Tenofovir alafenamide hemifumarate
For research use only.
Catalog No.S4427 Synonyms: TAF hemifumarate, GS-7340 hemifumarate
CAS No. 1392275-56-7
Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Purity & Quality Control
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|Description||Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.|
|In vitro||DMSO||100 mg/mL (93.54 mM)|
|Water||50 mg/mL (46.77 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||TAF hemifumarate, GS-7340 hemifumarate|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).
Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04993872||Not yet recruiting||Drug: Biktarvy Tab||HIV-infected Patient Kidney Transplant Recipient||Institut de Médecine et d''Epidémiologie Appliquée - Fondation Internationale Léon M''Ba|LAMBERT ASSOUMOU/ UNITE 1136 INSERM|Sebastien GALLIEN/Henri Mondor University Hospital- Infectiology Department|THOMAS STEHL/ HENRI MONDOR HOSPITAL-Department of Nephrology||October 18 2021||Phase 4|
|NCT04619082||Recruiting||Drug: Tenofovir alafenamide||Hepatitis B Reactivation||Chiayi Christian Hospital|St. Martin De Porress Hospital|Dalin Tzu Chi General Hospital|National Taiwan University Hospital Yun-Lin Branch|Chi Mei Medical Hospital||June 15 2021||Phase 4|
|NCT04201808||Recruiting||Drug: Tenofovir Alafenamide 25 MG||Hepatitis B Chronic||New Discovery LLC|Beijing Ditan Hospital||May 1 2021||Phase 4|
|NCT04551573||Not yet recruiting||Drug: Rifapentine daily|Drug: Rifapentine weekly||Tuberculosis|Hiv||Yale University|Gilead Sciences||May 2021||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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