Tenofovir Alafenamide (GS-7340)
For research use only.
CAS No. 379270-37-8
Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
Purity & Quality Control
Choose Selective Reverse Transcriptase Inhibitors
|Description||Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.|
GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM.  GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C.  the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. 
|In vivo||In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. |
|In vitro||DMSO||95 mg/mL (199.38 mM)|
|Ethanol||95 mg/mL (199.38 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04530630||Not yet recruiting||Drug: BIKTARVY 50Mg-200Mg-25Mg Tablet||HIV Infections|Renal Transplant Rejection||Weill Medical College of Cornell University|Gilead Sciences||September 2020||Phase 3|
|NCT03789968||Enrolling by invitation||Drug: bictegravir/emtricitabine/tenofovir alafenamide||HIV/AIDS||Thomas Jefferson University|University of Maryland College Park|Indiana University Health|The Brooklyn Hospital Center|University of Illinois at Chicago|Nova Southeastern University|University of California San Francisco||September 1 2019||--|
|NCT03960645||Recruiting||Drug: B/F/TAF||HIV-1-infection||Gilead Sciences||June 28 2019||Phase 1|
|NCT02985996||Completed||Drug: Truvada|Drug: Genvoya||HIV Infections||Emory University|Centers for Disease Control and Prevention||February 6 2017||Phase 1|
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