D1 receptor Selective Inhibitors | Agonists | Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S4151 Penfluridol

Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.

Selective Dopamine receptor, Ki: 1.6 μM
S2452 Amfebutamone (Bupropion) HCl

Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4μM for the reuptake of dopamine and norepinephrine, respectively

S1726 Levodopa

Levodopa (Sinemet) is an amino acid precursor of dopamine with antiparkinsonian properties.

S2461 Domperidone

Domperidone is a dopamine blocker and an antidopaminergic reagent.

S2456 Chlorpromazine HCl

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents

S2529 Dopamine HCl

Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.

S1444 Ziprasidone HCl

Ziprasidone HCl was the fifth atypical antipsychotic.

S1724 Paliperidone

Paliperidone is an atypical antipsychotic.

S4257 Alizapride HCl

Alizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting.

S4274 Rotigotine

Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.

S2451 Amantadine HCl

Amantadine HCl is used to treat or prevent infections of the respiratory tract caused by a certain virus.

S1280 Amisulpride

Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.

S1763 Quetiapine Fumarate

Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.

S1771 Chlorprothixene

Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.

Pan D1 receptor, Ki: 18 nM
S4086 Loxapine Succinate

Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.

Pan D2 receptor (human), Ki: 24 nM; D2 receptor (Human), Ki: 24 nM; D1 receptor (human), Ki: 26 nM; D1 receptor (bovine), Ki: 62 nM
S2437 Rotundine

Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

Pan D1 receptor, IC50: 166 nM