RGD (Arg-Gly-Asp) Peptides

For research use only.

Catalog No.S8008

10 publications

RGD (Arg-Gly-Asp) Peptides Chemical Structure

Molecular Weight(MW): 346.34

RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.

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Selleck's RGD (Arg-Gly-Asp) Peptides has been cited by 10 publications

3 Customer Reviews

  • Observation of actin cytoskeleton and nucleus of MC3T3-E1 cells cultured in the presence of different inhibitors (Control, EDTA, RGD, MAB1998, IgG and Heparin) after 24 hours of incubation.

    Int J Nanomedicine, 2018, 13:7657-7667. RGD (Arg-Gly-Asp) Peptides purchased from Selleck.

    BC, aMPV/B F protein fusogenic activity was determined using syncytium formation and reporter gene assays. RGE peptides (80 μM) were used as the control.

    J Biol Chem, 2016, 291(28):14815-25.. RGD (Arg-Gly-Asp) Peptides purchased from Selleck.

  • Targeting the ECM/integrin signaling inhibited the activation of astrocytes in the hippocampus of epileptic rats. (A) Representative fluorescence micrographs of GFAP expression in the hippocampus of epilepsy mice with or without RGD treatment. Scale bar = 50 μm. (B) Western blot analysis of GFAP protein level in the hippocampus of epilepsy mice with or without RGD treatment (n = 3). Protein bands were quantified by densitometry and normalized to the level of GAPDH. Data represent mean ± SEM. *P < 0.05, **P < 0.01.

    Neuroscience, 2019, 396:187-199. RGD (Arg-Gly-Asp) Peptides purchased from Selleck.

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Choose Selective Integrin Inhibitors

Biological Activity

Description RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
Integrin [1]
In vitro

The RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, and cell surface proteins, and nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands. The RGD peptides and mimics can be used to probe integrin functions in various biological systems. Drug design based on the RGD structure may provide new treatments for diseases such as thrombosis, osteoporosis, and cancer. [1] RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. [2] The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. [3] In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion. [4]


Cell Research:


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  • Cell lines: HLE cell line
  • Concentrations: 0.1, 0.3, 1.0 and 2.0 mg/ml
  • Incubation Time: 90 min
  • Method:

    The cells were seeded at approximately 2.6 × 104 /well on each ECM-coated 24-well plate in the medium containing the monotype of GRGDSP RGD peptide at 0 (control), 0.1, 0.3, 1.0 and 2.0 mg/ml. After 90 min of incubation, the floating cells were removed by washing twice with Ca 2+ -Mg 2+ -free phosphate-buffered saline. Then the attached cells were dissociated with trypsin-EDTA solution. The number of cells attached at each concentration of peptide was counted using a hemocytometer. 

    (Only for Reference)

Solubility (25°C)

In vitro Water 12 mg/mL (34.64 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 346.34


CAS No. 99896-85-2
Storage powder
in solvent
Synonyms N/A
Smiles C(CC(C(=O)NCC(=O)NC(CC(=O)O)C(=O)O)N)CN=C(N)N

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Integrin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID