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Catalog No.S2798

1 publication

GW6471 Chemical Structure

CAS No. 880635-03-0 (436159-64-7 deprecated)

GW 6471 is a potent antagonist of PPARα with IC50 of 0.24 μM.

Selleck's GW6471 has been cited by 1 publication

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Biological Activity

Description GW 6471 is a potent antagonist of PPARα with IC50 of 0.24 μM.
PPARα [1]
(Cell-free assay)
0.24 μM
In vitro

GW6471 completely inhibits GW409544-induced activation of PPARα with IC50 of 0.24 μM. GW6471 at concentration ranging from 0.001-10 μM disrupts the interactions between PPAR and coactivator motifs derived from SRC-1 or CBP, but promotes the binding of the co-repressor motifs from SMRT or N-CoR. GW6471 adopts a U-shaped configuration and wraps around C276 of helix 3, destroys the integrity of the charge clamp but leaves sufficient space to accommodate the additional helical turn of the co-repressor motif in the PPAR/GW6471/SMRT complexes. [1] GW6471 at concentration of 10 μM significantly prevents cardiomyocyte differentiation and results in the reduced expression of cardiac sarcomeric proteins (ie α-actinin, troponin-T) and specific genes (ie α-MHC, MLC2v) in a time-dependent manner through inhibiting PPARα. [2]


Solubility (25°C)

In vitro DMSO 100 mg/mL (161.37 mM)
Ethanol 30 mg/mL (48.41 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 619.67


CAS No. 880635-03-0 (436159-64-7 deprecated)
Storage powder
in solvent
Synonyms N/A
Smiles CCC(=O)NCC(CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)NC(=CC(=O)C4=CC=C(C=C4)C(F)(F)F)C

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID