Name: Tenofovir alafenamide fumarate
Brand: Selleck Chemicals
SKU: S4428
Rating: 5 (2 reviews)

Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

Tenofovir alafenamide fumarate Chemical Structure

CAS: 379270-38-9

Selleck's Tenofovir alafenamide fumarate has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.92%

99.92

Tenofovir alafenamide fumarate Related Products

Related Targets	HBV RT HIV RT RT	Click to Expand
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Signaling Pathway

Reverse Transcriptase Signaling Pathway

Choose Selective Reverse Transcriptase Inhibitors

Biological Activity

Description

Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

Targets

reverse transcriptase ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05652478	Recruiting	Metabolic Effects\|Weight Gain\|HIV\|Integrase Strand Transfer Inhibitors	National Institute of Allergy and Infectious Diseases (NIAID)\|National Institutes of Health Clinical Center (CC)	January 12 2024	Phase 2
NCT06104306	Recruiting	HIV-1-infection	Gilead Sciences	December 13 2023	Phase 4
NCT05583006	Recruiting	Patient Satisfaction\|Drug Adherence\|Efficacy Self\|Safety Issues	Taichung Veterans General Hospital\|Institute of Adherence to Medication	November 6 2023	--
NCT05924438	Recruiting	HIV-1-infection	Professor Francois Venter\|Africa Health Research Institute\|Merck Sharp & Dohme LLC\|University of Witwatersrand South Africa	November 8 2023	Phase 3

References

[1] Amanda K Gibson, et al. Ann Pharmacother. 2016 Nov;50(11):942-952.

Chemical Information & Solubility

Molecular Weight	592.54	Formula	C₂₅H₃₃N₆O₉P
CAS No.	379270-38-9	SDF	--
Smiles	CC(C)OC(=O)C(C)N[P](=O)(COC(C)C[N]1C=NC2=C(N)N=CN=C12)OC3=CC=CC=C3.OC(=O)\C=C\C(O)=O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (168.76 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : 10 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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