TGFβRII Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S6807 TA-02

TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. TA-02 especially inhibits TGFBR-2.

Selective
S2704 LY2109761

LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.

Pan TβRII, Ki: 300 nM
S2805 LY364947

LY364947 (HTS 466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.

Pan TGFβRII, IC50: 0.4 μM