Tenofovir alafenamide hemifumarate

Catalog No.S4427 Synonyms: TAF hemifumarate, GS-7340 hemifumarate

For research use only.

Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

Tenofovir alafenamide hemifumarate Chemical Structure

CAS No. 1392275-56-7

Selleck's Tenofovir alafenamide hemifumarate has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Targets
reverse transcriptase [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 1069
Formula

C46H62N12O14P2

CAS No. 1392275-56-7
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05140954 Not yet recruiting Drug: co-formulated 25mg TAF/ 200mg FTC HIV Infections University of Washington|Kenya Medical Research Institute|University of Colorado Denver|Gilead Sciences September 2022 Phase 2|Phase 3
NCT05195450 Recruiting Drug: Tenofovir alafenamide fumarate Non-cirrhotic Chronic Hepatitis B Institute of Liver and Biliary Sciences India February 23 2022 Not Applicable
NCT05222945 Not yet recruiting Other: Biopsies and bloood samplings HIV-1-infection ANRS Emerging Infectious Diseases|Gilead Sciences February 1 2022 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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