research use only

Vitamin A Acetate Vitamin chemical

Name: Vitamin A Acetate
Brand: Selleck Chemicals
SKU: S4083
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S4083

Vitamin A Acetate (Retinyl, Retinol) is a group of unsaturated nutritional hydrocarbons, that includes retinol, retinal, retinoic acid, and several provitamin A carotenoids, among which beta-carotene is the most important.

Chemical Structure

Molecular Weight: 328.49

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: Purity: 99.62%

99.62

Related Targets	P450 (e.g. CYP17) Dehydrogenase PDE phosphatase PPAR HSP Transferase Carbohydrate Metabolism Mitochondrial Metabolism Drug Metabolite Casein Kinase Serine/threonin kinase Lipoxygenase LPL Receptor Phospholipase (e.g. PLA) Retinoid Receptor DPP ACE Peroxidases Amino Acids and Derivatives Fatty Acid Synthase Glucokinase FXR HMG-CoA Reductase Carbonic Anhydrase Lipase Decarboxylase DHFR IDO/TDO Hydroxylase
Related Products	Trolox Nicotinic Acid Sodium ascorbate Amprolium HCl Thiamine pyrophosphate hydrochloride Ergosterol Fursultiamine D-Pantothenate Sodium RBP4 Antibody [H11M4] Thiamine monochloride Calcium D-Panthotenate Tocofersolan Chlorindione 7-Dehydrocholesterol NQO1 Antibody [E6P4] Sulbutiamine Thiamine nitrate Pyridoxal 5-phosphate monohydrate D panthenol Beta Carotene Menadiol Diacetate Amprolium Methylcobalamin Apocarotenal Inositol niacinate D-Pantethine Pyridoxal phosphate

Chemical Information, Storage & Stability

Molecular Weight	328.49	Formula	C₂₂H₃₂O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	127-47-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Retinyl (Retinol) Acetate			Smiles	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCOC(=O)C)C)C

Solubility

In vitro
Batch:

DMSO : 65 mg/mL (197.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 65 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Vitamin A deficiency impairs innate immunity by impeding normal regeneration of mucosal barriers damaged by infection, and by diminishing the function of neutrophils, macrophages, and natural killer cells. Vitamin A is also required for adaptive immunity and plays a role in the development of T both-helper (Th) cells and B-cells. Vitamin A deficiency diminishes antibody-mediated responses directed by Th2 cells, although some aspects of Th1-mediated immunity are also diminished. ^[1]
In vivo	Vitamin A acetate (VAA) (fed on an otherwise conventional diet) responds to 10⁵ semiallogeneic cells (a suboptimal dose) in a host-versus-graft (HvG) reaction in mice, whereas mice on a conventional diet do not. ^[2] Vitamin A acetate can bring a solid and long-lasting state of tolerance induced by the intravenous injection into newborn CBA mice of lymphoid cells from (CBA X C57BL/10ScSn) F1 hybrids to an end, the effect of which is to increase the proportion of the moiety of the T-cell population that produces IL-2. ^[3] Vitamin A acetate-supplemented diet develops a positive skin reaction to purified protein derivative of mycobacteria in High-dose Mycobacterium bovis-infected mice, and their spleen cells show an increased IL-2 production in vitro. ^[4]
References	[1] https://pubmed.ncbi.nlm.nih.gov/11375434/ [2] https://pubmed.ncbi.nlm.nih.gov/6601243/ [3] https://pubmed.ncbi.nlm.nih.gov/3881767/ [4] https://pubmed.ncbi.nlm.nih.gov/3886551/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06319079	Not yet recruiting	Lactating Mothers\|Infants	Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri	March 2024	Not Applicable
NCT06058442	Recruiting	Gastrectomy	University of Leipzig	January 24 2024	Phase 3
NCT06057597	Recruiting	Obesity\|Morbid	Assistance Publique - Hôpitaux de Paris	November 13 2023	Not Applicable
NCT06081114	Recruiting	Micronutrient Status	Johns Hopkins Bloomberg School of Public Health\|International Center for Diarrheal Disease Research Bangladesh (icddrb)\|Bill and Melinda Gates Foundation	October 22 2023	Not Applicable
NCT06155448	Active not recruiting	Malaria	Malaria Consortium\|Nigerian Institute of Medical Research\|London School of Hygiene and Tropical Medicine\|Northwestern University	August 8 2023	Not Applicable

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):