Home Metabolism Vitamin chemical Retinyl (Vitamin A) Palmitate

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Retinyl (Vitamin A) Palmitate Vitamin chemical

Cat.No.S4126

Retinyl (Vitamin A) Palmitate is a more stable, synthetic version of the essential nutrient vitamin A joined to palmitic acid.
Retinyl (Vitamin A) Palmitate Vitamin chemical Chemical Structure

Chemical Structure

Molecular Weight: 524.86

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Quality Control

Batch: S412601 Ethanol]5 mg/mL]false]DMSO]3 mg/mL]false]Water]Insoluble]false Purity: 99.11%
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99.11

Solubility

In vitro
Batch:

Ethanol : 5 mg/mL

DMSO : 3 mg/mL (5.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

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In vivo
Batch:

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 524.86 Formula

C36H60O2

 Storage (From the date of receipt) 2 years  -20°C  liquid
CAS No. 79-81-2 Download SDF Storage of Stock Solutions

Synonyms Vitamin A palmitate Smiles CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(CCCC1(C)C)C

Mechanism of Action

In vitro
The microencapsulation of vitamin A palmitate by gelatin-acacia complex is a promising method for converting an oily vitamin to solid powders for an aid to handling and ease of incorporation in preparations.
In vivo
Vitamin A Palmitate (80 mg/kg daily p.o.) or (800 mg/kg once a week p.o.) dose-dependently decreases the size of papillomas in mice, the daily administration induces a somewhat higher extent of regression than the weekly application if the total doses are compared. Water miscible solutions of Vitamin A Palmitate as well as of Vitamin A acid given by the oral route elicit the same effect on papillomas. Vitamin A Palmitate (A single simultaneous injection of 150 g) enhances cell-mediated immunity to sheep red blood cells(SRBC) as early as 3 days following immunization, and the enhancement persists for at least 3 weeks.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01958775 Completed
Dyslipidemia
University Health Network Toronto
 March 2012 Phase 3
NCT02867488 Completed
Biological Availability
Iowa State University
 April 2009 Not Applicable

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