- ALK1
- ALK2
- ALK3
- ALK4
- TGFβRI/ALK5
- ALK6
- TGFβRII
- TGF-β
ALK4 Inhibitors
Catalog No. | Product Name | Information | Selective / Pan | IC50 / Ki |
---|---|---|---|---|
S7530 | EW-7197 | EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. Phase 1. |
Pan | ALK4, IC50: 13 nM |
S2186 | SB505124 | SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6. |
Pan | ALK4, IC50: 129 nM |
S7359 | K02288 | K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA. |
Pan | ALK4, IC50: 302 nM; ALK4, IC50: 302 nM |
S7147 | LDN-212854 | LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively. |
Pan | ALK4, IC50: 2133 nM |
S1067 | SB431542 | SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases. |
Pan |