Folic acid

Synonyms: Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate

Folic acid (Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate), a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.

Folic acid Chemical Structure

Folic acid Chemical Structure

CAS: 59-30-3

Selleck's Folic acid has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.93%
99.93

Folic acid Related Products

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Biological Activity

Description Folic acid (Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate), a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
In vitro
In vitro Folic acid treatment induces dose-related increases in BRCA1 mRNA expression in HepG2, Huh-7D12, Hs578T, and JURKAT and in BRCA2 in HepG2, Hs578T, MCF7, and MDA-MB-157 cells. FA does not affect the corresponding normal cells or on any of the ovarian cell lines. Folic acid induces increased BRCA1 protein expression in Hs578T, but not HepG2 cells, whereas BRCA2 protein levels are undetectable. FA treatment does not alter DNA repair in liver-derived cells, whereas there are transient effects on breast-derived cells. There is no effect of FA treatment on BRCA1 or BRCA2 DNA methylation, although there is some variation in the methylation of specific CpG loci between some cell lines[1].
Cell Research Cell lines HepG2, Huh-7D12, Hs578T, JURKAT, Hs578T, MCF7, and MDA-MB-157 cells
Concentrations 0, 25, 50, 75, or 100 nmol/L
Incubation Time 72 h
Method

To determine the effect of FA supplementation on BRCA1 and BRCA2 mRNA expression, all cell lines were treated with 0, 25, 50, 75, or 100 nmol/L FA for 72 hours before harvesting in TRI Reagent according to the manufacturer’s instructions.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04310059 Not yet recruiting
Thalassemia|Folic Acid Deficiency Anemia
The University of Hong Kong|Queen Mary Hospital Hong Kong
July 1 2024 Not Applicable
NCT06057597 Recruiting
Obesity|Morbid
Assistance Publique - Hôpitaux de Paris
November 13 2023 Not Applicable
NCT05500690 Recruiting
Pregnancy; Spina Bifida Fetal|Environmental Exposure
Boston Children''s Hospital|National Institute of Neurosciences and Hospital Dhaka
October 8 2023 Not Applicable
NCT03853304 Active not recruiting
Anemia|Folate Deficiency|Vitamin B 12 Deficiency
Cornell University|Centers for Disease Control and Prevention|Arogyavaram Medical Centre
October 1 2023 Not Applicable

Chemical Information & Solubility

Molecular Weight 441.40 Formula

C19H19N7O6

CAS No. 59-30-3 SDF Download Folic acid SDF
Smiles C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 2 mg/mL ( (4.53 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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