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(±)-α-Tocopherol Vitamin chemical

Name: (±)-α-Tocopherol
Brand: Selleck Chemicals
SKU: S6104
Availability: InStock
Rating: 5 (9 reviews)

Cat.No.S6104

(±)-α-Tocopherol is a biologically active form of vitamin E, which is a lipid-soluble antioxidant that protects cellular membranes from oxidative damage.

(±)-α-Tocopherol Vitamin chemical Chemical Structure

Quality Control

Batch: S610401 Ethanol]100 mg/mL]false]DMSO]16 mg/mL]true]Water]Insoluble]false Purity: 99.59%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

99.59

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Carbohydrate Metabolism Mitochondrial Metabolism Casein Kinase
Other Vitamin Inhibitors	Trolox Nicotinic Acid Sodium ascorbate D-Pantethine Amprolium HCl Thiamine pyrophosphate hydrochloride D-Pantothenate Sodium Calcium D-Panthotenate Tocofersolan Ergosterol

Solubility

In vitro
Batch:

Ethanol : 100 mg/mL

DMSO : 16 mg/mL (37.14 mM) Warmed with 60°C water bath; Ultrasonicated;
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.800mg/ml (1.86mM)	Taking the 1 mL working solution as an example, add 50 μL of 16 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.800mg/ml (1.86mM)	Taking the 1 mL working solution as an example, add 50 μL of 16 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	430.71	Formula	C₂₉H₅₀O₂	Storage (From the date of receipt)	2 years 4°C(in the dark) liquid
CAS No.	10191-41-0	--		Storage (From the date of receipt)	2 years 4°C(in the dark) liquid
Synonyms	(±)-Vitamin E acetate			SMILES	CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C

Read more about storage stability CAS number SMILES

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-06)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06634056	RECRUITING	Non-Small Cell Lung Cancer; Radiation Induced Lung Injury (RILI)	University Health Network, Toronto	2026-06-15	PHASE2
NCT06912763	RECRUITING	Fibrosis Syndrome; Lymphedema; Head &Amp; Neck Cancer; Fibrosis	M.D. Anderson Cancer Center	2025-08-08	PHASE2
NCT06494111	RECRUITING	Lymphedema; Fibrosis	M.D. Anderson Cancer Center	2025-02-13	PHASE2
NCT07796204	NOT_YET_RECRUITING	Obesity; Type 2 Diabetes	Pennington Biomedical Research Center	2026-09-03
NCT05795647	RECRUITING	Medication-related Osteonecrosis of the Jaw (MRONJ)	University Hospital, Limoges	2024-02-29	PHASE2
NCT07782411	NOT_YET_RECRUITING	Obesity (BMI>30); Neuroinflammation	Autonomous University of Morelos	2026-08-10

Tech Support

Handling Instructions

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