G7			NXiwZXVzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnuJI1wfXOnIHH5e{B4cWymIIT5dIUhUEKYLV3leEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKESQQTDy[ZBtcWOjdHnvckwhUUN3ME2wMlLPxE1?	NIrXPIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S4PFgyPyd-MUe0PFg5OTd:L3G+
HepG2.2.15	NFLxS2hHfW6ldHnvckBie3OjeR?=		NIr0[FQ5KGSjeYO=	NHnZNmNKdmirYnn0bY9vKG:oIHP5eI9xdGG\|bXnjJGhDXiCGTlGgd5lvfGinc3nzJIlvKEincFeyMlIvOTViY3XscJMh[W[2ZYKgPEBl[Xm\|LDDJR\|UxRTBwM{lOwG0>	NWjVcGNuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVk5QDlpPkG3OFk6QDh7PD;hQi=>
PBMC	NHfteVdHfW6ldHnvckBie3OjeR?=	MlrtN\|AxKG2p	M4[zR\|ch\GG7cx?=	MmfHR41igCCrbjDITXYucW6oZXP0[YQhcHWvYX6gZZN{\XO\|ZXSgZZMhVGGvaY\1[Ilv\SCvb37vdIhwe3CqYYTlJIxmfmWuIHnuJHBDVUNiYYSgN\|AxKG2pIGHEJIZweiB5IHThfZMhdWWjc4Xy[YQheGW{IEGwK\|Yh[2WubIOgbY4heHKnc3XuZ4Uhd2Ziennkc5Z2\GmwZTygR41igD1yLkCwNFAxODkQvF2=	MkfoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkSzNlgoRjF5Nk[0N\|I5RC:jPh?=
PBMC	M{C0eGZ2dmO2aX;uJIF{e2G7	MnrEN\|AxKG2p	M13vW\|ch\GG7cx?=	MkL0R41igCCrbjDITXYucW6oZXP0[YQhcHWvYX6gZZN{\XO\|ZXSgZZMhVGGvaY\1[Ilv\SCmaYDoc5NxcGG2ZTDs[ZZmdCCrbjDQRm1EKGG2IEOwNEBu\yCTRDDmc5IhPyCmYYnzJI1m[XO3cnXkJJBmeiBzMDe2JINmdGy\|IHnuJJBz\XOnbnPlJI9nKHqrZH;2eYRqdmVuIFPtZZg:OC5yMECwNFQ1\|ryP	NUSyR3ZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2OlQ{OjhpPkG3OlY1OzJ6PD;hQi=>
PBMC	MoTmSpVv[3Srb36gZZN{[Xl?	M2jI[lMxOCCvZx?=	NHPDTmE4KGSjeYO=	MYnDcYF5KGmwIFjJWk1qdm[nY4Tl[EBpfW2jbjDhd5Nme3OnZDDhd{BN[W2rdoXkbY5mKHS{aYDoc5NxcGG2ZTDs[ZZmdCCrbjDQRm1EKGG2IEOwNEBu\yCTRDDmc5IhPyCmYYnzJI1m[XO3cnXkJJBmeiBzMDe2JINmdGy\|IHnuJJBz\XOnbnPlJI9nKHqrZH;2eYRqdmVuIFPtZZg:OC5yMECwNFQ5\|ryP	MoXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkSzNlgoRjF5Nk[0N\|I5RC:jPh?=
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MT2	MXvBcpRqfmm{YXygZZN{[Xl?		MoLjOUBl[Xm\|	MULBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDCwMlAzKE2RSTD3bYxlKHS7cHWgTGlXOSCQTEStN{Bqdm[nY4Tl[EBqdiB{IHjyMZBz\XS{ZXH0[YQhcHWvYX6gUXQzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEWg[IF6eyCkeTDSWEBUWEFuIFXDOVA:OS57OEZOwG0>	MkS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh\|MU[1NlEoRjF6M{G2OVIyRC:jPh?=
MT2	MX;BcpRqfmm{YXygZZN{[Xl?		NX3WcVB4PSCmYYnz	MnzXRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgNE4xOiCPT1mge4lt\CC2eYDlJGhKXjFiTly0MVMhcW6oZXP0[YQhcW5iMjDodk1xemW2cnXheIVlKGi3bXHuJG1VOiClZXzsd{Bu\WG\|dYLl[EBi\nSncjC1JIRigXNiYomgUXRUKGG\|c3H5MEBGSzVyPUKuOFQ2\|ryP	NIX2b2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOxOlUzOSd-MUizNVY2OjF:L3G+
MT2	NYnUPGU5SW62aY\pdoFtKGG\|c3H5		Mo\YOUBl[Xm\|	MX;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDCwMlA2KE2RSTD3bYxlKHS7cHWgTGlXOSCQTEStN{Bqdm[nY4Tl[EBqdiB{IHjyMZBz\XS{ZXH0[YQhcHWvYX6gUXQzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEWg[IF6eyCkeTDSWEBUWEFuIFXDOVA:Oi52N988US=>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzNkWyNUc,OTh\|MU[1NlE9N2F-
MT2	NW[3UlYzSW62aY\pdoFtKGG\|c3H5		MUe1JIRigXN?	M17CRWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFAvODViTV;JJJdqdGRidInw[UBJUVZzIF7MOE0{KGmwZnXjeIVlKGmwIEKgbJIueHKndILlZZRm\CCqdX3hckBOXDJiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgOUBl[Xm\|IHL5JG1VWyCjc4PhfUwhTUN3ME2zMlI1P87:TR?=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzNkWyNUc,OTh\|MU[1NlE9N2F-
HepG2(2.2.15)	M2\6SWFvfGm4aYLhcEBie3OjeR?=		M4fXTFI1KGi{cx?=	MWrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDIRnYhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDlfJRz[WOnbHz1cIFzKEiEVjD2bZJqd25iRF7BJIxmfmWuIHHmeIVzKDJ2IHjyd{whTUN3ME2wMlA1QM7:TR?=	NYfoOJpWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwO\|I3QTRpPkG5NFczPjl2PD;hQi=>
HepG2(2.2.15)	NV65O3I4SW62aY\pdoFtKGG\|c3H5		NWfNOYE3OjRiaILz	MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDIRnYhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDy[ZBtcWOjdHnvckBqdnSncn3l[IlifGW\|IHHmeIVzKDJ2IHjyd{whTUN3ME2wMlE2\|ryP	M2XN[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7	NWDFRpRMSW62aY\pdoFtKGG\|c3H5		Mmi2OEBl[Xm\|	NESwSXhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBt[W2rdoXkbY5mNXKnc3nzeIFvfCC5aXzkJJR6eGViSFLWJIlvKGi3bXHuJGh2cDdiY3XscJMh[W[2ZYKgOEBl[Xm\|IHL5JIlvfHKjY3XscJVt[XJiSFLWJGRPSSC{ZYDsbYNifGmxbjDhd5NigSxiRVO1NF0xNjMQvF2=	NIrQN2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO\|I3QTR:L3G+
Huh7	NFXWO3NCdnSrdnnyZYwh[XO\|YYm=		NWLBUYxiPCCmYYnz	NWq0bmY{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhdGGvaY\1[Ilv\S2{ZYPpd5RidnRiSFLWJJJmfmW{c3WgeJJidnOlcnnweIF{\SB{M{\UJI12fGGwdDDpckBpfW2jbjDIeYg4KGOnbHzzJIFnfGW{IESg[IF6eyCkeTDpcpRz[WOnbHz1cIFzKEiEVjDEUmEhemWybHnjZZRqd25iYYPzZZktKEWFNUC9NE4{\|ryP	M2G1S\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7	MU\BcpRqfmm{YXygZZN{[Xl?		MnzFOEBl[Xm\|	MYfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDh[IVnd3[rcj3y[ZNqe3SjboSge4lt\CC2eYDlJGhDXiCrbjDoeY1idiCKdXi3JINmdGy\|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO\|YYmsJGVEPTB;MT6z{txO	NHfxfWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO\|I3QTR:L3G+
Huh7	NF3wUnFCdnSrdnnyZYwh[XO\|YYm=		MUG0JIRigXN?	MlPxRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRm\m:4aYKtdoV{cXO2YX70JGhDXiC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUVIxPFZibYX0ZY51KGmwIHj1cYFvKEi3aEegZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KGmwdILhZ4VtdHWuYYKgTGJXKESQQTDy[ZBtcWOjdHnvckBie3OjeTygSWM2OD1zLkZOwG0>	MnnXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
Huh7	MmXERY51cX[rcnHsJIF{e2G7		Mo\5OEBl[Xm\|	MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDh[IVnd3[rcj3y[ZNqe3SjboSgTGJXKHKndnXyd4UhfHKjboPjdolxfGG\|ZTDMNVgxVSCvdYThcpQhcW5iaIXtZY4hUHWqNzDj[YxteyCjZoTldkA1KGSjeYOgZpkhcW62cnHj[YxtfWyjcjDIRnYhTE6DIILldIxq[2G2aX;uJIF{e2G7LDDFR\|UxRTFwNt88US=>	NYn2UndTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwO\|I3QTRpPkG5NFczPjl2PD;hQi=>
Huh7	NETCcodCdnSrdnnyZYwh[XO\|YYm=		MVu0JIRigXN?	M3TncmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl\W[xdnnyMZJme2m\|dHHueEBJSlZicnX2[ZJ{\SC2cnHud4NzcXC2YYPlJGxON3KndnXyd4UhfHKjboPjdolxfGG\|ZTDNWkBld3WkbHWgcZV1[W62IHnuJIh2dWGwIFj1bFch[2WubIOgZYZ1\XJiNDDkZZl{KGK7IHnueJJi[2WubIXsZZIhUEKYIFTORUBz\XCuaXPheIlwdiCjc4PhfUwhTUN3ME2xMlbPxE1?	MmnOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
Huh7	NU[yR\|NTSW62aY\pdoFtKGG\|c3H5		MX20JIRigXN?	MmTrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRm\m:4aYKtdoV{cXO2YX70JGhDXiC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUVIxPElibYX0ZY51KGmwIHj1cYFvKEi3aEegZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KGmwdILhZ4VtdHWuYYKgTGJXKESQQTDy[ZBtcWOjdHnvckBie3OjeTygSWM2OD1zLklOwG0>	Mn3IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
Huh7	MXnBcpRqfmm{YXygZZN{[Xl?		NUHKSoJzPCCmYYnz	M1T2cGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl\W[xdnnyMZJme2m\|dHHueEBJSlZicnX2[ZJ{\SC2cnHud4NzcXC2YYPlJFI{PlRibYX0ZY51KGmwIHj1cYFvKEi3aEegZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KGmwdILhZ4VtdHWuYYKgTGJXKESQQTDy[ZBtcWOjdHnvckBie3OjeTygSWM2OD15LkhOwG0>	NHzaW\|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO\|I3QTR:L3G+
Huh7	MXPBcpRqfmm{YXygZZN{[Xl?		MUG0JIRigXN?	NHrPS4hCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBt[W2rdoXkbY5mNXKnc3nzeIFvfCCKQm[gdoV3\XK\|ZTD0doFve2O{aYD0ZZNmKExzOEDNJI12fGGwdDDpckBpfW2jbjDIeYg4KGOnbHzzJIFnfGW{IESg[IF6eyCkeTDpcpRz[WOnbHz1cIFzKEiEVjDEUmEhemWybHnjZZRqd25iYYPzZZktKEWFNUC9NVDPxE1?	NF;3[289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO\|I3QTR:L3G+
HuH7	MnfSRY51cX[rcnHsJIF{e2G7		Mn7xNlQhcHK\|	NHO3O\|JCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymIIT5dIUhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFj1TFch[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5idnnyZYwhfHKjboPp[Y51KHS{YX7z[oVkfGmxbjDh[pRmeiB{NDDodpMtKEWFNUC9NE4z\|ryP	NEfDUFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7	NUXBOGV2SW62aY\pdoFtKGG\|c3H5		NGG4dJUzPCCqcoO=	NWjrelY3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHjhdoJwemmwZzDSUmEheG:ueX3ldoF{\SCQMkO2WEBufXSjboSg[4Vv\SCrbn\lZ5Rm\CCrbjDoeY1idiCKdVi3JINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKH[rcnHsJJRz[W6\|aXXueEB1emGwc3\lZ5Rqd25iYX\0[ZIhOjRiaILzMEBGSzVyPUCuN:69VQ>?	NGfKTIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7	M3jqR2FvfGm4aYLhcEBie3OjeR?=		MW[yOEBpenN?	M2fVb2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCqYYLic5JqdmdiUl7BJJBwdHmvZYLhd4UhVjJ\|NmSgcZV1[W62IHflcoUhcW6oZXP0[YQhcW5iaIXtZY4hUHWKNzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckB3cXKjbDD0doFve2mnboSgeJJidnOoZXP0bY9vKGGodHXyJFI1KGi{czygSWM6OD1zLkZOwG0>	NF3FeFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7	NIHCbIpCdnSrdnnyZYwh[XO\|YYm=		NHfsR5czPCCqcoO=	MYXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDD3bYxlKHS7cHWgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEi3SEegZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hfmm{YXygeJJidnOrZX70JJRz[W6\|ZnXjeIlwdiCjZoTldkAzPCCqcoOsJGVEQTB;M988US=>	NFXXV449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7	NVX4V2pvSW62aY\pdoFtKGG\|c3H5		MnPINlQhcHK\|	M{HURmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCqYYLic5JqdmdiUl7BJJBwdHmvZYLhd4UhVDF6MF2gcZV1[W62IHflcoUhcW6oZXP0[YQhcW5iaIXtZY4hUHWKNzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckB3cXKjbDD0doFve2mnboSgeJJidnOoZXP0bY9vKGGodHXyJFI1KGi{czygSWM2OD1zNt88US=>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7OE[0PEc,OTl\|OUi2OFg9N2F-
HuH7	MULBcpRqfmm{YXygZZN{[Xl?		Mm\ZNlQhcHK\|	Mn;xRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGijcnLvdolv\yCUTlGgdI9tgW2ncnHz[UBNOThyTTDteZRidnRiZ3Xu[UBqdm[nY4Tl[EBqdiCqdX3hckBJfUh5IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJJZqemGuIITyZY5{cWWwdDD0doFve2[nY4Tpc44h[W[2ZYKgNlQhcHK\|LDDFR\|kxRTRzzszN	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7OE[0PEc,OTl\|OUi2OFg9N2F-
MT2	NYfaUmR7SW62aY\pdoFtKGG\|c3H5			M2S4bWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiaX7m[YN1\WRiaX6gbJVu[W5iTWSyJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25uIFnDOVA:OC54zszN	MlzhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3OU[4PFUoRjF7NUm2PFg2RC:jPh?=
HeLa P4/R5	NXTrdm5ySW62aY\pdoFtKGG\|c3H5			M1jmTWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiaX7m[YN1\WRiaX6gbJVu[W5iSHXMZUBRPC:UNTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vNCCLQ{WwQVAvPzkQvF2=	Mn;IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3OU[4PFUoRjF7NUm2PFg2RC:jPh?=
TZM-bl	NV\CZ5BOSW62aY\pdoFtKGG\|c3H5		NYXpbHR1PzJiaILz	NUWxXZpYSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDwUmw1NTNiaHHyZo9zcW6pIGLleoVze2VidILhcpNkemmydHHz[UBROTF7UzDteZRidnRiZ3Xu[UBqdm[nY4Tl[EBqdiCWWl2tZowh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHz1Z4ln\XKjc3WgZZN{[XluIFXDOVA:OC52N988US=>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTdyNEGzNUc,OTl5MESxN\|E9N2F-
TZM-bl	MUTBcpRqfmm{YXygZZN{[Xl?			NXy2XmdPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZD30fZBmKEiLVkGgdG5NPC1\|IHnu[oVkfGWmIHnuJHRbVS2kbDDj[YxteyCkeTDseYNq\mW{YYPlJIF{e2G7LDDFR\|UxRTBwNkZOwG0>	NGXkNG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUewOFE{OSd-MUm3NFQyOzF:L3G+
TZM-bl	NWHVSlRFSW62aY\pdoFtKGG\|c3H5		MnT5O\|IhcHK\|	MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYyKHCQTEStN{Bp[XKkb4LpcochWmW4ZYLz[UB1emGwc3PybZB1[XOnIGSxOlVCKG23dHHueEBo\W6nIHnu[oVkfGWmIHnuJHRbVS2kbDDj[YxteyCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhTUN3ME2xMlA5\|ryP	MlXIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5MESxN\|EoRjF7N{C0NVMyRC:jPh?=
TZM-bl	MX7BcpRqfmm{YXygZZN{[Xl?		MX:3NkBpenN?	MlztRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCyTly0MVMhcGG{Yn;ybY5oKFKndnXyd4UhfHKjboPjdolxfGG\|ZTDQNVE6Wy:WMU[1RUBufXSjboSg[4Vv\SCrbn\lZ5Rm\CCrbjDUXm0u[mxiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIx2[2moZYLhd4Uh[XO\|YYmsJGVEPTB;Mj6x{txO	Mn:5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5MESxN\|EoRjF7N{C0NVMyRC:jPh?=
HepG2.2.15	MojCRY51cX[rcnHsJIF{e2G7			MXPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDIRnYhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KuNk4yPSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIFTORUBz\XCuaXPheIlwdixiSVO1NF0xNjJ{zszN	NVvqO5ZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4PVc{PjNpPkG5PFk4OzZ\|PD;hQi=>
1.3ES2	MV;BcpRqfmm{YXygZZN{[Xl?		M4T3eFYh\GG7cx?=	NIPMZoRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XCjdHn0bZMhSiC4aYL1d{BigXdiaX6gbJVu[W5iMT6zSXMzKGOnbHzzJJN1[WKueTD0doFve2[nY4Tl[EB4cXSqIEGuN{Bnd2ymIIfpcIQhfHmyZTDIRnYh[Xm5IIP0doFqdiCpZX7vcYUh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKG:oII\pdoFtKESQQTDs[ZZmdCCjZoTldkA3KGSjeYOgZpkhWlRvUFPS	NHXN[2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC2NVE2QCd-MkCwOlEyPTh:L3G+
HepG2.2.15	M{PrW2FvfGm4aYLhcEBie3OjeR?=		M1XPUFkh\GG7cx?=	NUDqZpdHSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiEVjDpcoZm[3SnZDDpckBJ\XCJMj6yMlE2KGOnbHzzJIF{e2W\|c3XkJIF{KG63Y3zlbYMh[WOrZDDhcoQheHKxdHXpckBt\X[nbIOg[I9{\WRiZHHpcJkh\m:{IEmg[IF6eyCjbnSgcYVie3W{ZXSgNlQhcHK\|IHHmeIVzKGyjc4SgeJJm[XSvZX70JIJ6KFOxdYTo[ZJvKGKub4SgbJljemmmaYrheIlwdixiRVO1NF0xNjMQvF2=	NIj6eoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGxO\|k{OCd-MkCxNVc6OzB:L3G+
HepG2.2.15	NEnuVI5CdnSrdnnyZYwh[XO\|YYm=		NGjTU3k6KGSjeYO=	MkDSRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgRWRXNXKnc3nzeIFvfCCKQm[gUlI{PlRibYX0ZZRqd25iaX7m[YN1\WRiaX6gTIVxTzJwMj6xOUBk\WyuczDhd5Nme3OnZDDhd{BvfWOuZXnjJIFkcWRiYX7kJJBzd3SnaX6gcIV3\Wy\|IHTvd4VlKGSjaXz5JIZweiB7IHThfZMh[W6mIH3lZZN2emWmIEK0JIhzeyCjZoTldkBt[XO2IITy[YF1dWWwdDDifUBUd3W2aHXyckBjdG:2IHj5ZpJq\Gm8YYTpc44tKEWFNUC9NE4z\|ryP	M4jh[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUG3PVMxLz5{MEGxO\|k{ODxxYU6=
HepG2.2.15	NXnpS2x6SW62aY\pdoFtKGG\|c3H5		M3LUPFkh\GG7cx?=	NXnRRlN6SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiEVjDpcoZm[3SnZDDpckBJ\XCJMj6yMlE2KGOnbHzzJIF{e2W\|c3XkJIF{KG63Y3zlbYMh[WOrZDDhcoQheHKxdHXpckBt\X[nbIOg[I9{\WRiZHHpcJkh\m:{IEmg[IF6eyCjbnSgcYVie3W{ZXSgNlQhcHK\|IHHmeIVzKGyjc4SgeJJm[XSvZX70JIJ6KFOxdYTo[ZJvKGKub4SgbJljemmmaYrheIlwdixiRVO5NF0xNjgQvF2=	NGfSZYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGxO\|k{OCd-MkCxNVc6OzB:L3G+
HepG2.2.15	NVLOc\|ZQSW62aY\pdoFtKGG\|c3H5		NY\jbI1LQSCmYYnz	Moe3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgRWRXNXKnc3nzeIFvfCCKQm[gUlI{PlRibYX0ZZRqd25iaX7m[YN1\WRiaX6gTIVxTzJwMj6xOUBk\WyuczDhd5Nme3OnZDDhd{BvfWOuZXnjJIFkcWRiYX7kJJBzd3SnaX6gcIV3\Wy\|IHTvd4VlKGSjaXz5JIZweiB7IHThfZMh[W6mIH3lZZN2emWmIEK0JIhzeyCjZoTldkBt[XO2IITy[YF1dWWwdDDifUBUd3W2aHXyckBjdG:2IHj5ZpJq\Gm8YYTpc44tKEWFOUC9NE45\|ryP	MnPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMUe5N\|AoRjJyMUG3PVMxRC:jPh?=
HepG2.2.15	NEeyOVdCdnSrdnnyZYwh[XO\|YYm=		M2rXcFkh\GG7cx?=	M1\TbGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFNVSy2{ZYPpd5RidnRiSFLWJJdqfGhicH;sfY1memG\|ZTDMNVgxVSCvdYTheIlwdiCrbn\lZ5Rm\CCrbjDI[ZBIOi5{LkG1JINmdGy\|IHHzd4V{e2WmIHHzJI52[2ynaXOgZYNq\CCjbnSgdJJwfGWrbjDs[ZZmdHNiZH;z[YQh\GGrbImg[o9zKDliZHH5d{BidmRibXXhd5Vz\WRiMkSgbJJ{KGGodHXyJIxie3RidILlZZRu\W62IHL5JHNwfXSqZYLuJIJtd3RiaInidollcXqjdHnvckwhTUN3ME21MlPPxE1?	NXP2d4xpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNVc6OzBpPkKwNVE4QTNyPD;hQi=>
HepG2.2.15	MlPsRY51cX[rcnHsJIF{e2G7		MXu5JIRigXN?	M2DuUWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFNVSy2{ZYPpd5RidnRiSFLWJJdqfGhicH;sfY1memG\|ZTDMNVgxVSCvdYTheIlwdiCrbn\lZ5Rm\CCrbjDI[ZBIOi5{LkG1JINmdGy\|IHHzd4V{e2WmIHHzJI52[2ynaXOgZYNq\CCjbnSgdJJwfGWrbjDs[ZZmdHNiZH;z[YQh\GGrbImg[o9zKDliZHH5d{BidmRibXXhd5Vz\WRiMkSgbJJ{KGGodHXyJIxie3RidILlZZRu\W62IHL5JHNwfXSqZYLuJIJtd3RiaInidollcXqjdHnvckwhTUN7ME2yNO69VQ>?	M3K0WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUG3PVMxLz5{MEGxO\|k{ODxxYU6=
HepG2(2.2.15)	NXmySGJ1SW62aY\pdoFtKGG\|c3H5	NFvBR2oyOyC3TR?=	M4jzbFczKGi{cx?=	MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDI[ZBifGm2aYOgRkB3cXK3czDpcoZm[3SnZDDpckBpfW2jbjDI[ZBIOih{LkKuNVUqKGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHnueJJi[2WubIXsZZIhfmm{YXygSG5CKGyndnXsJIF1KDF\|IIXNJIFnfGW{IEeyJIhzeyCkeTDSWE1RS1JiYX7hcJl{cXN?	NEP2TXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG3Olg6Oyd-MkCxO\|Y5QTN:L3G+
HEK293	MYrBcpRqfmm{YXygZZN{[Xl?		NF\aU\|U4OiCqcoO=	NIjJc3NCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIIP1ZpR6eGViRDDpd49t[XSnIEigbY5n\WO2ZXSgbY4hUEWNMkmzJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMhemWybHnjZZRqd25iYX\0[ZIhPzJiaILzMEBGSzVyPUOuNlXPxE1?	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODNyOEO3O{c,OjB\|MEizO\|c9N2F-
HEK293	M2HnN2FvfGm4aYLhcEBie3OjeR?=		NUjKOWFYPzJiaILz	MmqxRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSC\|dXL0fZBmKEFiaYPvcIF1\SBzIHnu[oVkfGWmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzJJJmeGyrY3H0bY9vKGGodHXyJFczKGi{czygSWM2OD1\|LkW0{txO	Mnz5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB\|MEizO\|coRjJyM{C4N\|c4RC:jPh?=
HEK293	MlTNRY51cX[rcnHsJIF{e2G7		M33OS\|czKGi{cx?=	NYDCOoN4SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDzeYJ1gXCnIFOgbZNwdGG2ZTC2JIlv\mWldHXkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KHKncHzpZ4F1cW:wIHHmeIVzKDd{IHjyd{whTUN3ME2zMlnPxE1?	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODNyOEO3O{c,OjB\|MEizO\|c9N2F-
HEK293	NV7DU29xSW62aY\pdoFtKGG\|c3H5		M{nsNVczKGi{cx?=	Mn:1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSC\|dXL0fZBmKENiaYPvcIF1\SB5IHnu[oVkfGWmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzJJJmeGyrY3H0bY9vKGGodHXyJFczKGi{czygSWM2OD12LkC2{txO	M1vZRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{C4N\|c4Lz5{MEOwPFM4PzxxYU6=
HEK293	MUDBcpRqfmm{YXygZZN{[Xl?		M4KxblczKGi{cx?=	NUXpdpltSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDzeYJ1gXCnIFLGJIl{d2yjdHWgOUBqdm[nY4Tl[EBqdiCKRVuyPVMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2eyC{ZYDsbYNifGmxbjDh[pRmeiB5MjDodpMtKEWFNUC9OE4zPM7:TR?=	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODNyOEO3O{c,OjB\|MEizO\|c9N2F-
HEK293	NF63OHlCdnSrdnnyZYwh[XO\|YYm=		M2LEcFczKGi{cx?=	M3rNdmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFic4XieJlx\SCDIHnzc4xifGViMjDpcoZm[3SnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{Bz\XCuaXPheIlwdiCjZoTldkA4OiCqcoOsJGVEPTB;ND60PO69VQ>?	M3e0[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{C4N\|c4Lz5{MEOwPFM4PzxxYU6=
HEK293	M1PwRmFvfGm4aYLhcEBie3OjeR?=		M4DnXlczKGi{cx?=	MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYyKE6OND2zJIlv\mWldHXkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KHKncHzpZ4F1cW:wIHHmeIVzKDd{IHjyd{whTUN3ME20MlY5\|ryP	M3O3O\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{C4N\|c4Lz5{MEOwPFM4PzxxYU6=
HEK293	MUjBcpRqfmm{YXygZZN{[Xl?		NGHSfpQ4OiCqcoO=	NIfCc25CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIIP1ZpR6eGViQjDpd49t[XSnIEOgbY5n\WO2ZXSgbY4hUEWNMkmzJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMhemWybHnjZZRqd25iYX\0[ZIhPzJiaILzMEBGSzVyPUSuO\|jPxE1?	MmezQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB\|MEizO\|coRjJyM{C4N\|c4RC:jPh?=
HEK293	MlrKRY51cX[rcnHsJIF{e2G7		M2TyOVczKGi{cx?=	MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYyKHO3YoT5dIUhSiCrc3;sZZRmKDRiaX7m[YN1\WRiaX6gTGVMOjl\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yhfmm{dYOgdoVxdGmlYYTpc44h[W[2ZYKgO\|IhcHK\|LDDFR\|UxRTVwNEROwG0>	MofsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB\|MEizO\|coRjJyM{C4N\|c4RC:jPh?=
HEK293	MWnBcpRqfmm{YXygZZN{[Xl?		M1\FO\|czKGi{cx?=	NFvtc\|ZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIHX4dJJme3OrbnegdoV3\XK\|ZTD0doFve2O{aYD0ZZNmKEtzMEPOM3kyQDGFL1exPVBCKG23dHHueEBqdm[nY4Tl[EBqdiCKRVuyPVMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2eyC{ZYDsbYNifGmxbjDh[pRmeiB5MjDodpMtKEWFNUC9O{4yPs7:TR?=	M1z4[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{C4N\|c4Lz5{MEOwPFM4PzxxYU6=
HepG2(2.2.15)	NXH6OldDSW62aY\pdoFtKGG\|c3H5		NW\wUFdPQCCmYYnz	NV[zbGFESW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGWyYYTpeIl{KEJidnnyeZMhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJIN6fG:ybHHzcYlkKESQQTDzfY51cGW\|aYOgZYZ1\XJiODDkZZl{KGK7IGLUMXBEWiCjbnHsfZNqeyxiSVO1NF0xNjF4zszN	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ\|OUGxNEc,OjB4M{mxNVA9N2F-
HepG2(2.2.15)	M4DhcmN6fG:2b4jpZ4l1gSCjc4PhfS=>		M2DYWFgh\GG7cx?=	Ml:wR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{Bi\nSncjC4JIRigXNiYomgUXRVKGG\|c3H5MEBESzVyPUZOwG0>	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ\|OUGxNEc,OjB4M{mxNVA9N2F-
MT2	MorYRY51cX[rcnHsJIF{e2G7		MWSyJJRwKDNiZHH5dy=>	NWTzboZjSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbY1ufW6xZHXmbYNq\W6leTD2bZJ2eyBzIEPCJIlv\mWldHXkJIlvKGi3bXHuJG1VOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW\|IHnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RibXXhd5Vz\WRiYX\0[ZIhOiC2bzCzJIRigXNiYomgVGNTNCCHQ{WwQVAvQM7:TR?=	NF\xdVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGxOVc6PCd-MkGxNVU4QTR:L3G+
MT2	NV7vNll1SW62aY\pdoFtKGG\|c3H5			M3PGRWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHntcZVvd2SnZnnjbYVv[3lidnnyeZMhOSB\|QjDoZZJjd3KrbnegdoV3\XK\|ZTD0doFve2O{aYD0ZZNmKE1zOETWMEBOOTh2STDteZRidnRiaX7m[YN1\WRiaX6gbJVu[W5iTWSyJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMhcW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEB{\WynY4Tl[EBwdiCmYYmgNVQh[W[2ZYKgOEBx[XO\|YXfld{BjgSCSQ2KgZY5idHm\|aYOsJGVEPTB;MD64{txO	NXfMTW57RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNVU4QTRpPkKxNVE2Pzl2PD;hQi=>
MT2	MoDaRY51cX[rcnHsJIF{e2G7			M{fRPWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHntcZVvd2SnZnnjbYVv[3lidnnyeZMhOSB\|QjDoZZJjd3KrbnegdoV3\XK\|ZTD0doFve2O{aYD0ZZNmKE1zOETWJI12fGGwdDDpcoZm[3SnZDDpckBpfW2jbjDNWFIh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2eyCrbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KHOnbHXjeIVlKG:wIHThfUAyPCCjZoTldkA1KHCjc4Ph[4V{KGK7IGDDVkBidmGueYPpd{whTUN3ME2wMljPxE1?	NUXi[XJLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNVU4QTRpPkKxNVE2Pzl2PD;hQi=>
MT2	M4G0TWFvfGm4aYLhcEBie3OjeR?=			MnHoRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaX3teY5w\GWoaXPp[Y5kgSC4aYL1d{AyKDOEIHjhdoJwemmwZzDy[ZZmenOnIITyZY5{[3KrcIThd4UhVTF6NG[sJG0yQDSLLDDLPFJPKG23dHHueEBqdm[nY4Tl[EBqdiCqdX3hckBOXDJiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDpcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IIPlcIVkfGWmIH;uJIRigSBzNDDh[pRmeiB2IIDhd5Ni\2W\|IHL5JHBEWiCjbnHsfZNqNCCHQ{WwQVAvQM7:TR?=	NIHRO2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGxOVc6PCd-MkGxNVU4QTR:L3G+
HepG2(2.2.15)	MYrBcpRqfmm{YXygZZN{[Xl?			MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDI[ZBifGm2aYOgRkB3cXK3czDpcoZm[3SnZDDpckBpfW2jbjDI[ZBIOih{LkKuNVUqKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCCGTlGgZpkhW2:3dHjldo4h[myxdITpcoctKEWFNUC9NE4xPs7:TR?=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN\|M{WzOUc,OjF\|M{O1N\|U9N2F-
Huh7	M{Lhe2FvfGm4aYLhcEBie3OjeR?=		NGezZlUyKGSjeR?=	MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDI[ZBifGm2aYOgRkB3cXK3czDpcoZm[3SnZDDpckBpfW2jbjDIeYg4KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCCGTlGgZYZ1\XJiMTDkZZkh[nliU3;1eIhmem5iYnzveJRqdmduIFXDOVA:OC5zzszN	NEG2OGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzN\|U{PSd-MkGzN\|M2OzV:L3G+
HuH7	MXHDfZRwfG:6aXPpeJkh[XO\|YYm=		M1X1[VQh\GG7cx?=	MmK0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVJPyClZXzsd{Bi\nSncjC0JIRigXNiYomgcoV2fHKjbDDy[YQh\HmnIIXweIFs\SCjc4PhfUwhS0N3ME2wMlHPxE1?	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN\|M{WzOUc,OjF\|M{O1N\|U9N2F-
HepG2(2.2.15)	MnPCRY51cX[rcnHsJIF{e2G7		MWq0JIRigXN?	MVvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDI[ZBifGm2aYOgRkB3cXK3czDpcoZm[3SnZDDpckBpfW2jbjDI[ZBIOih{LkKuNVUqKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxiRF7BJJJmeGyrY3H0bY9vKGGodHXyJFQh\GG7czDifUBTXC2SQ2KgZY5idHm\|aYOsJGlEPTB;MD6zN:69VQ>?	MnnFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MkS1PFgoRjJzNUK0OVg5RC:jPh?=
HepG2(2.2.15)	MWfBcpRqfmm{YXygZZN{[Xl?		M3;jNlkh\GG7cx?=	NHnXS4ZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymIIT5dIUhUGWyYYTpeIl{KEJidnnyeZMhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzJJJmeGyrY3H0bY9vKHS{ZXH0[YQh\GGrbImg[o9zKDliZHH5d{BjgSCzdXHueIl1[XSrdnWgZoxwfCCqeXLybYRqgmG2aX;uJI1mfGixZDygSWM2OD1yLkNOwG0>	M{PTcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUOwN\|c4Lz5{MUmzNFM4PzxxYU6=
HepG2(2.2.15)	NHfa[3FCdnSrdnnyZYwh[XO\|YYm=		NEHUbpU6KGSjeYO=	NFrWUWtCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GWob4\pdk1z\XOrc4ThcpQhUGWyYYTpeIl{KEJidnnyeZMhcGG{Yn;ybY5oKHKndnXyd4UhfHKjboPjdolxfGG\|ZTDONlM3XCCvdYThcpQhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzJJJmeGyrY3H0bY9vKHS{ZXH0[YQh\GGrbImg[o9zKDliZHH5d{BjgSCzdXHueIl1[XSrdnWgZoxwfCCqeXLybYRqgmG2aX;uJI1mfGhuIFXDOVA:OC5{zszN	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl\|MEO3O{c,OjF7M{CzO\|c9N2F-
HepG2(2.2.15)	NUfnendySW62aY\pdoFtKGG\|c3H5		MlfNPUBl[Xm\|	MmDSRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\CC2eYDlJGhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{KEKuNk4yPSliY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJIlv\mWldHnveZMhfmm{dYOgeIl1\XJidILlZZRm\CCmYXnsfUBnd3JiOTDkZZl{KGK7IIH1ZY51cXSjdHn2[UBUd3W2aHXyckBjdG:2IHj5ZpJq\Gm8YYTpc44h[XO\|YYmsJGVEQTB;MD62{txO	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl\|MEO3O{c,OjF7M{CzO\|c9N2F-
HepG2(2.2.15)	NYPWcVFOSW62aY\pdoFtKGG\|c3H5		NXzwR40{QSCmYYnz	M1\iXWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl\W[xdnnyMZJme2m\|dHHueEBJ\XCjdHn0bZMhSiC4aYL1d{Bp[XKkb4LpcochemW4ZYLz[UB1emGwc3PybZB1[XOnIF6yN\|ZVKG23dHHueEBqdm[nY4Tl[EBqdiCqdX3hckBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDv[kBqdm[nY4Tpc5V{KH[rcoXzJJRqfGW{IITy[YF1\WRiZHHpcJkh\m:{IEmg[IF6eyCkeTDxeYFvfGm2YYTpeoUhW2:3dHjldo4h[myxdDDofYJzcSxiRVO5NF0xNjoQvF2=	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl\|MEO3O{c,OjF7M{CzO\|c9N2F-
HepG2(2.2.15)	NYn1dWN7SW62aY\pdoFtKGG\|c3H5		NHfhR3Y6KGSjeYO=	M4rHWGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIxidWm4dXTpcoUuemW\|aYP0ZY51KEincHH0bZRqeyCEII\pdpV{KGijcnLvdolv\yC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUFE5OE1ibYX0ZY51KGmwZnXjeIVlKGmwIHj1cYFvKEincFeyLFIvOi5zNTmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{Bz\XCuaXPheIlwdiC2cnXheIVlKGSjaXz5JIZweiB7IHThfZMh[nlicYXhcpRqfGG2aY\lJIJtd3RiaInidollcXqjdHnvckBu\SxiRVO1NF0yNjYQvF2=	NWXWcWhYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5N\|A{PzdpPkKxPVMxOzd5PD;hQi=>
HepG2(2.2.15)	Mlu5RY51cX[rcnHsJIF{e2G7		NYTnNYpbQSCmYYnz	M2izfmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIxidWm4dXTpcoUuemW\|aYP0ZY51KEincHH0bZRqeyCEII\pdpV{KGijcnLvdolv\yC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUFE5OE1ibYX0ZY51KGmwZnXjeIVlKGmwIHj1cYFvKEincFeyLFIvOi5zNTmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKGmwZnXjeIlwfXNidnnyeZMhfGm2ZYKgeJJm[XSnZDDkZYltgSCob4KgPUBl[Xm\|IHL5JJF2[W62aYTheIl3\SCVb4X0bIVzdiCkbH;0JIh6[ixiRVO5NF0zOs7:TR?=	MnPyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7M{CzO\|coRjJzOUOwN\|c4RC:jPh?=
HeLa P4/R5	M{PyNmFvfGm4aYLhcEBie3OjeR?=		M362UVIhcHK\|	MYnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYyKEKjTDDpcoZm[3SnZDDpckBJ\UyjIGC0M3I2KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJidCCrbn\lZ5Rqd25iaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBqdmO3YnH0[YQhcW5iZIL1[{1nemWnIH3l[Il2dSCob4KgOFYhcHK\|IHL5JJNqdmeuZTDyc5Vv\CCrbn\lZ5Rqd25iYnX0ZU1o[WyjY4Tvd4ll[XOnIILldI9zfGW{IHflcoUh[XO\|YYmsJGVEPTB;MUGuN:69VQ>?	M2nITFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{WyPFA6Lz5{MkO1NlgxQTxxYU6=
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CEM-SS	Mk\VRY51cX[rcnHsJIF{e2G7		NXHofYc2PiCmYYnz	NWr5cWVUSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYLUGgd5VjfHmyZTCzRkBqdm[nY4Tl[EBqdiCFRV2tV3Mh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB4IHThfZMh[nliWGTUJIF{e2G7LDDFR\|UxRTBwMt88US=>	Mmr0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUiwPVcoRjJ{OEW4NFk4RC:jPh?=
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HuH7	NFvJXFhCdnSrdnnyZYwh[XO\|YYm=			NWnuU2ljSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEincHH0bZRqeyCEII\pdpV{KGmwZnXjeIVlKGmwIHj1cYFvKEi3SEegZ4VtdHNuIFXDPVA:OC5zNENOwG0>	MlTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{M{e4OFEoRjJ\|MkO3PFQyRC:jPh?=
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CEM	MknVRY51cX[rcnHsJIF{e2G7		NGjBdZM1KGSjeYO=	NUHuOW9RSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTCzRkBqdm[nY4Tl[EBqdiCqdX3hckBETU1iY3XscJMh[XO\|ZYPz[YQh[XNidnnyeZMucW6mdXPl[EBocWGwdDDj[YxtKG[xcn3heIlwdiCjZoTldkA1KGSjeYOgZpkhdWmlcn;zZ49xcWNiYX7hcJl{cXNuIFXDOVA:OC5yOUpOwG0>	M33JZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUe3N\|U6Lz5{NEG3O\|M2QTxxYU6=
CEM	NYn0eXZ5SW62aY\pdoFtKGG\|c3H5		M4KwTlQh\GG7cx?=	NIPP[4hCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZ{IGLPSEBqdm[nY4Tl[EBqdiCqdX3hckBETU1iY3XscJMh[XO\|ZYPz[YQh[XNidnnyeZMucW6mdXPl[EBocWGwdDDj[YxtKG[xcn3heIlwdiCjZoTldkA1KGSjeYOgZpkhdWmlcn;zZ49xcWNiYX7hcJl{cXNuIFXDOVA:OC5zON88US=>	NVzHZ5I4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxO\|c{PTlpPkK0NVc4OzV7PD;hQi=>
HOG.R5	M4nodGFvfGm4aYLhcEBie3OjeR?=			MnnlRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXNTFiM1KvTFkhcW6oZXP0[YQhcW5iaIXtZY4hUE:JLmK1JINmdGy\|IITyZY5{\mWldHXkJJdqfGhiSFnWNUBNXFJvR1\QJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZpkh\my3b4Lld4NmdmOnIHHuZYx6e2m\|LDDJR\|UxRTFwMt88US=>	NGrkNXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NESwOFc2Pyd-MkS0NFQ4PTd:L3G+
MT4	MonZRY51cX[rcnHsJIF{e2G7			MmC3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSB\|QjDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImgcYVie3W{ZXSgOUBl[Xm\|IIDvd5Qhfmm{YXygbY5n\WO2aX;uJIJ6KE2WVDDhd5NigSxiRVO1NF0zNjR2Mt88US=>	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd7NEe1NUc,OjR5OUS3OVE9N2F-
MT4	MVTBcpRqfmm{YXygZZN{[Xl?			MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYzKFKRRDDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImgcYVie3W{ZXSgOUBl[Xm\|IIDvd5Qhfmm{YXygbY5n\WO2aX;uJIJ6KE2WVDDhd5NigSxiRVO1NF04NjMQvF2=	NV3DdIl6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3PVQ4PTFpPkK0O\|k1PzVzPD;hQi=>
MT4	MUHBcpRqfmm{YXygZZN{[Xl?		NH7kd2o2KGSjeYO=	NE\MUmpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDpcY12dm:mZX\pZ4lmdmO7II\pdpV{KDFiM3KgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNicnXwcIlk[XSrb36gZYZ1\XJiNTDkZZl{KGK7IF3UWEBie3OjeTygTWM2OD1\|LkpOwG0>	M4f0fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUK2PFA4Lz5{NEmyOlgxPzxxYU6=
MT4	MmfPRY51cX[rcnHsJIF{e2G7		MXi1JIRigXN?	MoG0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iaX3teY5w\GWoaXPp[Y5kgSC4aYL1d{B1gXCnIEKgVm9FKGmwZnXjeIVlKGmwIHj1cYFvKE2WNDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcoXzJJJmeGyrY3H0bY9vKGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEmFNUC9NVUvPc7:TR?=	NYHhcVdERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NlY5ODdpPkK0PVI3QDB5PD;hQi=>
MT4	M1rhO2FvfGm4aYLhcEBie3OjeR?=		NEPhOVA2KGSjeYO=	NXLPUpNzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiLVkGgN2IhcW6oZXP0[YQhcW5iaIXtZY4hVVR2IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aH;n[Y5q[2m2eTDh[pRmeiB3IHThfZMh[nliTWTUJIF{e2G7LDDJR\|UxRTNwOEpOwG0>	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3MkOwOUc,OjR7NUKzNFU9N2F-
MT4	M2i0[GFvfGm4aYLhcEBie3OjeR?=		MWq1JIRigXN?	MojjRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOiCUT1SgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCjZoTldkA2KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVE2NjV\|zszN	NIrs[ow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm1NlMxPSd-MkS5OVI{ODV:L3G+
HepG2.2.15	MoHoRY51cX[rcnHsJIF{e2G7			M{HKRWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{LkKuNVUh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjygTWM2OD1zND6xO:69VQ>?	M2[1WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUK3NVA1Lz5{NUGyO\|ExPDxxYU6=
MT4	NYnRUmV2SW62aY\pdoFtKGG\|c3H5		NH22ZnY2KGSjeYO=	M{i1fGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiM1KgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CC\|eX7jfZRqfW1iZn;ycYF1cW:wIHHmeIVzKDViZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:Oi5{Mt88US=>	NID6UIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK0NFA6PSd-MkWyOFAxQTV:L3G+
MT4	MlHXRY51cX[rcnHsJIF{e2G7		MoHsOUBl[Xm\|	MWrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYzKFKRRDDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKHO7bnP5eIl2dSCob4LtZZRqd25iYX\0[ZIhPSCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF05NjhzzszN	MoLZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{NECwPVUoRjJ3MkSwNFk2RC:jPh?=
HepG2(2.2.15)	NIP6bYVHfW6ldHnvckBie3OjeR?=	NETWS2gxNjd3IITvJFMhfU1?	NX:4WphUPzJiaILz	M3XQTGRm[3KnYYPlJIlvKEiEVjD2bZJidCCGTlGgdoVxdGmlYYTpc44hcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjdDCwMlc2KHSxIEOgeW0h[W[2ZYKgO\|IhcHK\|IHL5JJJm[WxvdHnt[UBRS1JiYX7hcJl{cXNuIFnDOVA:Py54M988US=>	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR4MUi5NUc,OjV2NkG4PVE9N2F-
MT4	NEC3OJJCdnSrdnnyZYwh[XO\|YYm=		M2LrdFUh\GG7cx?=	M{nISWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJUVZvMTCzRkBqdm[nY4Tl[EBqdiCqdX3hckBOXDRiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJZqenW\|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPSCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF0zNjJ2zszN	Ml\vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3M{e1N\|IoRjJ3NUO3OVMzRC:jPh?=
MT4	MkfWRY51cX[rcnHsJIF{e2G7		MX:1JIRigXN?	M3LENGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBJUVZvMjDSU2QhcW6oZXP0[YQhcW5iaIXtZY4hVVR2IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDViZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:QC55Od88US=>	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV\|N{WzNkc,OjV3M{e1N\|I9N2F-
MT4	MWPBcpRqfmm{YXygZZN{[Xl?		MkXyOUBl[Xm\|	MX7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYyKDOEIHnu[oVkfGWmIHnuJIh2dWGwIF3UOEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBi\nSncjC1JIRigXNiYomgUXRVKGG\|c3H5MEBGSzVyPUKuNlM6\|ryP	M2LLNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkK2NVQ2Lz5{NU[yOlE1PTxxYU6=
MT4	M3TsXWFvfGm4aYLhcEBie3OjeR?=		MXq1JIRigXN?	MXHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYyKDOEIHnu[oVkfGWmIHnu[oVkfGWmIHnuJIh2dWGwIF3UOEBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{dYOtbY5lfWOnZDDjfZRwfG:6aXPpeJkh[W[2ZYKgOUBl[Xm\|IHL5JG1VXCCjc4PhfUwhTUN3ME2wMlg6\|ryP	Mmf4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEK1OlIoRjJ3NkiyOVYzRC:jPh?=
MT4	M4P4UmFvfGm4aYLhcEBie3OjeR?=		MYe1JIRigXN?	M4XPR2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjJiUl;EJIlv\mWldHXkJIlvKGi3bXHuJG1VPCClZXzsd{Bie3Onc4Pl[EBieyCycn;0[YN1cW:wIHHnZYlve3RidnnyeZMucW6mdXPl[EBkgXSxdH;4bYNqfHliYX\0[ZIhPSCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF0{NjV4zszN	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6MkW2Nkc,OjV4OEK1OlI9N2F-
MT4	MV\BcpRqfmm{YXygZZN{[Xl?		NYrYeGV4PSCmYYnz	MlPYRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSB\|QjDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOUBl[Xm\|IHL5JG1VXCCjc4PhfUwhTUN3ME2yMlLPxE1?	NEC1NVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUewO\|AyOyd-MkW3NFcxOTN:L3G+
HepG2.2.15	NGjpO\|lCdnSrdnnyZYwh[XO\|YYm=			M3rNcmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{LkKuNVUh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDIRnYhTE6DIILldIxq[2G2aX;uJIJ6KHKnYXyteIlu\SCobIXvdoV{[2WwY3WgdZVidnSrdHH0bZZmKFCFUjDhcoFtgXOrczygTWM2OD14Lki2{txO	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh2N{e2OUc,OjV6NEe3OlU9N2F-
MT4	MXXBcpRqfmm{YXygZZN{[Xl?		MVW1JIRigXN?	NXv1Z\|F5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMT2zRkBqdm[nY4Tl[EBqdiCqdX3hckBOXDRiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDpcoR2[2WmIHPlcIwh\GWjdHigcYVie3W{ZXSgZYZ1\XJiNTDkZZl{KG:oIHnu[oVkfGmxbjDifUBOXFRiYYPzZZktKEWFNUC9N{46\|ryP	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl2NkGxOkc,OjV7NE[xNVY9N2F-
MT4	MWTBcpRqfmm{YXygZZN{[Xl?		NIPUfos2KGSjeYO=	NUTJZ5hqSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMj3SU2QhcW6oZXP0[YQhcW5iaIXtZY4hVVR2IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yhfmm{dYOgbY5lfWOnZDDj[YxtKGSnYYToJI1m[XO3cnXkJIFnfGW{IEWg[IF6eyCxZjDpcoZm[3Srb36gZpkhVVSWIHHzd4F6NCCHQ{WwQVE2NjYQvF2=	M1y0O\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUS2NVE3Lz5{NUm0OlEyPjxxYU6=
HepG22.2.15	NWLoPHdWSW62aY\pdoFtKGG\|c3H5		NEPS[3c{KGSjeYO=	NXvjRWJRSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFjldGczOi5{LkG1JINmdGy\|IHHmeIVzKDNiZHH5d{BjgSCwZYX0doFtKHKnZDDkfYUu[mG\|ZXSgdIxieXWnIILl[JVkfGmxbjDhd5NigSxiSVO1NF0xNjB\|Od88US=>	NXHBRZV3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOlA{OzZpPkK2NlYxOzN4PD;hQi=>
U87	NVLUfo1xSW62aY\pdoFtKGG\|c3H5	NGHrWYkyOCC3TR?=	NEX5OFI1KGSjeYO=	M{DaS2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXi1zIF7MOE0{KGmwZnXjeIVlKGmwIHj1cYFvKFV6NzDj[YxteyCneIDy[ZN{cW6pIFPEOE5EYEOUNDDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIICyOEBxem:mdXP0bY9vKGG2IEGwJJVOKG2nYYP1doVlKGGodHXyJFQh\GG7czDifUBxOjRiRVzJV2E>	NHe2NnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C5NVA4OCd-MkewPVExPzB:L3G+
U87	NGXPWmVCdnSrdnnyZYwh[XO\|YYm=	MVixNFAhfU1?	M2TvUVQh\GG7cx?=	M1LMZ2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXi1zIF7MOE0{KGmwZnXjeIVlKGmwIHj1cYFvKFV6NzDj[YxteyCneIDy[ZN{cW6pIFPEOE5EYEOUNDDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIICyOEBxem:mdXP0bY9vKGG2IEGwNEB2VSCvZXHzeZJm\CCjZoTldkA1KGSjeYOgZpkheDJ2IFXMTXNC	MmX0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyOUGwO\|AoRjJ5MEmxNFcxRC:jPh?=
MT4	M2fLfGFvfGm4aYLhcEBie3OjeR?=		NEfOO2Q2KGSjeYO=	M4\JVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiM1Kg[ZhxemW\|c3nu[{B4cWymIIT5dIUhemW4ZYLz[UB1emGwc3PybZB1[XOnIHnu[oVkfGWmIHnuJIh2dWGwIF3UOEBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB3IHThfZMh[nliTWTUJIF{e2G7LDDFR\|UxRTNwMd88US=>	MlLDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd{NkewNFUoRjJ5Mk[3NFA2RC:jPh?=
HepG2.2.15.7	M4DiZmFvfGm4aYLhcEBie3OjeR?=		MWq5JIRigXN?	NGPEW4xCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwS\|IvOi5zNT63JINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhTE6DIHzleoVtKGGodHXyJFkh\GG7czDifUBz\WGuIITpcYUhWEOUIH3leIhw\CxiRVO1NF0xNjB\|zszN	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR{NkOwN{c,Ojd2Mk[zNFM9N2F-
MT4	M2\Jd2FvfGm4aYLhcEBie3OjeR?=		MWm1JIRigXN?	NEDIVm1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymIIT5dIUhUEmYMTCzRkBp[XKkb4LpcochemW4ZYLz[UB1emGwc3PybZB1[XOnIHnu[oVkfGWmIHnuJIh2dWGwIF3UOEBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qhfmm{dYOgbY5lfWOnZDDjfZRwfG:6aXPpeJkh[W[2ZYKgOUBl[Xm\|IHL5JG1VXCCjc4PhfUwhTUN3ME2yMlI1\|ryP	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV2MUW3PEc,Ojd3NEG1O\|g9N2F-
MT4	NXvGOIIxSW62aY\pdoFtKGG\|c3H5		NGi3eoY2KGSjeYO=	NWHNXIRRSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMjDSU2QhcGG{Yn;ybY5oKHKndnXyd4UhfHKjboPjdolxfGG\|ZTDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO\|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KH[rcoXzJIlv\HWlZXSgZ5l1d3SxeHnjbZR6KGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9PE44Qc7:TR?=	MkOxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NEG1O\|goRjJ5NUSxOVc5RC:jPh?=
HepG2(2.2.15)	Mn;MRY51cX[rcnHsJIF{e2G7		MlHyOkBl[Xm\|	M{C3bmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCjeYexJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{KEKuNk4yPSliY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuIILldIxq[2G2aX;uJIJ6KG2nYYP1dolv\yCrboTyZYNmdGy3bHHyJJZqemGuIFTORUBkd3C7IH71cYJmeiCjZoTldkA3KGSjeYOgZpkhemWjbD30bY1mKHGSQ2KgcYV1cG:mLDDFR\|UxRDBwMEJOwG0>	M3vrUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{S4OVkxLz5{N{e0PFU6ODxxYU6=
HepG2(2.2.15)	MofjRY51cX[rcnHsJIF{e2G7		NYPvOVQ2PiCmYYnz	NUDWcFZySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHH5e\|EhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygdoVxdGmlYYTpc44h[nlibXXhd5VzcW6pIHX4eJJi[2WubIXsZZIhfmm{YXygSG5CKGOxcImgcpVu[mW{IHHmeIVzKDZiZHH5d{BjgSC{ZXHsMZRqdWVicWDDVkBu\XSqb3SsJGVEPTB;MD6wNe69VQ>?	MoXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NEi1PVAoRjJ5N{S4OVkxRC:jPh?=
MT4	M4exR2FvfGm4aYLhcEBie3OjeR?=		Mn3VOUBl[Xm\|	NV\XWHdPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTCzRkBqdm[nY4Tl[EBqdiCqdX3hckBOXDRiY3XscJMh[XO\|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2II\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOUBl[Xm\|IHL5JG1VXCCjc4PhfUwhTUN3ME2yMlIz\|ryP	M37PelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{S4OVkxLz5{N{e0PFU6ODxxYU6=
MT4	NXnIS\|R{SW62aY\pdoFtKGG\|c3H5		NXjwRoV5PSCmYYnz	MnSxRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOiCUT1SgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W\|c3XkJIF{KHC{b4TlZ5Rqd25iYXfhbY5{fCC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IEWg[IF6eyCkeTDNWHQh[XO\|YYmsJGVEPTB;OD64Ne69VQ>?	M2n1SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{S4OVkxLz5{N{e0PFU6ODxxYU6=
Huh7	M1f6U2FvfGm4aYLhcEBie3OjeR?=			M{X1dGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIxidWm4dXTpcoUuemW\|aYP0ZY51KHerbHSgeJlx\SCqZYDheIl1cXNiQjD2bZJ2eyCrbn\lZ5Rm\CCrbjDoeY1idiCKdXi3JINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC\|ZXPy[ZRm\CCGTlGgcIV3\Wy\|IH3lZZN2emWmIH;uJIRigSB5IHL5JJJm[WxvdHnt[UBRS1JiYX7hcJl{cXNuIFXDOVA:OC5yNUZOwG0>	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6MkC2PEc,OjhyOEKwOlg9N2F-
HepG2.215	NY\jbWQ1SW62aY\pdoFtKGG\|c3H5			NWPQXIxJSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcGWyYYTpeIl{KEJidnnyeZMhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KuNlE2KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCCGTlGgdoVxdGmlYYTpc44hdWWjc4Xy[YQhd25iZHH5JFch[nlicnXhcEB1cW2nIGDDVkBidmGueYPpd{whTUN3ME2wMlHPxE1?	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6MkC2PEc,OjhyOEKwOlg9N2F-
Huh7	NFf1fIhCdnSrdnnyZYwh[XO\|YYm=			NVXEc4pWSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhdGGvaY\1[Ilv\S2{ZYPpd5RidnRid3ns[EB1gXCnIHjldIF1cXSrczDCJJZqenW\|IHnu[oVkfGWmIHnuJIh2dWGwIFj1bFch[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHnueJJi[2WubIXsZZIhTE6DIHzleoVteyCvZXHzeZJm\CCxbjDkZZkhPyCkeTDy[YFtNXSrbXWgVGNTKGGwYXz5d4l{NCCHQ{WwQVAvOjN5zszN	M1jMXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEiyNFY5Lz5{OEC4NlA3QDxxYU6=
HepG2.215	M1vmeWFvfGm4aYLhcEBie3OjeR?=			M13mVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{LkKxOUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwhTE6DIILldIxq[2G2aX;uJI1m[XO3cnXkJI9vKGSjeTC3JIJ6KHKnYXygeIlu\SCSQ2KgZY5idHm\|aYOsJGVEQTB;Mt88US=>	NX6zOJJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFIxPjhpPkK4NFgzODZ6PD;hQi=>
HepAD38	MXjBcpRqfmm{YXygZZN{[Xl?		NEXqZ\|I2KGSjeYO=	NHfHRZlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwRWQ{QCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGRPSSC{ZYDsbYNifGmxbjDh[pRmeiB3IHThfZMh[nliUmStVGNTKG2ndHjv[EwhTUN3ME2wMlA1\|ryP	M{C1PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEm0NVc6Lz5{OEC5OFE4QTxxYU6=
P4R5 MAGI	MkLmSpVv[3Srb36gZZN{[Xl?		M2rBflIhcHK\|	M4W4RWlvcGmkaYTpc44hd2ZiSFnWNUBD[UxiZHnueYNt\W:\|aXTlJJJmfmW{c3WgeJJidnOlcnnweIF{\SCrbn\lZ5Rm\CCrbjDoeY1idiCSNGK1JG1CT0liY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuIHnu[oVkfGmxbjDh[pRmeiB{IHjyd{BjgSCJYXzhZ5RwNVO2YYKgZoV1[S2pYXzhZ5Rwe2mmYYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NVEvO87:TR?=	NEPSblk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO1NVU5QCd-MkizOVE2QDh:L3G+
P4R5 MAGI	MmP3SpVv[3Srb36gZZN{[Xl?		NWXITWZIOiCqcoO=	NGP3WHZKdmirYnn0bY9vKG:oIFjJWlEhO0JiZHnueYNt\W:\|aXTlJJJmfmW{c3WgeJJidnOlcnnweIF{\SCrbn\lZ5Rm\CCrbjDoeY1idiCSNGK1JG1CT0liY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuIHnu[oVkfGmxbjDh[pRmeiB{IHjyd{BjgSCJYXzhZ5RwNVO2YYKgZoV1[S2pYXzhZ5Rwe2mmYYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9N\|IvP87:TR?=	MojxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|NUG1PFgoRjJ6M{WxOVg5RC:jPh?=
HepG2.2.15	M2HwU2FvfGm4aYLhcEBie3OjeR?=		M3HnOVgh\GG7cx?=	MVPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDI[ZBifGm2aYOgRkB3cXK3czDpcoZm[3SnZDDpckBpfW2jbjDI[ZBIOi5{LkG1JINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhTE6DIILldIxq[2G2aX;uJIFnfGW{IEig[IF6eyCkeTDy[YFtKHSrbXWg[ox2d3Knc3PlcpQhWEOUIH3leIhw\CxiSVO1NF0xNjYQvF2=	NGfYNHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES5OFI2Oid-Mki0PVQzPTJ:L3G+
MT4	NHGwb2hCdnSrdnnyZYwh[XO\|YYm=		Mo\OOUBl[Xm\|	NHzyd3RCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymIIT5dIUhUEmYMTCzRkBqdm[nY4Tl[EBqdiCqdX3hckBOXDRiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDViZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:Oi53NN88US=>	MlvQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUmyOFYoRjJ6NkW5NlQ3RC:jPh?=
HepG2(2.2.15)	M2jEUmFvfGm4aYLhcEBie3OjeR?=		MVG2JIRigXN?	Mor3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGG7d{GgbY5n\WO2ZXSgbY4hcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxicnXwcIlk[XSrb36gZpkhdWWjc4XybY5oKGmwdILhZ4VtdHWuYYKgeolz[WxiRF7BJINweHliboXtZoVzKGGodHXyJFYh\GG7czDifZIh[nlicnXhcE11cW2nIIHQR3Ih[XO\|YYmsJGVEPTB;MD6wNFg5P87:TR?=	M362SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkiyNFY4Lz5{OE[4NlA3PzxxYU6=
HepG2(2.2.15)	NILLR2hCdnSrdnnyZYwh[XO\|YYm=		NEL6NWE3KGSjeYO=	Ml7vRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGG7d{GgbY5n\WO2ZXSgbY4hcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxicnXwcIlk[XSrb36gZpkhdWWjc4XybY5oKGW6dILhZ4VtdHWuYYKgeolz[WxiRF7BJINweHliboXtZoVzKGGodHXyJFYh\GG7czDifUBz\WGuLYTpcYUheVCFUjDt[ZRpd2RuIFXDOVA:OC5yMt88US=>	NH7RVGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[4NlA3Pyd-Mki2PFIxPjd:L3G+
HepAD38	MYTBcpRqfmm{YXygZZN{[Xl?			MmnqRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN\|gh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHnueJJi[2WubIXsZZIhfmm{YXygSG5CKGyndnXsJIJ6KFKWLWDDVkBu\XSqb3SsJGVEPTB:MD6wNe69VQ>?	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6OEK4NEc,Ojh4OEiyPFA9N2F-
HepAD38	M33YN2FvfGm4aYLhcEBie3OjeR?=			NGrNVoNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwRWQ{QCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxicnXwcIlk[XSrb36gZpkhWlRvUFPSJI1mfGixZDygSWM2OD1yLkC0{txO	M376PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Nki4NlgxLz5{OE[4PFI5ODxxYU6=
HepAD38	NIKxZpNCdnSrdnnyZYwh[XO\|YYm=			MnvwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN\|gh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHX4eJJi[2WubIXsZZIhfmm{YXygSG5CKGyndnXsJIJ6KFKWLWDDVkBu\XSqb3SsJGVEPTB;MD6wOO69VQ>?	MkXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEiyPFAoRjJ6Nki4NlgxRC:jPh?=
HepAD38	NXnRNotSSW62aY\pdoFtKGG\|c3H5			MkSzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN\|gh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwII\pdoFtKHKncHzpZ4F1cW:wIHL5JHJVNVCFUjDt[ZRpd2RuIFXDPVA:OC5\|zszN	NFHTO5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[4PFI5OCd-Mki2PFgzQDB:L3G+
HepAD38	MUXBcpRqfmm{YXygZZN{[Xl?			NFyzZmlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwRWQ{QCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6g[Zh1emGlZXzseYxieiC4aYLhcEBFVkFibHX2[Ywh[nliUmStVGNTKG2ndHjv[EwhTUN7ME2wMlPPxE1?	MljmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEiyPFAoRjJ6Nki4NlgxRC:jPh?=
HepAD38	M1jrTmFvfGm4aYLhcEBie3OjeR?=			NVe2bmlESW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFjldGFFOzhiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJIlvfHKjY3XscJVt[XJidnnyZYwhTE6DIHzleoVtKGK7IGLUMXBEWiCvZYToc4QtKEWFOUC9NE44\|ryP	MlK0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEiyPFAoRjJ6Nki4NlgxRC:jPh?=
SupT1	M2HCdmFvfGm4aYLhcEBie3OjeR?=		MXq0PEBpenN?	MVTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDWV3YuTyCyc3X1[I91gXCnZDDITXYyKGmwZnXjeIVlKGmwIHj1cYFvKFO3cGSxJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO\|YYmsJGlEPTB;MD6x{txO	M1:5SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEG2NVMyLz5{OUCxOlE{OTxxYU6=
HepG2(2.2.15)	M2rFc2FvfGm4aYLhcEBie3OjeR?=		NU\6NIRbPiCmYYnz	NGDFS4ZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwS\|IpOi5{LkG1LUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKESQQTDy[ZBtcWOjdHnvckBi\nSncjC2JIRigXNiYomgVnQuWEOUIH3leIhw\CxiSVO1NFwxNjIQvF2=	M2SwS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki4PVQ{Lz5{OUK4PFk1OzxxYU6=
A549	NHT2NFJCdnSrdnnyZYwh[XO\|YYm=			MkjVRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSC4aYLpc45{KGSncnn2[YQh\nKxbTDITXYwXlOJLVegc5IhUEmYL1jBJJZqemmxboOgbY5n\WO2ZXSgNlk{XCClZXzsd{B2e2mwZzDoeY1idiCDNUS5JINmdGy\|IHHzJJRiemendDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKHW\|aX7nJINwdXCxdX7kJJBz\S2vaYjl[EB3cXKrb37zJIZwdGyxd3XkJIJ6KGmwY4XiZZRqd25id3n0bEB1[XKpZYSgZ4VtNCCLQ{WwQVAvPTIQvF2=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ7OUmyOEc,Ojl4OUm5NlQ9N2F-
HepG2.2.15	MnrkRY51cX[rcnHsJIF{e2G7		NGfGZY83KGSjeYO=	NFzLOppCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XCjdHn0bZMhSiC4aYL1d{Bqdm[nY4Tl[EBqdiCqdX3hckBJ\XCJMj6yMlE2KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDlfJRz[WOnbHz1cIFzKH[rcnHsJGRPSSCuZY\lcJMh[W[2ZYKgOkBl[Xm\|IHL5JJFRS1JxVHHxUYFvKGG\|c3H5MEBKSzVyPUCuNFI2\|ryP	NFjURoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEK4OlI6Oid-M{CyPFYzQTJ:L3G+
MT4	MlHURY51cX[rcnHsJIF{e2G7		NVrORlBNPSCmYYnz	NVH6dnhnSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDSSXMxPTZiY3;ueIFqdmmwZzDy[ZZmenOnIITyZY5{[3KrcIThd4UhUzFyM16gL{B[OThzQzDteZRidnRiaX7m[YN1\WRiaX6gbJVu[W5iTWS0JINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBi\nSncjC1JIRigXNiYomgUXRVKGG\|c3H5MEBGSzVyPUeuO\|fPxE1?	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODZyNk[3NEc,OzB4ME[2O\|A9N2F-
MT4	NVTvUYNESW62aY\pdoFtKGG\|c3H5		M1;LVlUh\GG7cx?=	NVjkbmNsSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiLVkGgN2IhcW6oZXP0[YQhcW5iaIXtZY4hVVR2IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB3IHThfZMh[nliTWTUJIF{e2G7LDDFR\|UxRTF{LklOwG0>	M1iyVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNkC2OlcxLz5\|ME[wOlY4ODxxYU6=
MT4	MkLHRY51cX[rcnHsJIF{e2G7		MkL2OUBl[Xm\|	NHHobVNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIEPCJIlv\mWldHXkJIlvKGi3bXHuJG1VPCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW\|LXnu[JVk\WRiY4n0c5RwgGmlaYT5JIFnfGW{IEWg[IF6eyCkeTDNWHQh[XO\|YYmsJGVEPTB;Nj60Ne69VQ>?	M4HHbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyN{KxNFYxLz5\|MEeyNVA3ODxxYU6=
HepG2.2.15	Mli5SpVv[3Srb36gZZN{[Xl?	MnriOEB2VQ>?	M4nKVlYh\GG7cx?=	NHLuflNKdmirYnn0bY9vKG:oIHPhdJNq\CCycn;0[YlvKGmwIFjldIF1cXSrczDCJJZqenW\|IHnu[oVkfGWmIHnuJIh2dWGwIFjldGczNjJwMUWgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcnHsJGRPSSCuZY\lcEBifCB2IIXNJJN2eHCuZX3lcpRm\CC5aYToJIZz\XOqIH3l[Il2dSClb370ZYlvcW6pIHPvcZBwfW6mIHX2[ZJ6KDJiZHH5d{BidmRibXXhd5Vz\WRiYX\0[ZIhPiCmYYnzJIJ6KFKWLWDDVkBidmGueYPpd{whUUN3MEywMlHPxE1?	Mn7VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFyOUG0O\|koRjNzMEmxOFc6RC:jPh?=
HepG2.2.15	NGC4fGVCdnSrdnnyZYwh[XO\|YYm=			MVzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDIRnYhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KuNk4yPSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ5l1d3CuYYPtbYMhTE6DIIP5cpRp\XOrczDifUBz\WWmIHHu[EBufW6laDDt[ZRpd2RuIFnDOVA:Oi5{Mt88US=>	NWrEOIFVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyNlM1PjBpPkOxNlI{PDZyPD;hQi=>
C8166	M{L1XWFvfGm4aYLhcEBie3OjeR?=		NF:xNIU4OiCqcoO=	MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDITXYyKDOEIHnu[oVkfGWmIHnuJIh2dWGwIFO4NVY3KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gd5lv[3m2aXHsJINmdGxiZn;ycYF1cW:wIHnuZ5Vj[XSnZDDmc5IhPzJiaILzMEBGSzVyPUCuN:69VQ>?	MnS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF\|MUCxNVUoRjNzM{GwNVE2RC:jPh?=
MT4	NUi5cGdUSW62aY\pdoFtKGG\|c3H5		MkTaOUBl[Xm\|	MlvzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\yC{ZYPpd5RidnRiSFnWMVEhcGG{Yn;ybY5oKHKndnXyd4UhfHKjboPjdolxfGG\|ZTDGNlI4VC:YMUC2RUBld3WkbHWgcZV1[W62IHnu[oVkfGWmIHnuJIh2dWGwIF3UOEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBqdmO3YnH0[YQh\m:{IEWg[IF6eyCkeTDNWHQh[XO\|YYmsJGVEPTB;MT65Nu69VQ>?	MmrtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF2M{SwN\|koRjNzNEO0NFM6RC:jPh?=
MT4	MVrBcpRqfmm{YXygZZN{[Xl?		M3;ZdFUh\GG7cx?=	NH75R\|NCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBlenWpIILld4l{fGGwdDDITXYuOSCqYYLic5JqdmdicnX2[ZJ{\SC2cnHud4NzcXC2YYPlJGwyODCLIH31eIFvfCCrbn\lZ5Rm\CCrbjDoeY1idiCPVESgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgbY5kfWKjdHXkJIZweiB3IHThfZMh[nliTWTUJIF{e2G7LDDFR\|UxRTNwMUVOwG0>	NFHBeoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUSzOFA{QSd-M{G0N\|QxOzl:L3G+
MT4	NVTDXZlPSW62aY\pdoFtKGG\|c3H5		NEPBd\|Y2KGSjeYO=	M17tU2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIRzfWdicnXzbZN1[W62IFjJWk0yKGijcnLvdolv\yC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgSVE{QEtibYX0ZY51KGmwZnXjeIVlKGmwIHj1cYFvKE2WNDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDpcoN2[mG2ZXSg[o9zKDViZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:Oy53ON88US=>	M2HndVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNEO0NFM6Lz5\|MUSzOFA{QTxxYU6=
MT4	NGLmNo1CdnSrdnnyZYwh[XO\|YYm=		MYS1JIRigXN?	M2rLcWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIRzfWdicnXzbZN1[W62IFjJWk0yKGijcnLvdolv\yC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgT\|ExO05ibYX0ZY51KGmwZnXjeIVlKGmwIHj1cYFvKE2WNDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDpcoN2[mG2ZXSg[o9zKDViZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:Oy55zszN	M3zxTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNEO0NFM6Lz5\|MUSzOFA{QTxxYU6=
MT4	MUjBcpRqfmm{YXygZZN{[Xl?		MUS1JIRigXN?	M4HkSGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXi1zIEPCJIlv\mWldHXkJIlvKGi3bXHuJG1VPCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCrbnP1ZoF1\WRiZn;yJFUh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9N{45QM7:TR?=	NIHCcog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUSzOFA{QSd-M{G0N\|QxOzl:L3G+
MT4	M1XSfGFvfGm4aYLhcEBie3OjeR?=		MkDnOUBl[Xm\|	M2PvRmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIRzfWdicnXzbZN1[W62IFjJWk0yKGijcnLvdolv\yC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgXVE5QExibYX0ZY51KGmwZnXjeIVlKGmwIHj1cYFvKE2WNDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDpcoN2[mG2ZXSg[o9zKDViZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:PC52Nd88US=>	M2KxTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNEO0NFM6Lz5\|MUSzOFA{QTxxYU6=
MT4	Mnv0RY51cX[rcnHsJIF{e2G7		M1jzd\|Uh\GG7cx?=	NVfMS2ZuSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\HK3ZzDy[ZNqe3SjboSgTGlXNTFiaHHyZo9zcW6pIILleoVze2VidILhcpNkemmydHHz[UB[OThzQzDteZRidnRiaX7m[YN1\WRiaX6gbJVu[W5iTWS0JINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIlv[3WkYYTl[EBnd3JiNTDkZZl{KGK7IF3UWEBie3OjeTygSWM2OD12LkW0{txO	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTR\|NECzPUc,OzF2M{SwN\|k9N2F-
MT4	MYHBcpRqfmm{YXygZZN{[Xl?		NHfT[pI2KGSjeYO=	NW\0b5JUSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh\HK3ZzDy[ZNqe3SjboSgTGlXNTFiUlXTNFU3KGijcnLvdolv\yC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgT\|ExO05xWUG4NWMh\G:3YnzlJI12fGGwdDDpcoZm[3SnZDDpckBpfW2jbjDNWFQh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5QhcW6ldXLheIVlKG[xcjC1JIRigXNiYomgUXRVKGG\|c3H5MEBGSzVyPUWuOVTPxE1?	M3O4ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNEO0NFM6Lz5\|MUSzOFA{QTxxYU6=
PBMC	NU\ZS5AxSW62aY\pdoFtKGG\|c3H5			MkjKRY51cX[rcnHsJIFkfGm4aYT5JIlvKFCETTDj[YxteyCneIDy[ZN{\WRiYYOgTWM2OCxiSVO1NF0xNjByMt88US=>	M1TJfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1OS9pPlPoSW1DVDxxYU6=
HepG2.2.15	NVuybnF4SW62aY\pdoFtKGG\|c3H5			MoLQRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbIVx[XSrdHnzJGIhfmm{dYOgbY4hcHWvYX6gbIVx[XSxbXGgZ4VtdCCuaX7lJEgzNjJwMUWgZ4VtdHNrLDDFR\|UxRTBwMEJOwG0>	NF\YRXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDFxJ{7DbGVOSkx:L3G+
HepG2.2.15	MWPGeY5kfGmxbjDhd5NigQ>?			M37h[GVn\mWldHn2[UBkd26lZX70doF1cW:wIH7lZ4V{e2G{eTD0c{Bl\WO{ZXHz[UBmgHS{YXPlcIx2dGG{IFjldIF1cXSrczDCJJZqenW\|IFTORUBt\X[nbIOgZpkhPTBnIHnuJIh2dWGwIHjldIF1d2KuYYP0c41iKGOnbHygcIlv\SBqMj6yMlE2KGOnbHzzLUBqdiC4aYTyc{whTUN3ME2wMlA{QM7:TR?=	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFEwLz6FaFXNRmw9N2F-
PBMC	NYqzeFlCTnWwY4Tpc44h[XO\|YYm=			M3rvZmNwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IHn0d{BidnSrLVjJWkBi[3Srdnn0fUBi\2GrboP0JGhKXi1zIFzBTUBqdiCqdX3hckBx\XKrcHjldoFtKGKub3;kJI1wdm:wdXPs[YFzKCiSQl2pJINmdGy\|LDDFR\|UxRTBwMEdOwG0>	NYG0V5V1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTRzLze+R4hGVUKOPD;hQi=>
HepG2.2.15	M2[4TGZ2dmO2aX;uJIF{e2G7			MoTlSYZn\WO2aY\lJINwdmOnboTyZZRqd25ibnXj[ZN{[XK7IITvJIRm[3KnYYPlJIV5fHKjY3XscJVt[XJiSHXwZZRqfGm\|IFKgeolzfXNiRF7BJIxmfmWuczDifUA6OCViaX6gbJVu[W5iaHXwZZRw[myjc4TvcYEh[2WubDDsbY5mKCh{LkKuNVUh[2WubIOpJIlvKH[rdILvMEBGSzlyPUCuNVbPxE1?	NVXLNnZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTRzLze+R4hGVUKOPD;hQi=>
HepG2.2.15	M3\C[WZ2dmO2aX;uJIF{e2G7			MUDU[ZN1\WRiZn;yJJRp\SCnZn\lZ5RqfmViY3;uZ4VvfHKjdHnvckBz\XG3aYLl[EB1dyCrbnjpZol1KEiEVjDpckBJ\XCJMj6yMlE2KGi3bXHuJIxqfmW{IHPlcIx{NCCHQ{WwQVAvOs7:TR?=	NYj1SWI5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTRzLze+R4hGVUKOPD;hQi=>
PBMC	MlLTRY51cX[rcnHsJIF{e2G7			NH3zTIZCdnSrdnnyZYwh[WO2aY\peJkhcW5iUFLNJINmdGy\|LDDJR\|UxRTBwMkJOwG0>	MmjvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQyNyd-Q3jFUWJNRC:jPh?=
PBMC	NIPuSIRCdnSrdnnyZYwh[XO\|YYm=			MXjBcpRqfmm{YXygZYN1cX[rdImgbY4hWEKPIHPlcIx{KGW6cILld5Nm\CCjczDJR\|UxNCCLQ{WwQVAvOjIQvF2=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFEwLz6FaFXNRmw9N2F-
MT-4	MnfBRY51cX[rcnHsJIF{e2G7			NF:2WoRCdnSrdnnyZYwh[WO2aY\peJkhcW5iTWStOEBk\WyuczygTWM2OD1yLkO3{txO	MnHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQyNyd-Q3jFUWJNRC:jPh?=
MT-4	NFPpfllCdnSrdnnyZYwh[XO\|YYm=			M3zWSWFvfGm4aYLhcEBi[3Srdnn0fUBqdiCPVD20JINmdGy\|IHX4dJJme3OnZDDhd{BKSzVyLDDJR\|UxRTBwM{hOwG0>	M{fFdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1OS9pPlPoSW1DVDxxYU6=
MT-4	M3nmbmFvfGm4aYLhcEBie3OjeR?=			MWTBcpRqfmm{YXygZYN1cX[rdImgbY4hVVRvNDDj[YxteyCneIDy[ZN{\WRiYYOgTWM2OCxiSVO1NF0xNjZzzszN	M2C0bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1OS9pPlPoSW1DVDxxYU6=
MT-4	NIP5d5VHfW6ldHnvckBie3OjeR?=			MXjDc41xd3WwZDD3ZZMhfGW\|dHXkJIZweiCrdIOgZY51cS2KSW[gZYN1cX[rdImgbY4h[WO3dHXsfUBqdm[nY4Tl[EBOXC12IHPlcIx{NCCHQ{WwQVfPxE1?	Mk\wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQyNyd-Q3jFUWJNRC:jPh?=

... Click to View More Cell Line Experimental Data

Protocol

References

Solubility (25°C)

In vitro	DMSO	46 mg/mL (200.64 mM)
	Water	46 mg/mL (200.64 mM)
	Ethanol	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Lamivudine (BCH-189) SDF

Molecular Weight	229.26
Formula	C₈H₁₁N₃O₃S
CAS No.	134678-17-4
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	GR109714X
Smiles	C1C(OC(S1)CO)N2C=CC(=NC2=O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04133012	Recruiting	Other: Samplings	HIV-1 Infection	ANRS Emerging Infectious Diseases\|ViiV Healthcare	February 10 2020	Not Applicable
NCT03869944	Recruiting	Drug: Lamivudine Oral Solution	HIV-1	ANRS Emerging Infectious Diseases\|Institut National de la Santé Et de la Recherche Médicale France\|Centre Muraz	December 4 2019	Phase 2
NCT03870438	Recruiting	Drug: Lamivudine Oral Solution	HIV-1	ANRS Emerging Infectious Diseases\|University Teaching Hospital Lusaka Zambia\|Centre Muraz\|Institut National de la Santé Et de la Recherche Médicale France\|University of Bergen	December 14 2019	Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Reverse Transcriptase Signaling Pathway Map

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Lamivudine (BCH-189)