Home Metabolism PPAR antagonist DG172 dihydrochloride

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DG172 dihydrochloride PPAR antagonist

Cat.No.S0531

DG-172 dihydrochloride is a novel PPARβ/δ-selective antagonist with the IC50 of 27 nM.
DG172 dihydrochloride PPAR antagonist Chemical Structure

Chemical Structure

Molecular Weight: 455.22

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Quality Control

Batch: S053101 DMSO]91 mg/mL]false]Water]44 mg/mL]false]Ethanol]23 mg/mL]false Purity: 99.17%
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99.17

Solubility

In vitro
Batch:

DMSO : 91 mg/mL (199.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 44 mg/mL

Ethanol : 23 mg/mL

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 455.22 Formula

C20H20BrN3.2ClH

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1361504-77-9 -- Storage of Stock Solutions

Synonyms N/A Smiles CN1CCN(CC1)C2=CC=C(C=C2)C=C(C#N)C3=CC=CC=C3Br.Cl.Cl

Mechanism of Action

Targets/IC50/Ki
PPARβ/δ
(in a competitive TR-FRET assay)
27 nM
In vitro

DG-172 dihydrochloride selectively inhibits the agonist-induced activity of PPARβ/δ, enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts. 
References

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