L-Cycloserine

Catalog No.S3945 Synonyms: Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine

L-Cycloserine Chemical Structure

Molecular Weight(MW): 102.09

L-Cycloserine is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity.

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Biological Activity

Description L-Cycloserine is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity.
Targets
3-ketodihydrosphingosine synthetase [2]
()
In vitro

L-Cycloserine is a potent inhibitor of the first en zyme of the sphingolipid pathway, 3-ketodihydrosphin-gosine (3KDS) synthase (serine palmitoyltransferase) and causes an irreversible inhibition of 3KDS synthase derived from a bacterial source (Bacteroides levii) and from brain and heart microsomes in vitro[3].

In vivo Long-term administration of a low dosage of L-cycloserine subcutaneously to mice results in a significant reduction in the level of brain cerebrosides with little effect on other sphingolipids[3].

Protocol

Animal Research:[1]
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  • Animal Models: New Zealand White rabbits
  • Formulation: PBS (pH7.2)
  • Dosages: 10 or 25 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro Water 20 mg/mL (195.9 mM)
DMSO 8 mg/mL (78.36 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 102.09
Formula

C3H6N2O2

CAS No. 339-72-0
Storage powder
in solvent
Synonyms Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Transferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID