For research use only.

Catalog No.S7192

2 publications

PF-04620110 Chemical Structure

CAS No. 1109276-89-2

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

Selleck's PF-04620110 has been cited by 2 publications

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Biological Activity

Description PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
DGAT1 [1]
19 nM
In vivo In Rats, PF-04620110 reduces plasma triglyceride levels t doses of ≥0.1 mg/kg following a lipid challenge. [1] DGAT1 inhibition by PF-04620110 causes an enrichment of polyunsaturated fatty acids within the TG class of lipids in rodents. [2]


Animal Research:[1]
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  • Animal Models: Male Sprague Dawley rats
  • Dosages: ~10 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 49 mg/mL warmed (123.6 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 396.44


CAS No. 1109276-89-2
Storage powder
in solvent
Synonyms N/A
Smiles C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)N3CCOC4=NC=NC(=C4C3=O)N

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01298518 Completed Drug: PF-04620110|Drug: Placebo Type 2 Diabetes Patients Pfizer February 2011 Phase 1
NCT01166217 Completed Drug: PF-04620110 Healthy Pfizer|Bristol-Myers Squibb July 2010 Phase 1
NCT01146327 Completed Drug: PF-04620110|Drug: Placebo Healthy Pfizer|Bristol-Myers Squibb June 2010 Phase 1
NCT01064492 Completed Drug: PF-04620110 Healthy Volunteers Pfizer February 2010 Phase 1
NCT00959426 Completed Drug: PF-04620110|Drug: Placebo Obesity|Overweight|Healthy Pfizer|Bristol-Myers Squibb August 2009 Phase 1
NCT00799006 Completed Drug: Placebo|Drug: PF-04620110 Overweight Pfizer November 2008 Phase 1

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Transferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID