A-205804
Catalog No.S2885
Molecular Weight(MW): 300.4
A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
2 Customer Reviews
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The effect of rhICAM-1 or inhibitor A-205804 on hepsin or CtsD transfected MCF-7 cells was detected. The level of E-cadherin, claudin-1, N-cadherin, vimentin and Snail1 was analyzed by western blot.
Cancer Lett, 2018, 438:105-115. A-205804 purchased from Selleck.
MDA-MB-231 cells transfected with ICAM-1-specific siRNAs or treated for 12 h with A-205804 at the indicated concentrations were subjected to immunoblotting with indicated antibodies. Densitometric data (fold) were shown below each group.
Acta Pharmacologica Sinica, 2018, 39: 1-12 . A-205804 purchased from Selleck.
Purity & Quality Control
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Biological Activity
| Description | A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively. | ||||
|---|---|---|---|---|---|
| Targets |
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| In vitro |
A-205804 selectively inhibits the surface expression of the cell adhesion molecules ICAM-1 and E-selectin in human endothelial cells. A-205804 inhibites the IL-1β-induced expression of E-selectin (IC50 = 20 nM) and ICAM-1 (IC50 = 10 nM) with essentially the same level of potency as that for TNFα-induced expression. For reasons which are unclear, the ability of A-205804 to inhibit PMA-induced E-selectin expression is significantly reduced (IC50 > 1000 nM), but A-205804 is a potent inhibitor of ICAM-1 expression (IC50 = 40 nM) using this protein-kinase C-activating agent. [2] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 60 mg/mL (199.73 mM) |
|---|---|---|
| Water | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 300.4 |
|---|---|
| Formula | C15H12N2OS2 |
| CAS No. | 251992-66-2 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
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