Home Cytoskeletal Signaling Integrin inhibitor A-205804

A-205804

Catalog No.S2885

For research use only.

A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.

A-205804 Chemical Structure

CAS No. 251992-66-2

Selleck's A-205804 has been cited by 4 Publications

2 Customer Reviews

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Biological Activity

Description A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
Targets
E-selectin [1] ICAM-1 [1]
20 nM 25 nM
In vitro

A-205804 selectively inhibits the surface expression of the cell adhesion molecules ICAM-1 and E-selectin in human endothelial cells. A-205804 inhibites the IL-1β-induced expression of E-selectin (IC50 = 20 nM) and ICAM-1 (IC50 = 10 nM) with essentially the same level of potency as that for TNFα-induced expression. For reasons which are unclear, the ability of A-205804 to inhibit PMA-induced E-selectin expression is significantly reduced (IC50 > 1000 nM), but A-205804 is a potent inhibitor of ICAM-1 expression (IC50 = 40 nM) using this protein-kinase C-activating agent. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

 DMSO 60 mg/mL
(199.73 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 300.4
Formula

C15H12N2OS2
CAS No. 251992-66-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC=C(C=C1)SC2=C3C=C(SC3=CN=C2)C(=O)N

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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