Disitamab (Anti-ERBB2 / HER2 / CD340) HER2 antibody | Read Reviews & Product Use Citations

Disitamab (Anti-ERBB2 / HER2 / CD340) is a humanized monoclonal antibody targeting HER2. It can be used in the synthesis of antibody-drug conjugates (ADCs), Disitamab vedotin. It has antitumor and antineoplastic activities. MW :144.16 KD

Quality Control

Batch: A260601 Purity: 99% Protein concentration: 9.32mg/ml Endotoxin Level: ＜1EU/mg

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99

Specificity

Name	Citation	HER2	Others
Canertinib (CI-1033)	48	+++	EGFR
CP-724714	109	+++
Sapitinib (AZD8931)	50	++++	ErbB3,EGFR
CUDC-101	23	++	EGFR,HDAC,HDAC1
Mubritinib (TAK 165)	40	++++
AEE788 (NVP-AEE788)	13	++++	EGFR,c-Abl,FLT1
AC480 (BMS-599626)	10	++	HER1,HER4
TAK-285	4	++	EGFR/HER1,HER4,MEK1
Tyrphostin AG 879	3	+	Trk
Tuxobertinib (BDTX-189)	2	++++	EGFR,RIPK2,BLK
Epertinib hydrochloride	0	++++	EGFR,HER4
TAS0728	1	+++
Tyrphostin AG-528	0	+	EGFR
SU5204	1	+	VEGFR-2
Pyrotinib dimaleate	4	+	EGFR
Poziotinib (HM781-36B)	35	++++	HER1,HER4
HER2-Inhibitor-1	1	✔
Zongertinib	1	✔	EGFR-Ex20ins
Nordihydroguaiaretic acid (NDGA)	1	✔	p300,IGF-1R,lipoxygenase
EGCG ((-)-Epigallocatechin Gallate)	42	✔	FASN,EGFR,DNMT

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Disitamab (Anti-ERBB2 / HER2 / CD340) is a humanized monoclonal antibody targeting HER2. It can be used in the synthesis of antibody-drug conjugates (ADCs), Disitamab vedotin. It has antitumor and antineoplastic activities. MW :144.16 KD
References	[1] https://pubmed.ncbi.nlm.nih.gov/31877330/

Product Details

CAS No.	2185868-98-6
Molecular Weight	144.16
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.