PARP14 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S8992 RBN012759

RBN012759 is a potent and selective inhibitor of PARP14 with IC50 of <3 nM and 5 nM for human catalytic domain and mouse catalytic domain, respectively. RBN012759 contributes to anti-tumor immune response.

Selective mouse PARP14, IC50: 5 nM; human PARP14, IC50: <3 nM
S0732 GeA-69

GeA-69 is a cell-permeable, selective allosteric inhibitor targeting macrodomain 2 (MD2) of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) with Kd of 860 nM.

Selective PARP14-MD2, Kd: 860 nM