For research use only. Not for use in humans.

Disitamab vedotin

Synonyms: RC-48, RC 480-ADC Cat.No.D4049 Purity:99.17%

Disitamab Vedotin (RC-48 ,RC 480-ADC) is an antibody-drug conjugate(ADC) composed of anti-[ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)] humanized monoclonal antibody, conjugated to monomethylauristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker. Disitamab Vedotin has the potential for use in solid tumors mainly in advanced breast cancer.

CAS No. 2136633-23-1

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1 Citation

17 Nobel Prize winners have used Selleck products

Shimon Sakaguchi

Nature Communications 2025,16, Article number:1325

David Baker

Dev Cell 2023, 58(20):2163-2180.e9.

David Julius

Cell 2017, 185-198.e16

Michael Houghton

Cell Chem Biol, 2020, 27(7):780-792.e5

Charles M. Rice

Cell 2018, 172(3):423-438.e25

Quality Control

Batch: D404901 Purity: 99.17% Protein concentration: 3.3mg/ml Endotoxin Level: ＜1EU/mg

99.17

Specificity

Name	Citation	HER2	Others
Canertinib (CI-1033)	48	+++	EGFR
CP-724714	109	+++
Sapitinib (AZD8931)	50	++++	ErbB3,EGFR
CUDC-101	23	++	EGFR,HDAC,HDAC1
Mubritinib (TAK 165)	40	++++
AEE788 (NVP-AEE788)	13	++++	EGFR,c-Abl,FLT1
AC480 (BMS-599626)	10	++	HER1,HER4
TAK-285	4	++	EGFR/HER1,HER4,MEK1
Tyrphostin AG 879	3	+	Trk
Tuxobertinib (BDTX-189)	2	++++	EGFR,RIPK2,BLK
Epertinib hydrochloride	0	++++	EGFR,HER4
TAS0728	1	+++
Tyrphostin AG-528	0	+	EGFR
SU5204	1	+	VEGFR-2
Pyrotinib dimaleate	4	+	EGFR
Poziotinib	35	++++	HER1,HER4
HER2-Inhibitor-1	1	✔
Zongertinib	0	✔	EGFR-Ex20ins
Nordihydroguaiaretic acid (NDGA)	1	✔	p300,IGF-1R,lipoxygenase
EGCG ((-)-Epigallocatechin Gallate)	42	✔	FASN,EGFR,DNMT

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Disitamab Vedotin (RC-48 ,RC 480-ADC) is an antibody-drug conjugate(ADC) composed of anti-[ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)] humanized monoclonal antibody, conjugated to monomethylauristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker. Disitamab Vedotin has the potential for use in solid tumors mainly in advanced breast cancer.
References	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090390/

Description

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090390/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	2136633-23-1
DAR	3.8
ADC antiody	Disitamab
ADC cytotoxin	MMAE
Formulation	1xPBS
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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