Pembrolizumab (anti-PD-1)
Catalog No.A2005 Synonyms: MK-3475, lambrolizumab Humanized and Non-humanized mouse model applicable
For research use only. Not for use in humans.
Pembrolizumab (anti-PD-1) is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.
Quality Control
Choose Selective PD-1/PD-L1 Inhibitors
Biological Activity
| Description | Pembrolizumab (anti-PD-1) is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD. | |
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| In vivo | In addition to Melanoma and Lung carcinoma, pembrolizumab has also demonstrated efficacy in other advanced solid tumors and hematologic malignancies. Pembrolizumab had an acceptable side-effect profile and showed antitumor activity in patients with advanced non-small-cell lung cancer[2]. |
Protocol
| Cell Research: |
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| Animal Research: |
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Product Details
| CAS No. | 1374853-91-4 |
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| Formulation | PBS buffer, pH 7.2 |
| Isotype | Human IgG4 |
| Source | CHO cells |
| Storage | Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles |
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Frequently Asked Questions
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Question 1:
How to store the antibody?
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Answer:
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.
