TGF-β Selective Inhibitors | Activators | Modulators

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2308 Hesperetin

Hesperetin is a bioflavonoid and, to be more specific, a flavanone.

S7658 Kartogenin

Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.

S2907 Pirfenidone

Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Phase 3.

S1067 SB431542

SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.