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PARP14 Selective Inhibitors

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S8992	RBN012759	RBN012759 is a potent and selective inhibitor of PARP14 with IC50 of <3 nM and 5 nM for human catalytic domain and mouse catalytic domain, respectively. RBN012759 contributes to anti-tumor immune response.	Selective	human PARP14, IC50: <3 nM; mouse PARP14, IC50: 5 nM
S0732	GeA-69	GeA-69 is a cell-permeable, selective allosteric inhibitor targeting macrodomain 2 (MD2) of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) with Kd of 860 nM.	Selective	PARP14-MD2, Kd: 860 nM