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Paricalcitol Vitamin agonist

Name: Paricalcitol
Brand: Selleck Chemicals
SKU: S6681
Availability: InStock
Rating: 5 (5 reviews)

Cat.No.S6681

Paricalcitol is a selective vitamin D receptor agonist. This compound suppresses parathyroid hormone mRNA expression and inhibits parathyroid cell proliferation. It is used to treat secondary hyperparathyroidism in chronic kidney disease.

Chemical Structure

Molecular Weight: 416.64

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S668101 DMSO]83 mg/mL]false]Ethanol]13 mg/mL]false]Water]Insoluble]false Purity: 99.99%

99.99

Related Targets	P450 (e.g. CYP17) Dehydrogenase PDE phosphatase PPAR HSP (HSP90) Transferase Carbohydrate Metabolism Mitochondrial Metabolism Casein Kinase Serine/threonin kinase Lipoxygenase Phospholipase (e.g. PLA) Retinoid Receptor DPP ACE Peroxidases Fatty Acid Synthase FXR HMG-CoA Reductase Carbonic Anhydrase Lipase Decarboxylase DHFR IDO/TDO Hydroxylase PCSK9 OXPHOS ROR Acyltransferase
Related Products	Trolox Nicotinic Acid Sodium ascorbate Amprolium HCl Thiamine pyrophosphate hydrochloride Ergosterol Fursultiamine D-Pantothenate Sodium

Chemical Information, Storage & Stability

Molecular Weight	416.64	Formula	C₂₇H₄₄O₃	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	131918-61-1	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Paracalcin,19-Nor-1-25-OH2D2,19-Nor-colecalciferol			Smiles	CC(C=CC(C)C(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3)O)O)C

Solubility

In vitro
Batch:

DMSO : 83 mg/mL ( (199.21 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 13 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.070mg/ml (4.97mM)	Taking the 1 mL working solution as an example, add 50 μL of 41.4 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.380mg/ml (3.31mM)	Taking the 1 mL working solution as an example, add 50 μL of 27.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	vitamin D receptor ^[1]
References	https://pubmed.ncbi.nlm.nih.gov/20204178/ https://pubmed.ncbi.nlm.nih.gov/18360604/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05664880	Recruiting	Chronic Pancreatitis	Cedars-Sinai Medical Center\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	June 1 2023	Early Phase 1
NCT03415854	Completed	Pancreatic Cancer\|Pancreatic Ductal Adenocarcinoma\|Pancreatic Adenocarcinoma\|Pancreas Metastases\|Adenocarcinoma	HonorHealth Research Institute\|Barts Cancer Institute\|Abramson Cancer Center at Penn Medicine\|Salk Institute for Biological Studies\|Mayo Clinic\|Princeton University\|Imaging Endpoints\|Translational Genomics Research Institute\|Stand Up To Cancer\|Cancer Research UK\|Lustgarten Foundation\|University of California San Diego	January 31 2018	Phase 2
NCT03331562	Completed	Pancreatic Cancer\|Pancreas Adenocarcinoma\|Advanced Pancreatic Cancer\|Metastatic Pancreatic Cancer\|Metastatic Pancreatic Adenocarcinoma	Translational Genomics Research Institute\|Stand Up To Cancer\|Merck Sharp & Dohme LLC	December 27 2017	Phase 2
NCT02686827	Completed	Hypersensitivity	Laurian Jongejan\|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	October 2015	Phase 2
NCT01725113	Terminated	Kidney Failure\|Secondary Hyperparathyroidism\|Hyperphosphatemia\|Hypercalcemia	Winthrop University Hospital	November 2012	Phase 4

Tech Support

Handling Instructions

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