Vitamin B12

Catalog No.S1902 Synonyms: Cobalamin, Cyanocobalamin

For research use only.

Vitamin B12 (Cobalamin, Cyanocobalamin) is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.

Vitamin B12 Chemical Structure

CAS No. 68-19-9

Selleck's Vitamin B12 has been cited by 2 Publications

Purity & Quality Control

Choose Selective Vitamin Inhibitors

Biological Activity

Description Vitamin B12 (Cobalamin, Cyanocobalamin) is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 75 mg/mL
(55.33 mM)
Ethanol 10 mg/mL
(7.37 mM)
Water 6 mg/mL
(4.42 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1355.37


CAS No. 68-19-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05005897 Not yet recruiting Biological: Cyanocobalamin Vitamin B 12 Deficiency Sykehuset Innlandet HF|University of Bergen|University of Oslo|Inland Norway University of Applied Sciences October 15 2021 Phase 2|Phase 3
NCT03853304 Not yet recruiting Other: + Folic acid|Other: + Vitamin B12|Other: DFS Anemia|Folate Deficiency|Vitamin B 12 Deficiency Cornell University|Centers for Disease Control and Prevention|Arogyavaram Medical Centre October 2021 Not Applicable
NCT04310059 Not yet recruiting Dietary Supplement: Folic acid|Dietary Supplement: Materna Thalassemia|Folic Acid Deficiency Anemia The University of Hong Kong|Queen Mary Hospital Hong Kong July 1 2021 Not Applicable
NCT04641663 Recruiting Dietary Supplement: Multi-target Dietary Supplement (MTDS) Aging|Age-related Cognitive Decline Douglas Boreham|McMaster University|Northern Ontario School of Medicine July 15 2021 Not Applicable
NCT04866264 Not yet recruiting Device: eNutrition Optimizer Diabetes|Hypertension|Frailty|Dementia|Cardiovascular Diseases Heike Bischoff-Ferrari|University of Zurich June 2021 Not Applicable

(data from, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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