Lamivudine

For research use only.

Catalog No.S1706 Synonyms: GR109714X

4 publications

Lamivudine  Chemical Structure

Molecular Weight(MW): 229.26

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 130 In stock
USD 60 In stock
USD 117 In stock
USD 187 In stock
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Selleck's Lamivudine has been cited by 4 publications

1 Customer Review

  • The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.

    Oncotarget, 2017, 8(15):24694-24705. Lamivudine purchased from Selleck.

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Biological Activity

Description Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.
Targets
Reverse transcriptase [1]
In vitro

Lamivudine’s anti- HBV activity, like its anti-HIV activity, has been shown to depend on the ability of LMV-TP to serve as both substrate and inhibitor of the DNA- and RNA-dependent polymerase activities of the HBV P gene product. Lamivudine owes its activity to the remarkably broad substrate specificity of deoxycytidine kinase and the unusual substrate preference of the HBV polymerases for dNTPs with the unnatural L-conformation, whereas the anti-HBV activity of PCV appears to depend on several factors including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity) by key cellular enzymes, the long intracellular half-life of PCV-TP and the ability of PCV-TP to inhibit the HBV RT priming reaction as well as RT and DNA polymerase activity. [1] Lamivudine and Penciclovir inhibits duck hepatitis B virus (DHBV) replication to a comparable extent when used alone, and in combination, the two nucleoside analogs acts synergistically over a wide range of clinically relevant concentrations. Lamivudine combined with Penciclovir is more effective in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV than either drug alone. [2] Lamivudine inhibits p24 antigen production by HIV-I in PBMC, with ED50s ranging from 0.07 μM to 0.2 μM. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
2.2.15 cells M3nKU2Z2dmO2aX;uJIF{e2G7 NXzVdW5pSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGWyYYTpeIl{KEJidnnyeZMhMEiEVjmgbY4hOi5{LkG1JINmdGy|LDDFR|UxRTBwMEC4JO69VQ>? M1zYRlEyODV{N{m1
PBMC cells NXfnfVFOTnWwY4Tpc44h[XO|YYm= NUjlS4J4TW[oZXP0bZZmKGOxbnPlcpRz[XSrb36geI8hcW6qaXLpeEBJUVZvMTDMRWkh[3m2b4DheIhq[2m2eTDpckBRSk2FIHPlcIx{KHejczDk[ZRmem2rbnXkJIlvKH[rdILvMEBGSzVyPUCuNFEyPiEQvF2= NHz1OY0yPDl5MUi5PC=>
human MT2 cells M1zJT2Z2dmO2aX;uJIF{e2G7 NGnUOnA2KGSjeYO= NXW0NnFqSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yMEWgUW9KKHerbHSgeJlx\SCKSW[xJG5NPC1|IHnu[oVkfGWmIHnuJIh2dWGwIF3UNkBk\WyuczDt[YF{fXKnZDDh[pRmeiB3IHThfZMh[nliUmSgV3BCNCCHQ{WwQVAvODRizszN M1r4[|E5OzF4NUKx
human H9 cells M{f2b2Z2dmO2aX;uJIF{e2G7 NX3jXIZxSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTCzRkBqdiCqdX3hckBJQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYomg[o9zdWG8YX6tZoF{\WRiY3;ueoVvfGmxbnHsJINwdG:{aX3leJJq[yC2ZXPocolyfWVuIFXDOVA:OC5yNjFOwG0> M4fUbFEyPDNyMEG5
human HuH7 cells Moi0R5l1d3SxeHnjbZR6KGG|c3H5 MlLIOEBl[Xm| NHPVXJdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfUh5IHPlcIx{KGGodHXyJFQh\GG7czDifUBv\XW2cnHsJJJm\CCmeXWgeZB1[WunIHHzd4F6NCCFQ{WwQVAvOSEQvF2= MXmyNVM{OzV|NR?=
MT-4 cell MUfGeY5kfGmxbjDhd5NigQ>? MUnDc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIHnubIljcXRic4nueIlk[SCob4LtZZRqd25iYomgOVAmKGmwIFjJWk0yKGmwZnXjeIVlKE2WLUSgZ4VtdHNuIFnDOVA:OC5zIN88US=> MnLxPFA{PTR{OR?=
HepG2.2.15 cells NUnaTFJjTnWwY4Tpc44h[XO|YYm= MVfF[oZm[3SrdnWgZ49v[2WwdILheIlwdiC2bzDpcohq[mm2IHjldIF1cXSrczDCJJZqenW|IHP5eI9x[XSqaXPpeJkhcW5iSHXwS|IvOi5zNTDj[YxteyC5YYOg[IV1\XKvaX7l[EBqdiC4aYTyc{whTUN3ME2wMlIh|ryP NI[xNokyPDl5MUi5PC=>
CEM-SS cells MUnGeY5kfGmxbjDhd5NigQ>? MmXwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXNTFic4XieJlx\SB|QjDpcoZm[3SnZDDpckBETU1vU2OgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA3KGSjeYOgZpkhYFSWIHHzd4F6NCCHQ{WwQVAvOiEQvF2= M2Pu[lIzQDV6MEm3
human HeLa P4/R5 cells Ml;0SpVv[3Srb36gZZN{[Xl? NGPlXW5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIHnu[oVkfGWmIHnuJIh2dWGwIFjlUIEhWDRxUkWgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdixiSVO1NF0xNjd6IN88US=> NG\tPFkyQTV7Nki4OS=>
HEK293 cells MVTGeY5kfGmxbjDhd5NigQ>? MXu3NkBp NH3ER4lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIIP1ZpR6eGViRDDpd49t[XSnIEigbY5n\WO2ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMhemWybHnjZZRqd25iYX\0[ZIhPzJiaILzMEBGSzVyPUOuNlUh|ryP NEjEUZIzODNyOEO3Oy=>
MDCK2 cells MXPGeY5kfGmxbjDhd5NigQ>? NILvcHMyOCEQvF2= M3OxV2lvcGmkaYTpc44hd2ZiaIXtZY4hVVKSMzDlfJBz\XO|ZXSgbY4hVUSFS{KgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDDUWYh\my3b4Lld4NmdmOnIHH0JFExKHWPIHL5JGNOTkSDIHHzd4F6 NED6PXYyPzF5MkOxNS=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 46 mg/mL (200.64 mM)
Water 46 mg/mL (200.64 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 229.26
Formula

C8H11N3O3S

CAS No. 134678-17-4
Storage powder
in solvent
Synonyms GR109714X
Smiles NC1=NC(=O)N(C=C1)C2CSC(CO)O2

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Dilution Calculator

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Molecular Weight Calculator

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03869944 Recruiting Drug: Lamivudine Oral Solution HIV-1 French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Institut National de la Santé Et de la Recherche Médicale France|Centre Muraz December 4 2019 Phase 2
NCT03870438 Recruiting Drug: Lamivudine Oral Solution HIV-1 French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|University Teaching Hospital Lusaka Zambia|Centre Muraz|Institut National de la Santé Et de la Recherche Médicale France|University of Bergen December 14 2019 Phase 3
NCT04133012 Not yet recruiting Other: Samplings HIV-1 Infection French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|ViiV Healthcare November 1 2019 Not Applicable
NCT04034862 Not yet recruiting Drug: Treatment simplification (dolutegravir lamivudine) HIV Infections University of Liege October 1 2019 Phase 3

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID