• ALK1
  • ALK2
  • ALK3
  • ALK4
  • TGFβRI/ALK5
  • ALK6
  • TGFβRII
  • TGF-β
  • Smad3
  • Smad4
  • Smad5
  • ALK7

ALK2 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7627 LDN-214117 LDN-214117 is a potent and selective BMP type I receptor kinase ALK2 inhibitor with IC50 of 24 nM. Selective ALK2, IC50: 24 nM
S7146 DMH1 DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. DMH1 inhibits autophagy. Selective ALK2, IC50: 107.9 nM
S2618 LDN-193189 LDN-193189 (DM3189) is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. For animal testing, the water-soluble