RGD (Arg-Gly-Asp) Peptides
For research use only.
CAS No. 99896-85-2
RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
Selleck's RGD (Arg-Gly-Asp) Peptides has been cited by 11 publications
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Observation of actin cytoskeleton and nucleus of MC3T3-E1 cells cultured in the presence of different inhibitors (Control, EDTA, RGD, MAB1998, IgG and Heparin) after 24 hours of incubation.
Int J Nanomedicine, 2018, 13:7657-7667. RGD (Arg-Gly-Asp) Peptides purchased from Selleck.
Targeting the ECM/integrin signaling inhibited the activation of astrocytes in the hippocampus of epileptic rats. (A) Representative fluorescence micrographs of GFAP expression in the hippocampus of epilepsy mice with or without RGD treatment. Scale bar = 50 μm. (B) Western blot analysis of GFAP protein level in the hippocampus of epilepsy mice with or without RGD treatment (n = 3). Protein bands were quantified by densitometry and normalized to the level of GAPDH. Data represent mean ± SEM. *P < 0.05, **P < 0.01.
Neuroscience, 2019, 396:187-199. RGD (Arg-Gly-Asp) Peptides purchased from Selleck.
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|Description||RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.|
The RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, and cell surface proteins, and nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands. The RGD peptides and mimics can be used to probe integrin functions in various biological systems. Drug design based on the RGD structure may provide new treatments for diseases such as thrombosis, osteoporosis, and cancer.  RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing.  The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins.  In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion. 
-  Ruoslahti E, et al. Annu Rev Cell Dev Biol, 1996, 12, 697-715.
-  Buckley CD, et al. Nature, 1999, 397(6719), 534-539.
-  Meredith JE Jr, et al. Trends Cell Biol, 1997, 7(4), 146-150.
|In vitro||Water||12 mg/mL (34.64 mM)|
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In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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