Lamivudine

Catalog No.S1706 Synonyms: GR109714X

Lamivudine  Chemical Structure

Molecular Weight(MW): 229.26

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
USD 117 In stock
USD 187 In stock
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Cited by 1 Publication

1 Customer Review

  • The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.

    Oncotarget, 2017, 8(15):24694-24705. Lamivudine purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.
Targets
Reverse transcriptase [1]
In vitro

Lamivudine’s anti- HBV activity, like its anti-HIV activity, has been shown to depend on the ability of LMV-TP to serve as both substrate and inhibitor of the DNA- and RNA-dependent polymerase activities of the HBV P gene product. Lamivudine owes its activity to the remarkably broad substrate specificity of deoxycytidine kinase and the unusual substrate preference of the HBV polymerases for dNTPs with the unnatural L-conformation, whereas the anti-HBV activity of PCV appears to depend on several factors including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity) by key cellular enzymes, the long intracellular half-life of PCV-TP and the ability of PCV-TP to inhibit the HBV RT priming reaction as well as RT and DNA polymerase activity. [1] Lamivudine and Penciclovir inhibits duck hepatitis B virus (DHBV) replication to a comparable extent when used alone, and in combination, the two nucleoside analogs acts synergistically over a wide range of clinically relevant concentrations. Lamivudine combined with Penciclovir is more effective in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV than either drug alone. [2] Lamivudine inhibits p24 antigen production by HIV-I in PBMC, with ED50s ranging from 0.07 μM to 0.2 μM. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
2.2.15 cells NETZR3pHfW6ldHnvckBie3OjeR?= MXXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZBifGm2aYOgRkB3cXK3czCoTGJXMSCrbjCyMlIvOTViY3XscJMtKEWFNUC9NE4xODhizszN NGHQTHIyOTB3Mke5OS=>
PBMC cells NGPiNHhHfW6ldHnvckBie3OjeR?= MlraSYZn\WO2aY\lJINwdmOnboTyZZRqd25idH:gbY5pcWKrdDDITXYuOSCOQVmgZ5l1d3CjdHjpZ4l1gSCrbjDQRm1EKGOnbHzzJJdieyCmZYTldo1qdmWmIHnuJJZqfHKxLDDFR|UxRTBwMEGxOkDPxE1? MVixOFk4OTh7OB?=
human MT2 cells NWj6NpY2TnWwY4Tpc44h[XO|YYm= NYPkZmJTPSCmYYnz M{XNeWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFAvODB3IF3PTUB4cWymIIT5dIUhUEmYMTDOUFQuOyCrbn\lZ5Rm\CCrbjDoeY1idiCPVEKgZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhPSCmYYnzJIJ6KFKWIGPQRUwhTUN3ME2wMlA1KM7:TR?= MoTUNVg{OTZ3MkG=
human H9 cells M2P2emZ2dmO2aX;uJIF{e2G7 NGS3PIhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIEPCJIlvKGi3bXHuJGg6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCkeTDmc5Ju[Xqjbj3iZZNm\CClb372[Y51cW:wYXygZ49td3KrbXX0dolkKHSnY3jubZF2\SxiRVO1NF0xNjB4IN88US=> MofKNVE1OzByMUm=
human HuH7 cells NEi2bIJEgXSxdH;4bYNqfHliYYPzZZk> MVS0JIRigXN? M{jZRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2UDdiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JI5mfXS{YXygdoVlKGS7ZTD1dJRic2ViYYPzZZktKEOFNUC9NE4yKM7:TR?= MoPJNlE{OzN3M{W=
MT-4 cell NYfLe21XTnWwY4Tpc44h[XO|YYm= M2nqRWNwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDzfY51cWOjIH\vdo1ifGmxbjDifUA2OCViaX6gTGlXNTFiaX7m[YN1\WRiTWStOEBk\WyuczygTWM2OD1yLkGg{txO M{XjdFgxOzV2Mkm=
HepG2.2.15 cells NFrOXmpHfW6ldHnvckBie3OjeR?= NIqwcXdG\m[nY4TpeoUh[2:wY3XueJJifGmxbjD0c{BqdmirYnn0JIhmeGG2aYTpd{BDKH[rcoXzJIN6fG:yYYTobYNqfHliaX6gTIVxTzJwMj6xOUBk\WyuczD3ZZMh\GW2ZYLtbY5m\CCrbjD2bZRzdyxiRVO1NF0xNjJizszN MXGxOFk4OTh7OB?=
CEM-SS cells NX\icpd6TnWwY4Tpc44h[XO|YYm= NYrzfWNmSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYLUGgd5VjfHmyZTCzRkBqdm[nY4Tl[EBqdiCFRV2tV3Mh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB4IHThfZMh[nliWGTUJIF{e2G7LDDFR|UxRTBwMjFOwG0> M3exSFIzQDV6MEm3
human HeLa P4/R5 cells M2XaNmZ2dmO2aX;uJIF{e2G7 NX7Cd|hFSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDpcoZm[3SnZDDpckBpfW2jbjDI[WxiKFB2L2K1JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25uIFnDOVA:OC55ODFOwG0> NILxXXcyQTV7Nki4OS=>
HEK293 cells MnzNSpVv[3Srb36gZZN{[Xl? MXK3NkBp MYLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKHO3YoT5dIUhTCCrc3;sZZRmKDhiaX7m[YN1\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgdoVxdGmlYYTpc44h[W[2ZYKgO|IhcHK|LDDFR|UxRTNwMkWg{txO M1XI[FIxOzB6M{e3
MDCK2 cells NIHHVm9HfW6ldHnvckBie3OjeR?= NHTZc3EyOCEQvF2= MnPMTY5pcWKrdHnvckBw\iCqdX3hckBOWlB|IHX4dJJme3OnZDDpckBOTEONMjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IFPNSkBndHWxcnXzZ4Vv[2ViYYSgNVAhfU1iYomgR21HTEFiYYPzZZk> MWKxO|E4OjNzMR?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 46 mg/mL (200.64 mM)
Water 46 mg/mL (200.64 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 229.26
Formula

C8H11N3O3S

CAS No. 134678-17-4
Storage powder
in solvent
Synonyms GR109714X

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04034862 Not yet recruiting Drug: Treatment simplification (dolutegravir lamivudine) HIV Infections University of Liege October 1 2019 Phase 3
NCT03870438 Not yet recruiting Drug: Lamivudine Oral Solution HIV-1 French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|University Teaching Hospital Lusaka Zambia|Centre Muraz|Institut National de la Santé Et de la Recherche Médicale France|University of Bergen August 2019 Phase 3
NCT03869944 Not yet recruiting Drug: Lamivudine Oral Solution HIV-1 French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Institut National de la Santé Et de la Recherche Médicale France|Centre Muraz May 2019 Phase 2
NCT03205566 Unknown status Drug: Raltegravir 400Mg Tab|Drug: Lamivudine 150Mg Tablet Hiv Guy''s and St Thomas'' NHS Foundation Trust July 2017 Phase 4
NCT02708342 Completed -- HIV Ospedale San Raffaele|Merck Sharp & Dohme Corp. April 2016 --
NCT02634073 Completed Drug: Lamivudine|Drug: Sorbitol Infection Human Immunodeficiency Virus ViiV Healthcare|GlaxoSmithKline January 1 2016 Phase 4

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID