Piezo Channel

Other Cytoskeletal Signaling Related Inhibitors

HSP Kinesin Microtubule Associated Integrin PAK Dynamin MLCK TACC3 Gap-Junction Actin

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S6678	Yoda1	Yoda1 acts as an agonist for both human and mouse Piezo1(EC50 of 17.1 and 26.6 μM for mouse and human). Yoda1 activates purified Piezo1 channels in the absence of other cellular components.	Theranostics, 2025, 15(14):6901-6918 Ocul Surf, 2025, 36:56-68 Invest Ophthalmol Vis Sci, 2025, 66(1):33
S2953	Dooku1	Dooku1 is an analog of Yoda1 with antagonist activity against mechanosensitive Piezo1 channel. This compound inhibits 2 μM Yoda1-induced Ca²⁺-entry with IC50 of 1.3 μM in HEK 293 cells and 1.5 μM in HUVECs, respectively.	Sci Adv, 2023, 9(22):eadg0478

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S6678

Yoda1

Yoda1 acts as an agonist for both human and mouse Piezo1(EC50 of 17.1 and 26.6 μM for mouse and human). Yoda1 activates purified Piezo1 channels in the absence of other cellular components.

Theranostics, 2025, 15(14):6901-6918

Ocul Surf, 2025, 36:56-68

Invest Ophthalmol Vis Sci, 2025, 66(1):33

S2953

Dooku1

Dooku1 is an analog of Yoda1 with antagonist activity against mechanosensitive Piezo1 channel. This compound inhibits 2 μM Yoda1-induced Ca²⁺-entry with IC50 of 1.3 μM in HEK 293 cells and 1.5 μM in HUVECs, respectively.

Sci Adv, 2023, 9(22):eadg0478