TGF-β Selective Inhibitors | Activators | Agonists | Modulators

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S6654 SRI-011381

SRI-011381 is a novel agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.

Selective
S0153 SJ000291942

SJ000291942 is a canonical bone morphogenetic proteins (BMP) signaling pathway activator.

Selective
S1576 Sulfasalazine (NSC 667219)

Sulfasalazine (NSC 667219, Azulfidine, Salazopyrin, Sulphasalazine) is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.

Selective
S6713 ITD-1

ITD-1 is a potent TGF-β inhibitor. It does not block the kinase activity of either type I (TGFBR1) or type II (TGFBR2) TGFβ receptors but potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A.

Selective
S5183 PD 169316

PD 169316 is a potent, selective and cell-permeable p38 MAP kinase inhibitor with IC50 of 89 nM. PD169316 abrogates signaling initiated by both TGFbeta and Activin A. PD169316 shows antiviral activity against Enterovirus71.

Selective
S2907 Pirfenidone (S-7701)

Pirfenidone (S-7701, AMR-69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Pirfenidone attenuates chemokine (CC motif) ligand-2 (CCL2) and CCL12 production with anti-fibrotic activity. Phase 3.

Selective
S2308 Hesperetin

Hesperetin is a bioflavonoid and, to be more specific, a flavanone.

Selective
S0752 AUDA

AUDA (compound 43) is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. AUDA downregulates Smad3 and p38 signaling pathways.

Pan