NCT-501

NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.

NCT-501 Chemical Structure

NCT-501 Chemical Structure

CAS: 1802088-50-1

Selleck's NCT-501 has been cited by 1 publication

Purity & Quality Control

Batch: S794101 DMSO] 32 mg/mL] false] Ethanol] 25 mg/mL] false] Water] Insoluble] false Purity: 99.99%
99.99

NCT-501 Related Products

Choose Selective Dehydrogenase Inhibitors

Biological Activity

Description NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.
Targets
ALDH1A1 [1]
40 nM
In vitro
In vitro In Caco-2 cell line, NCT-501 exhibits excellent permeability. [1]
In Vivo
In vivo In CD1 Mice, NCT-501 is well absorbed and distributed but rapidly metabolized and/or excreted. [1]

Chemical Information & Solubility

Molecular Weight 416.52 Formula

C21H32N6O3

CAS No. 1802088-50-1 SDF Download NCT-501 SDF
Smiles CC(C)CCN1C(=NC2=C1C(=O)N(C(=O)N2C)C)CN3CCN(CC3)C(=O)C4CC4
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (76.82 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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