Salermide

Catalog No.S8460 Batch:S846001

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Technical Data

Formula

C26H22N2O2
Molecular Weight 394.47 CAS No. 1105698-15-4
Solubility (25°C)* In vitro DMSO 78 mg/mL (197.73 mM)
Ethanol 8 mg/mL (20.28 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.
Targets
SIRT1 [1] SIRT2 [1]
In vitro Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide is primarily because of a massive induction of apoptosis. Salermide induces apoptosis in cancer but not in normal cells. It induces strong apoptosis without any evident effect on the cell cycle in all the cancer cell lines analysed except in non-tumorigenic MRC5 cells. The induction of apoptosis is cell-type-specific and dose-dependent[1].
In vivo Salermide is well tolerated by mice at concentrations up to 100 μM. Its feeding does not produce any adverse health effects in mice as monitored by diet consumption, body-weight gain, and postural and behavioural changes[1].

Protocol (from reference)

Cell Assay:[1]
  • Cell lines

    MOLT4, MDA-MB-231 and SW480 cancer cell lines

  • Concentrations

    0, 25, 50, 75 or 100 μM

  • Incubation Time

    24 h

  • Method

    Cell viability is determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay as described earlier. IC50 index is calculated using four Salermide concentrations (25, 50, 75 and 100 μm) for 24 h. The percentage of apoptotic cells is determined with the FACSCalibur apparatus.
Animal Study:[1]
  • Animal Models

    Athymic (BALB/c, nu/nu) female nude mice

  • Dosages

    100 μl of 100 μM

  • Administration

    i.p.

Selleck's Salermide has been cited by 3 publications

SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival [ Cancer Lett, 2020, 501:20-30] PubMed: 33359449
Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice. [ Am J Transl Res, 2019, 11(8):4789-4799] PubMed: 31497199
The First Whole-Cell Proteome- and Lysine-Acetylome-Based Comparison between Trichophyton rubrum Conidial and Mycelial Stages. [ J Proteome Res, 2018, 17(4):1436-1451] PubMed: 29564889

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.