For research use only.

Catalog No.S7241

3 publications

AGI-6780 Chemical Structure

CAS No. 1432660-47-3

AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.

Selleck's AGI-6780 has been cited by 3 publications

2 Customer Reviews

  • Western blot of KMM-1 and NCI-H929 cells, UT, treated with DMSO, AGI-6780 (KMM-1: 5 μM; NCI-H929: 10 μM), CFZ (KMM-1: 5 nM; NCI-H929: 2.5 nM), or a combination of the 2 drugs. Cell lysates were immunoblotted using the indicated antibodies 24 hours posttreatment. Vinculin protein expression was included for protein loading normalization.

    Blood, 2018, doi: 10.1182/blood-2018-05-850826. AGI-6780 purchased from Selleck.

    (A) The growth inhibition rates of different human lung cancer cells and normal MRC5 lung fibroblasts in the presence of AGI-6780. (B) IDH activity was analyzed in H460 and A549 lung cancer cells treated with DMSO or AGI-6780 (20 μM) for 24 h (** p < 0.01).

    Theranostics, 2018, 8(15):4050-4061. AGI-6780 purchased from Selleck.

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Biological Activity

Description AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.
IDH2 R140Q mutant [1]
23 nM
In vitro

AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples. [1]


Solubility (25°C)

In vitro DMSO 96 mg/mL (199.37 mM)
Ethanol 96 mg/mL (199.37 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 481.51

C21 H18 F3 N3 O3 S2

CAS No. 1432660-47-3
Storage powder
in solvent
Synonyms N/A
Smiles C1CC1NS(=O)(=O)C2=CC(=C(C=C2)C3=CSC=C3)NC(=O)NC4=CC=CC(=C4)C(F)(F)F

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Dehydrogenase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID