Catalog No.S3945 Synonyms: Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine
Molecular Weight(MW): 102.09
L-Cycloserine is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity.
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|Description||L-Cycloserine is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity.|
L-Cycloserine is a potent inhibitor of the first en zyme of the sphingolipid pathway, 3-ketodihydrosphin-gosine (3KDS) synthase (serine palmitoyltransferase) and causes an irreversible inhibition of 3KDS synthase derived from a bacterial source (Bacteroides levii) and from brain and heart microsomes in vitro.
|In vivo||Long-term administration of a low dosage of L-cycloserine subcutaneously to mice results in a significant reduction in the level of brain cerebrosides with little effect on other sphingolipids.|
|In vitro||Water||20 mg/mL (195.9 mM)|
|DMSO||8 mg/mL (78.36 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine|
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