Glycyrrhizin (NSC 167409)

Catalog No.S2302

For research use only.

Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).

Glycyrrhizin (NSC 167409) Chemical Structure

CAS No. 1405-86-3

Selleck's Glycyrrhizin (NSC 167409) has been cited by 27 publications

Purity & Quality Control

Choose Selective Dehydrogenase Inhibitors

Other Dehydrogenase Products

Biological Activity

Description Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).
Targets
11 beta-hydroxysteroid dehydrogenase [1] HMGB1 [2] MAO [4]
(Cell-free)
0.16 μM
In vitro

Glycyrrhizin inhibits monoamine oxidase (MAO) with the IC50 value of 0.16 μM[4].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 NWn5W41HTnWwY4Tpc44h[XO|YYm= MXHJcohq[mm2aX;uJI9nKGi3bXHuJI1q[3Kxc3;tZYwhOTGkZYThMWhUTDJiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDjc453\XK|aX;uJI9nKFt|SG3jc5J1cXOxbnWgeI8hYzOKXXPvdpRqe2:uIHL5JJNkcW62aXzsZZRqd25icILvfIlucXS7IHHzd4F6NCCLQ{WwQVAvODBzzszNMi=> Ml7GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3NkSxNFgoRjF7NU[0NVA5RC:jPh?=
HEK293 MlHsSpVv[3Srb36gZZN{[Xl? NYnOc3liUW6qaXLpeIlwdiCxZjDtc5V{\SCvaXPyc5NwdWGuIEGxZoV1[S2KU1SxJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMh[2:wdnXyd4lwdiCxZjDbN2he[2:{dHnzc45mKHSxIGuzTH1kd3K2aYPvcEBjgSC|Y3nueIltdGG2aX;uJJBzd3irbXn0fUBie3OjeTygTWM2OD1yLkCwPO69VS5? NHXrTpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW2OFExQCd-MUm1OlQyODh:L3G+
HEK293 MXrGeY5kfGmxbjDhd5NigQ>? NEfqN3FKdmirYnn0bY9vKG:oIHj1cYFvKG2rY4Lvd49u[WxiMUHi[ZRiNUiVREGg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bkd264ZYLzbY9vKG:oIGuzTH1kd3K2aYPvcoUhfG9iW{PIYYNwenSrc3;sJIJ6KHOlaX70bYxt[XSrb36gdJJwgGmvaYT5JIF{e2G7LDDJR|UxRTBwMEJOwG0v M3zKWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NU[0NVA5Lz5zOUW2OFExQDxxYU6=
HEK293 NUH3[Wk2TnWwY4Tpc44h[XO|YYm= NVTYRm52UW6qaXLpeIlwdiCxZjDtc5V{\SCuaY\ldkBucWO{b4PvcYUhOTGkZYThTHNFOSCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHPvcpZmenOrb36gc4YhYzOKXXPvdpRqe2:wZTDpcpRwKFt|SG3jc5J1cXOxbDDifUB{[2mwdHnscIF1cW:wIIDyc5hqdWm2eTDhd5NigSxiSVO1NF0xNjBzNd88UU4> NX25dHVVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1O|QxPTZpPkG5OVc1ODV4PD;hQi=>
HEK293 NFTVNYhHfW6ldHnvckBie3OjeR?= M2P4bWlvcGmkaYTpc44hd2ZiaIXtZY4hOTGkZYThMWhUTDJiZYjwdoV{e2WmIHnuJIh2dWGwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyClb372[ZJ{cW:wIH;mJHs{UF2lb4L0bZNwdmVidH:gX|NJZWOxcoTpd49tKGK7IIPjbY51cWyuYYTpc44heHKxeHntbZR6KGG|c3H5MEBKSzVyPUCuNFAxP87:TT6= MlzQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNEiyOFEoRjJ{MUS4NlQyRC:jPh?=
HEK293 MmDESpVv[3Srb36gZZN{[Xl? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJFEy[mW2YT3IV2QyKGW6cILld5Nm\CCrbjDoeY1idiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMh[2:wdnXyd4lwdiCxZjDbN2he[2:{dHnzc45mKHSxIGuzTH1kd3K2aYPvcEBjgSC|Y3nueIltdGG2aX;uJJBzd3irbXn0fUBie3OjeTygTWM2OD1yLkCxPFbPxE1w MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF2OEK0NUc,OjJzNEiyOFE9N2F-
HEK293 MWfGeY5kfGmxbjDhd5NigQ>? Mn\QTY5pcWKrdHnvckBw\iCvb4Xz[UAyOWKndHGtTHNFOSCneIDy[ZN{\WRiaX6gbJVu[W5iSFXLNlk{KGOnbHzzJIF{e2W|c3XkJIF{KGOxbo\ldpNqd25ib3[gX|NJZWOxcoTpd49v\SC2bzDbN2he[2:{dHnzc4wh[nlic3PpcpRqdGyjdHnvckBxem:6aX3peJkh[XO|YYmsJGlEPTB;MD6wNlk2|ryPLh?= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF2OEK0NUc,OjJzNEiyOFE9N2F-
HEK293 M3v5TGZ2dmO2aX;uJIF{e2G7 NU\pTnFUUW6qaXLpeIlwdiCxZjDoeY1idiBzMXLleIEuUFOGMjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJINwdn[ncoPpc44hd2ZiW{PIYYNwenSrc3;u[UBqdnSxIGuzTH1kd3K2aYPvcEBjgSC|Y3nueIltdGG2aX;uJJBzd3irbXn0fUBie3OjeTygTWM2OD1yLkCwNFTPxE1w M4P4d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{[wOlM6Lz5{MkO2NFY{QTxxYU6=
HEK293 NEHMc45HfW6ldHnvckBie3OjeR?= MXvJcohq[mm2aX;uJI9nKG2xdYPlJFEy[mW2YT3IV2QyKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNiY3;ueoVze2mxbjDv[kBcO0ifY3;yeIl{d26nIHnueI8hYzOKXXPvdpRqe2:uIHL5JJNkcW62aXzsZZRqd25icILvfIlucXS7IHHzd4F6NCCLQ{WwQVAvODB|zszNMi=> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN4ME[zPUc,OjJ|NkC2N|k9N2F-
HEK293 NVvBVGRuTnWwY4Tpc44h[XO|YYm= M3rW[mlvcGmkaYTpc44hd2ZiaIXtZY4hOTGkZYThMWhUTDFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDjc453\XK|aX;uJI9nKFt|SG3jc5J1cXOxbnWgbY51dyCdM1jdZ49zfGm|b3ygZpkhe2OrboTpcIxifGmxbjDwdo95cW2rdImgZZN{[XluIFnDOVA:OC5yMEdOwG0v M3q0PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{[wOlM6Lz5{MkO2NFY{QTxxYU6=
HEK293 MoLLSpVv[3Srb36gZZN{[Xl? MmT4OlAhdWmwcx?= MljoTY5pcWKrdHnvckBw\iCqdX3hckAyOWKndHGtTHNFOiCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IGuzTH1kd3K2aYPvcEBxem:mdXP0bY9vKGGodHXyJFYxKG2rboOgZpkhW1CDLDDFR|UxRTBwMECx{txONg>? M2PkUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NESwOlI2Lz5{MkS0NFYzPTxxYU6=
HEK293 Mn:zSpVv[3Srb36gZZN{[Xl? MXy2NEBucW6| NGq2cZZKdmirYnn0bY9vKG:oIH3veZNmKDFzYnX0ZU1JW0RzIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgX|NJZWOxcoTpd49tKHC{b3T1Z5Rqd25iYX\0[ZIhPjBibXnud{BjgSCVUFGsJGVEPTB;MD6wNFjPxE1w MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR2ME[yOUc,OjJ2NEC2NlU9N2F-
HEK293 NWPNPFRpTnWwY4Tpc44h[XO|YYm= NHO4VHo3OCCvaX7z NFXhS2FKdmirYnn0bY9vKG:oIHj1cYFvKDFzYnX0ZU1JW0RzIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgX|NJZWOxcoTpd49tKHC{b3T1Z5Rqd25iYX\0[ZIhPjBibXnud{BjgSCVUFGsJGVEPTB;MD6wNe69VS5? NVG2TG5uRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OFA3OjVpPkKyOFQxPjJ3PD;hQi=>
MDCK M4nPZmN6fG:2b4jpZ4l1gSCjc4PhfS=> MXO0PEBpenN? MnzXR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygSWM2OD1zNT6y{txONg>? M4ToPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OECxPVM{Lz5{NUiwNVk{OzxxYU6=
MDCK NHLCVppCdnSrdnnyZYwh[XO|YYm= NGjKXYxCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBqdm[udXXufoEhSSC4aYL1d{ApSS:FYXzp[o9zdmmjL{C3M|A6MEhzTkGpLUBx\G1yOTDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJZqenW|IITpeIVzKGK7IHjlcYFo\2y3dHnuZZRqd25iYYPzZZkhcW5icILld4Vv[2Vib3[gNUUhe3W|cHXud4lwdiCxZjDjbIlkc2WwIHXyfZRpem:leYTld{whS0R3ME20O{42|ryPLh?= NX7IVIdrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NFE6OzNpPkK1PFAyQTN|PD;hQi=>
MDCK MmfZRY51cX[rcnHsJIF{e2G7 NV\aNJN{OTVibXnudy=> MV7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDJcoZtfWWwenGgRUB3cXK3czDBM3dUVi9|MzjINW4yMSCrbn\lZ5Rm\CCrbjDkc4chVUSFSzDj[YxteyCycnXpcoN2[mG2ZXSge4l1cCC4aYL1d{Bnd3JiMUWgcYlveyCob3zsc5dm\CCkeTDj[YxteyCjZHTpeIlwdiCvZXHzeZJm\CCjdDCzOkBpenNicH;zeEBqdm[nY4Tpc44tKEmFNUC9N|kvPs7:TT6= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh2MUG2PEc,OjZ6NEGxOlg9N2F-
Raji MVHBcpRqfmm{YXygZZN{[Xl? NV7kWpZVSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhTUKYIHnu[oVkfGWmIHnuJIh2dWGwIGLhbokh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdoFtKGenbn;t[UBkd3C7IH71cYJmenNiYomgdXJVNVCFUjDhcoFtgXOrczygSWM2OD1|MN88UU4> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd|MUSwNUc,OzB5M{G0NFE9N2F-
Vero E6 MnXsRY51cX[rcnHsJIF{e2G7 NIHHUoU6PiCqcoO= M4LsWGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGRGVlZ{IEG2OlgyKGmwZnXjeIVlKGmwIFHmdolk[W5iZ4Ll[Y4hdW:wa3X5JHZmem9iRU[gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdH;yfUBz[XSnIH;mJG5UPEJicH;zbZRqfmViY3XscJMhdWWjc4Xy[YQh[W[2ZYKgPVYhcHK|IHnuZ5Vj[XSrb36gZpkhTEGSSTDzeIFqdmmwZzDiZZNm\CCrbX31co9ndHWxcnXzZ4Vv[2VibXX0bI9lNCCLQ{WwQVgvOc7:TT6= NWnTTZJ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1NVk{PzVpPkOxOVE6Ozd3PD;hQi=>
Vero E6 MXHBcpRqfmm{YXygZZN{[Xl? M4jVOVExKHWP NHTxUVc6PiCqcoO= MWPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDESW5XOiBzNk[4NUBqdm[nY4Tl[EBqdiCDZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKEV4IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXK3czDpcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHH0JFExKHWPIH3lZZN2emWmIHHmeIVzKDl4IHjyd{BjgSC{ZY\ldpNmKHCqYYPlJINwdnS{YYP0JI1q[3Kxc3PvdJk> NYW2b4djRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1NVk{PzVpPkOxOVE6Ozd3PD;hQi=>
RAW264.7 M4iySGFvfGlvaX7mcIFudWG2b4L5JIF{e2G7 M{PyeVQxKHWP NFHie20zKGi{cx?= NVvyR3BtSW62aT3pcoZt[W2vYYTvdpkh[WO2aY\peJkhcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBPVyCycn;keYN1cW:wIHH0JFQxKHWPIIDy[Ylv[3WkYYTl[EBnd3JiMjDodpMh\m:ubH;3[YQh[nliTGDTJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEKwJIhzeyCkeTDHdolme3NiYYPzZZkhemWuYYTpeoUhfG9iY3;ueJJwdA>? NYDaTWpERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDRzNki3M{c,S2iHTVLMQE9iRg>?
RAW264.7 MkTqRY51cS2rbn\sZY1u[XSxcomgZZN{[Xl? MWGxNEB1dyB2MDD1US=> MYCyJIhzew>? MV7BcpRqNWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIFnMMVYheHKxZIXjeIlwdiCjdDCxNEB1dyB2MDD1UUBxemWrbnP1ZoF1\WRiZn;yJFIhcHK|IH\vcIxwf2WmIHL5JGxRWyCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkAzOCCqcoOgZpkhTUyLU1G= NYLlfmJWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDRzNki3M{c,S2iHTVLMQE9iRg>?
In vivo Glycyrrhizin increases the levels of monoamines like epinephrine and dopamine in brains of mice[3].

Protocol (from reference)

Animal Research:

[3]

  • Animal Models: Swiss albino mice
  • Dosages: 1.5, 3.0 and 6.0 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

10mg/mL

Chemical Information

Molecular Weight 822.93
Formula

C42H62O16

CAS No. 1405-86-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Glycyrrhizin (NSC 167409) | Glycyrrhizin (NSC 167409) supplier | purchase Glycyrrhizin (NSC 167409) | Glycyrrhizin (NSC 167409) cost | Glycyrrhizin (NSC 167409) manufacturer | order Glycyrrhizin (NSC 167409) | Glycyrrhizin (NSC 167409) distributor