Pembrolizumab (anti-PD-1)

Synonyms: MK-3475, lambrolizumab

Pembrolizumab (anti-PD-1) is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.

Pembrolizumab (anti-PD-1) Chemical Structure

Click to purchase the isotype control of Pembrolizumab (anti-PD-1)

Selleck's Pembrolizumab (anti-PD-1) has been cited by 46 publications

Purity & Quality Control

Batch: Purity: 99% Protein concentration: 15.94mg/ml Endotoxin Level: <1EU/mg
99

Choose Selective PD-1/PD-L1 Inhibitors

Biological Activity

Description Pembrolizumab (anti-PD-1) is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.
Features Human IgG4
Targets
PD-1 [1]
(Cell-free assay)
In Vitro
In vitro

The level of LDH and apoptosis are significantly higher in those treated with dexamethasone plus PD1 inhibitor pembrolizumab than other groups.[1]

Cell Research:

Cancer cells were incubated with dexamethasone for 48 h followed by co-cultured with PBMCs with effector/target ratio of 10:1 and the addition of PD1 inhibitor (pembrolizumab; 5 μg/mL) for another 48 h. LDH level was detected.

In Vivo
In vivo

Pembrolizumab and dexamethasone synergistically suppress tumor growth of pancreatic cancer in vivo.[1]

Animal Research

Animal Models: Immune reconstituted NOD/SCID mice model
Dosages: 5 mg/kg
Administration: i.v.
Reference: [1]
 

Product Details

CAS No. 1374853-91-4
Isotype Human IgG4
Source CHO cells
Formulation PBS buffer, pH 7.2
Storage
(From the date of receipt)
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

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Frequently Asked Questions

Question 1:
How to store the antibody?

Answer:
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.

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