Vitamin K1

Catalog No.S4698 Synonyms: Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione

For research use only.

Vitamin K1 (Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione), made by plants, is a major type of dietary vitamin K, which is well-known for its role in blood clotting. Vitamin K1 is directly involved in photosynthesis.

Vitamin K1 Chemical Structure

CAS No. 84-80-0

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Biological Activity

Description Vitamin K1 (Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione), made by plants, is a major type of dietary vitamin K, which is well-known for its role in blood clotting. Vitamin K1 is directly involved in photosynthesis.

Protocol (from reference)

Chemical Information

Molecular Weight 450.70
Formula

C31H46O2

Density 0.984 g/mL at 25 °C
CAS No. 84-80-0
Storage 2 years -20°C liquid
Smiles CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05060809 Completed Drug: oral vitamin k1 (phylloquinone) Vascular Calcification Assiut University January 1 2018 Phase 4
NCT01763307 Unknown status Drug: RECONVAL CREAM|Drug: PLACEBO Rash Due to Epidermal Growth Factor Receptor Inhibitors Hadassah Medical Organization January 2013 Phase 2
NCT02515214 Recruiting -- Bariatric Surgery Candidate|Pregnancy Universitaire Ziekenhuizen Leuven July 2012 --
NCT02505282 Completed Other: Vitamin K status Orthostatic Hypotension University of Dundee|British Geriatrics Society April 2012 --
NCT01474460 Completed Dietary Supplement: phytonadione Coagulation Delay James A. Haley Veterans Administration Hospital September 2011 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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