Tenofovir Alafenamide (GS-7340)
For research use only.
CAS No. 379270-37-8
Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
Selleck's Tenofovir Alafenamide (GS-7340) has been cited by 6 publications
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|Description||Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.|
GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM.  GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C.  the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. 
|In vivo||In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. |
|In vitro||DMSO||95 mg/mL (199.38 mM)|
|Ethanol||95 mg/mL (199.38 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04551573||Not yet recruiting||Drug: Rifapentine daily|Drug: Rifapentine weekly||Tuberculosis|Hiv||Yale University|Gilead Sciences||May 2021||Phase 4|
|NCT04530630||Recruiting||Drug: BIKTARVY 50Mg-200Mg-25Mg Tablet||HIV Infections|Renal Transplant Rejection||Weill Medical College of Cornell University|Gilead Sciences||November 9 2020||Phase 4|
|NCT03789968||Completed||Drug: bictegravir/emtricitabine/tenofovir alafenamide||HIV/AIDS||Thomas Jefferson University|University of Maryland College Park|Indiana University Health|The Brooklyn Hospital Center|University of Illinois at Chicago|Nova Southeastern University|University of California San Francisco||September 1 2019||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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