Talazoparib (BMN 673)

Catalog No.S7048 Synonyms: LT-673

Talazoparib (BMN 673) Chemical Structure

Molecular Weight(MW): 380.35

Talazoparib (BMN 673) is a novel PARP inhibitor with IC50 of 0.57 nM for PARP1 in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3.

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4 Customer Reviews

  • Western blot assessment of effects on PAR, PARP, and dsDNA breaks mediated by IMMU-132 plus PARPi in TNBC tumor lines. Cells were plated overnight in 6-well plates before the addition of chemotherapeutics. After a 24-hour incubation, cells were harvested and cell lysates resolved and transferred for Western analysis as described in Materials and Methods. PAR and FL-PARP levels were determined on the same gel. Assessment of dsDNA breaks (p-H2A.X) was calculated as ratios relative to untreated control (Unt) normalized to b-actin protein loading control (Dp-H2A.X). B, HCC1806 cells exposed to rucaparib (Ruc) and IMMU-132 or to (C) talazoparib (Tala) and IMMU-132.

    Clin Cancer Res, 2017, 23(13):3405-3415. Talazoparib (BMN 673) purchased from Selleck.

    PARP inhibition prevents adhesion to and migration of monocytes across BMVEC monolayers preserving the barrier. Primary human monocytes were treated for 24 h with PARPi (AIQ, olaparib, EB47, talazoparib), calcein-labeled, washed, and then added to BMVEC monolayers (untreated or treated for 24 h with TNFα). Treatments were removed prior to the addition of monocytes. Adhesion to (a) and migration of (b) monocytes across blood-brain barrier models were measured and are presented as fold difference compared to TNFα-only control (mean ± SEM) for each treatment from at least quadruplicate determinations, which was assigned a value of 1 (7600 relative fluorescent units for adhesion or equivalent to 37 migrated cells). *P < 0.05, **P < 0.01 indicate significance vs. non-treated. TEER, an indicator of barrier integrity, was continuously measured in BMVEC monolayers treated with or without TNFα following the addition of primary human monocytes that had been treated with PARPi.

    J Neuroinflammation, 2016, 13(1):254.. Talazoparib (BMN 673) purchased from Selleck.

  • BT-549 cells reconstituted with Vet, WT, 336* or PTEN WT HP1aKD were treated with BMN673. Relative cell viability was determined by MTT assay. The results were presented as mean of 3 independent experiments. Error bars indicate s.d.

    Cell Cycle, 2015, 14(14): 2323-32. Talazoparib (BMN 673) purchased from Selleck.

    We treated the FA defective and control lung cancer cell lines H1299D2-down/H1299E and A549D2 down/A549E with BMN673 (0.5 µM). MTT assay was used for the cell viability analysis and an averaged absorbance was recorded 24, 48 and 72 h post treatment.

    Front Oncol, 2014, 4: 368. Talazoparib (BMN 673) purchased from Selleck.

Purity & Quality Control

Choose Selective PARP Inhibitors

Biological Activity

Description Talazoparib (BMN 673) is a novel PARP inhibitor with IC50 of 0.57 nM for PARP1 in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3.
Features Most potent and selective PARPi reported thus far.
Targets
PARP1 [1]
(Cell-free assay)
0.57 nM
In vitro

BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. BMN 673 selectively kills cancer cells with BRCA-1 or BRCA-2 mutations. BMN 673 demonstrates single-agent cytotoxicityin BRCA-1 mutant (MX-1, IC50 = 0.3 nM) and BRCA-2 mutant cells (Capan-1, IC50 = 5 nM). In contrast, in MRC-5 normal human fibroblastand other tumor cell lines with wild-type BRCA-1 and BRCA-2 genes, IC50 of BMN 673 ranges between 90 nM and 1.9 μM. [1] In cultured human cancer cells, BMN 673 also significantly enhances the cytotoxic efficacy of both Temozolomide and SN-38. Off-target molecular screening did not identify significant non-specific activity for this class of PARP inhibitors. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BR5FVB1-Akt NF\vOppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvtc2QxNjFvMUCwJI5O NEfKfIczPC92OD:3NkBp M4rvdYlvcGmkaYTzJINmdGxicILvcIln\XKjdHnvckBld3OnIHTldIVv\GWwdHz5 NWLa[2MxOjZyNEe2PVc>
BR5FVB1-Akt NUXqWIJESXCxcITvd4l{KEG|c3H5 MWCwMlEuOTByIH7N MXi3NkBp Mm\DbY5lfWOnczDhdI9xfG:|aYO= NG\zdYozPjB2N{[5Oy=>
Capan-1 NVX3UGozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7Vc5pEUUN3ME2xOk4x6oDLwsJihKk2NjUkgJpCuW3DqA>? M{LTT|I2QDZ2NUmw
MIA PaCa-2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTV6LkKz5qCKyrIkgJm4MlHjiIoEtV5CpC=> NYi0WYREOjV6NkS1PVA>
RD NUfFbG9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[1RYdyUUN3ME24Mlchdk1? NGPmeZozPTJ4M{WzPS=>
Rh41 MnO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrrXJlKSzVyPUiuNUBvVQ>? MXSyOVI3OzV|OR?=
Rh18 NW\IOWlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX60ZVU6UUN3ME20Mlkhdk1? NXXYXHVjOjV{NkO1N|k>
Rh30 NVfY[I1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTNzLkGgcm0> MVKyOVI3OzV|OR?=
BT-12 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n0VWlEPTB-4pEJNUwxODBibl2= MUGyOVI3OzV|OR?=
CHLA-266 Mlr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XqZWlEPTB-4pEJNUwxODBibl2= NH7G[FczPTJ4M{WzPS=>
TC-71 M3\lSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojnTWM2OD1|Lkegcm0> M3\5Z|I2OjZ|NUO5
CHLA-9 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUS1eIsxUUN3ME24MlIhdk1? MYOyOVI3OzV|OR?=
CHLA-10 MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;TTWM2OD14Nz64JI5O NW\XOphCOjV{NkO1N|k>
CHLA-258 M3uzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom1TWM2OD12Lk[gcm0> MmW2NlUzPjN3M{m=
SJ-GBM2 NILEblFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrhV2FZUUN3ME2xOk4zKG6P MV2yOVI3OzV|OR?=
NB-1643 NFvwdYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnoXotKSzVyPUG4MlQhdk1? MXmyOVI3OzV|OR?=
NB-EBc1 NVPReJdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTJ3Lkigcm0> Mlz6NlUzPjN3M{m=
CHLA-90 M1z1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXGWJhRUUN3ME9ihKkyNDByMDDuUS=> NXX1RmJmOjV{NkO1N|k>
CHLA-136 MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme4TWM2OD1zND6yJI5O MWKyOVI3OzV|OR?=
NALM-6 NYT2PYdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfscYNKSzVyPUS5JI5O MmS3NlUzPjN3M{m=
COG-LL-317 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTlwNDDuUS=> MlG2NlUzPjN3M{m=
RS4;11 MmTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYOyW3duUUN3ME21Nk43KG6P MViyOVI3OzV|OR?=
MOLT-4 Mn3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTF4Lk[gcm0> M2nzTVI2OjZ|NUO5
CCRF-CEM NFvBU3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rURWlEPTB;Nkm3MlMhdk1? NEKzdWIzPTJ4M{WzPS=>
Kasumi-1 MkfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTd6Nj6yJI5O NGDRZYEzPTJ4M{WzPS=>
Karpas-299 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX6PXlKSzVyPUe1Mlchdk1? MlnZNlUzPjN3M{m=
Ramos-RA1 MniwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL4TWM2OD14OD6zJI5O MV2yOVI3OzV|OR?=
DT40 Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTRibl2= NWPsb4Y6OjR|NU[4NVM>
DU145 MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLqTWM2OD1zMTDuUS=> MVmyOFM2PjhzMx?=
H209 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTFwNzDuUS=> M3XDU|I1ODd5M{Ww
H1048 M4nGdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJwMjDuUS=> MnfYNlQxPzd|NUC=
H524 Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDrTWM2OD1|LkGgcm0> M2DxZ|I1ODd5M{Ww
H1930 M{f3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLWSm1wUUN3ME20MlEhdk1? MUWyOFA4PzN3MB?=
H69 NGHaUmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDu[JVzUUN3ME21MlIhdk1? Mn:3NlQxPzd|NUC=
H2081 NG\HXoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHRc29KSzVyPU[uN{BvVQ>? MWGyOFA4PzN3MB?=
H2107 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2SzWGlEPTB;Nz6zJI5O NFTsdIszPDB5N{O1NC=>
H1092 MnTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{izZWlEPTB;OD65JI5O MlP4NlQxPzd|NUC=
DMS-79 NEjjOmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1i1WGlEPTB;OT6zJI5O NVrJPG1MOjRyN{ezOVA>
H446 NV3odmhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTF|IH7N NEfSNnQzPDB5N{O1NC=>
COR-L279 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTF3IH7N M3TKOlI1ODd5M{Ww

... Click to View More Cell Line Experimental Data

In vivo In rat pharmacokinetic studies, BMN 673 displays >50% oralbioavailability and pharmacokinetic properties that enable singledaily dosing. In MX-1 xenograft tumor model studies, daily oral dosingof BMN 673 significantly enhances the antitumor effects ofcytotoxic therapies in a dose-dependent manner. [2]

Protocol

Animal Research:

[2]

+ Expand
  • Animal Models: MX-1 model (BRCA-1 deficient)
  • Formulation: --
  • Dosages: 0.33 mg/kg/day, once daily
  • Administration: Oral
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 38 mg/mL warmed (99.9 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 380.35
Formula

 

C19H14F2N6O
 
CAS No. 1207456-01-6
Storage powder
in solvent
Synonyms LT-673

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03426254 Enrolling by invitation Advanced or Recurrent Solid Tumors|Breast Neoplasm Center Trials & Treatment|BioGene Pharmaceutical February 8 2018 Phase 1
NCT02997163 Recruiting Advanced Solid Tumors Pfizer|Medivation Inc. February 8 2017 Phase 1
NCT02921919 Recruiting Cancer Pfizer|Medivation Inc. November 8 2016 Phase 2
NCT03377556 Recruiting ATM Gene Mutation|ATR Gene Mutation|BARD1 Gene Mutation|BRCA1 Gene Mutation|BRCA2 Gene Mutation|BRIP1 Gene Mutation|CHEK1 Gene Mutation|CHEK2 Gene Mutation|FANCA Gene Mutation|FANCC Gene Mutation|FANCD2 Gene Mutation|FANCF Gene Mutation|FANCM Gene Mutation|NBN Gene Mutation|PALB2 Gene Mutation|RAD51 Gene Mutation|RAD51B Gene Mutation|RAD54L Gene Mutation|Recurrent Squamous Cell Lung Carcinoma|RPA1 Gene Mutation|Stage IV Squamous Cell Lung Carcinoma AJCC v7 Southwest Oncology Group|National Cancer Institute (NCI) February 7 2017 Phase 2
NCT03077607 Completed Advanced Solid Tumors Pfizer|Medivation Inc. November 7 2016 Phase 1
NCT03148795 Recruiting Prostate Cancer Pfizer|Medivation Inc. July 4 2017 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    Which solvent do you recommend to dilute the inhibitor for in vivo study in mice?

  • Answer:

    BMN673 (S7048) can be dissolved in vehicle (10% DMAc, 6% Solutol, and 84% PBS) according to the paper: http://clincancerres.aacrjournals.org/content/19/18/5003.full. Quote from Method and Material section "Xenograft experiments: BMN 673 (various doses as indicated), or vehicle (10% DMAc, 6% Solutol, and 84% PBS) was administered by oral gavage"

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID