For research use only.
Catalog No.S4605 Synonyms: Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate
CAS No. 59-30-3
Folic acid (Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate), a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
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|Description||Folic acid (Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate), a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.|
Folic acid treatment induces dose-related increases in BRCA1 mRNA expression in HepG2, Huh-7D12, Hs578T, and JURKAT and in BRCA2 in HepG2, Hs578T, MCF7, and MDA-MB-157 cells. FA does not affect the corresponding normal cells or on any of the ovarian cell lines. Folic acid induces increased BRCA1 protein expression in Hs578T, but not HepG2 cells, whereas BRCA2 protein levels are undetectable. FA treatment does not alter DNA repair in liver-derived cells, whereas there are transient effects on breast-derived cells. There is no effect of FA treatment on BRCA1 or BRCA2 DNA methylation, although there is some variation in the methylation of specific CpG loci between some cell lines.
|In vitro||DMSO||2 mg/mL warmed (4.53 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04310059||Not yet recruiting||Dietary Supplement: Folic acid|Dietary Supplement: Materna||Thalassemia|Folic Acid Deficiency Anemia||The University of Hong Kong|Queen Mary Hospital Hong Kong||January 1 2021||Not Applicable|
|NCT03853304||Not yet recruiting||Other: + Folic acid|Other: + Vitamin B12|Other: DFS||Anemia|Folate Deficiency|Vitamin B 12 Deficiency||Cornell University|Centers for Disease Control and Prevention|Arogyavaram Medical Centre||January 2021||Not Applicable|
|NCT04641663||Not yet recruiting||Dietary Supplement: Multi-target Dietary Supplement (MTDS)||Aging|Age-related Cognitive Decline||Douglas Boreham|McMaster University|Northern Ontario School of Medicine||January 4 2021||Not Applicable|
|NCT04583150||Recruiting||Procedure: Bariatric surgery||Bariatric Surgery|Obesity|Reproductive Health|Fertility||Assistance Publique - Hôpitaux de Paris||December 3 2020||--|
|NCT04589793||Not yet recruiting||Behavioral: Life Style||Life Style|Fertility Disorders||Helsinki University Central Hospital|University of Helsinki|University of Eastern Finland||November 2020||Not Applicable|
|NCT04632771||Recruiting||Other: N/A (observational study)||Iron Deficiency|Vitamin A Deficiency|Vitamin B 12 Deficiency|Folate Deficiency|Zinc Deficiency|Dietary Habits|Anemia||University of California Davis|University of Ghana|Newcastle University|Penn State University|Helen Keller International||October 19 2020||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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