Tenofovir alafenamide fumarate

For research use only.

Catalog No.S4428 Synonyms: TAF fumarate, GS-7340 fumarate

2 publications

Tenofovir alafenamide fumarate Chemical Structure

CAS No. 379270-38-9

Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

Selleck's Tenofovir alafenamide fumarate has been cited by 2 publications

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Biological Activity

Description Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Targets
reverse transcriptase [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (168.76 mM)
Water 10 mg/mL (16.87 mM)
Ethanol '100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 592.54
Formula

C25H33N6O9P

CAS No. 379270-38-9
Storage powder
in solvent
Synonyms TAF fumarate, GS-7340 fumarate

In vivo Formulation Calculator (Clear solution)

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04993872 Not yet recruiting Drug: Biktarvy Tab HIV-infected Patient Kidney Transplant Recipient Institut de Médecine et d''Epidémiologie Appliquée - Fondation Internationale Léon M''Ba|LAMBERT ASSOUMOU/ UNITE 1136 INSERM|Sebastien GALLIEN/Henri Mondor University Hospital- Infectiology Department|THOMAS STEHL/ HENRI MONDOR HOSPITAL-Department of Nephrology October 18 2021 Phase 4
NCT04619082 Recruiting Drug: Tenofovir alafenamide Hepatitis B Reactivation Chiayi Christian Hospital|St. Martin De Porress Hospital|Dalin Tzu Chi General Hospital|National Taiwan University Hospital Yun-Lin Branch|Chi Mei Medical Hospital June 15 2021 Phase 4
NCT04201808 Recruiting Drug: Tenofovir Alafenamide 25 MG Hepatitis B Chronic New Discovery LLC|Beijing Ditan Hospital May 1 2021 Phase 4
NCT04551573 Not yet recruiting Drug: Rifapentine daily|Drug: Rifapentine weekly Tuberculosis|Hiv Yale University|Gilead Sciences May 2021 Phase 4

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID