TGF-β Selective Inhibitors | Activators | Modulators
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
Hesperetin is a bioflavonoid and, to be more specific, a flavanone.
Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Phase 3.
SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.
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