For research use only.

Catalog No.S2885

3 publications

A-205804 Chemical Structure

CAS No. 251992-66-2

A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.

Selleck's A-205804 has been cited by 3 publications

2 Customer Reviews

  • The effect of rhICAM-1 or inhibitor A-205804 on hepsin or CtsD transfected MCF-7 cells was detected. The level of E-cadherin, claudin-1, N-cadherin, vimentin and Snail1 was analyzed by western blot.

    Cancer Lett, 2018, 438:105-115. A-205804 purchased from Selleck.

    MDA-MB-231 cells transfected with ICAM-1-specific siRNAs or treated for 12 h with A-205804 at the indicated concentrations were subjected to immunoblotting with indicated antibodies. Densitometric data (fold) were shown below each group.

    Acta Pharmacologica Sinica, 2018, 39: 1-12 . A-205804 purchased from Selleck.

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Biological Activity

Description A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
E-selectin [1] ICAM-1 [1]
20 nM 25 nM
In vitro

A-205804 selectively inhibits the surface expression of the cell adhesion molecules ICAM-1 and E-selectin in human endothelial cells. A-205804 inhibites the IL-1β-induced expression of E-selectin (IC50 = 20 nM) and ICAM-1 (IC50 = 10 nM) with essentially the same level of potency as that for TNFα-induced expression. For reasons which are unclear, the ability of A-205804 to inhibit PMA-induced E-selectin expression is significantly reduced (IC50 > 1000 nM), but A-205804 is a potent inhibitor of ICAM-1 expression (IC50 = 40 nM) using this protein-kinase C-activating agent. [2]


Solubility (25°C)

In vitro DMSO 60 mg/mL (199.73 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.4


CAS No. 251992-66-2
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CC=C(C=C1)SC2=C3C=C(SC3=CN=C2)C(=O)N

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Integrin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID