Home Biosimilar Antibodies Protein Tyrosine Kinase HER2 Trastuzumab MMAE
For research use only. Not for use in humans.

Trastuzumab MMAE

Trastuzumab MMAE is an antibody-drug conjugate (ADC). It is composed of monomethyl auristatin E (MMAE) and trastuzumab conjugated via a Vc (Valine‐citrulline) linker. Trastuzumab MMAE has high affinity, specificity and anti-tumor activity in vitro.

Trastuzumab MMAE

CAS No.

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Quality Control

Batch: Purity: 99% Protein concentration: 9.889mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation HER2 Others
Canertinib (CI-1033) 48 EGFR
CP-724714 109
Sapitinib (AZD8931) 50 ErbB3,EGFR
CUDC-101 23 EGFR,HDAC,HDAC1
Mubritinib (TAK 165) 40
AEE788 (NVP-AEE788) 13 EGFR,c-Abl,FLT1
AC480 (BMS-599626) 10 HER1,HER4
TAK-285 4 EGFR/HER1,HER4,MEK1
Tyrphostin AG 879 3 Trk
Tuxobertinib (BDTX-189) 2 EGFR,RIPK2,BLK
Epertinib hydrochloride 0 EGFR,HER4
TAS0728 1
Tyrphostin AG-528 0 EGFR
SU5204 1 VEGFR-2
Pyrotinib dimaleate 4 EGFR
Poziotinib (NOV120101, HM781-36B) 35 HER1,HER4
HER2-Inhibitor-1 1
Zongertinib (BI 1810631) 1 EGFR-Ex20ins
Nordihydroguaiaretic acid (NDGA) 1 p300,IGF-1R,lipoxygenase
EGCG ((-)-Epigallocatechin Gallate) 42 FASN,EGFR,DNMT
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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Trastuzumab MMAE is an antibody-drug conjugate (ADC). It is composed of monomethyl auristatin E (MMAE) and trastuzumab conjugated via a Vc (Valine‐citrulline) linker. Trastuzumab MMAE has high affinity, specificity and anti-tumor activity in vitro.
References

Product Details

ADC antiody Trastuzumab
ADC linker Vc linker
ADC cytotoxin MMAE
Formulation 1xPBS
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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