Thiotepa

Catalog No.S1775 Synonyms: Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide

For research use only.

Thiotepa (Thioplex, Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide) is an alkylating agent used to treat cancer.

Thiotepa Chemical Structure

CAS No. 52-24-4

Selleck's Thiotepa has been cited by 3 Publications

Purity & Quality Control

Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description Thiotepa (Thioplex, Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide) is an alkylating agent used to treat cancer.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 189.22
Formula

C6H12N3PS

CAS No. 52-24-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CN1P(=S)(N2CC2)N3CC3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05021770 Not yet recruiting Drug: Orelabrutinib|Drug: Thiotepa Refractory and Relapsed Primary CNS Lymphoma|PCNSL|Non Hodgkin Lymphoma Huiqiang Huang|Guangdong 999 Brain Hospital|Sun Yat-sen University December 2021 Phase 1|Phase 2
NCT03609840 Active not recruiting Drug: Thiotepa Hematologic Malignancies|Nonmalignant Diseases|Immune Deficiency|Hemoglobinopathies|Genetic Inborn Errors of Metabolism|Fanconi Anemia|Thalassemia|Sickle Cell Disease University of California San Francisco May 24 2017 --
NCT05167370 Terminated Drug: Amifostine Solid Tumors|Brain Tumors Children''s Hospital Medical Center Cincinnati December 13 2010 Phase 2
NCT01068301 Completed Drug: Plerixafor Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Chronic Myeloid Leukemia|Myelodysplastic Syndrome|Non-Hodgkin''s Lymphoma St. Jude Children''s Research Hospital|Genzyme a Sanofi Company May 2010 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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