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Vitamin K1 Vitamin chemical

Name: Vitamin K1
Brand: Selleck Chemicals
SKU: S4698
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4698

Vitamin K1 (Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione), made by plants, is a major type of dietary vitamin K, which is well-known for its role in blood clotting. This compound is directly involved in photosynthesis.

Chemical Structure

Molecular Weight: 450.70

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Quality Control

Batch: Purity: 99.46%

99.46

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Carbohydrate Metabolism Mitochondrial Metabolism Casein Kinase
Other Vitamin Inhibitors	Trolox Nicotinic Acid Sodium ascorbate D-Pantethine Amprolium HCl Thiamine pyrophosphate hydrochloride D-Pantothenate Sodium Calcium D-Panthotenate Tocofersolan Ergosterol

Solubility

In vitro
Batch:

DMSO : 90 mg/mL (199.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 90 mg/mL

Ethanol : 90 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%absolute ethyl alcohol 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.840mg/ml (1.86mM)	Taking the 1 mL working solution as an example, add 50 μL of 16.7 mg/ml clarified absolute ethyl alcohol stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL Adjust the volume of ddH2O to 1 mL. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	450.70	Formula	C₃₁H₄₆O₂	Storage (From the date of receipt)	2 years -20°C liquid
CAS No.	84-80-0	--		Storage (From the date of receipt)	2 years -20°C liquid
Synonyms	Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione			SMILES	CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-08-13)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05018221	RECRUITING	Calciphylaxis	University of Sydney	2021-08-26	PHASE3
NCT06385275	ACTIVE_NOT_RECRUITING	Osteo Arthritis Knee	Boston University	2025-06-03	PHASE1; PHASE2
NCT04752813	ACTIVE_NOT_RECRUITING	Glioblastoma; Glioblastoma Multiforme	BPGbio	2022-08-22	PHASE2
NCT06839352	COMPLETED	Variceal Bleeding	Zagazig University	2022-10-03	PHASE4
NCT05505552	Recruiting	Osteo Arthritis Knee	Tufts University\|University of North Carolina Chapel Hill\|Tufts Medical Center	2023-09-20	Not Applicable
NCT05610137	Completed	Dietary Intake	Vanessa Corrales Agudelo\|Vidarium Nutrition Health and Wellness Research Center	2022-10-18	--

Tech Support

Handling Instructions

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