Home Metabolism -DNA Damage/DNA Repair PPAR PPARβ/δ Selective Inhibitors | Agonists | Antagonists

PPARβ/δ Selective Inhibitors | Agonists | Antagonists

  • PPARα
  • PPARβ/δ
  • PPARγ
  • PPARδ
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S0531 DG172 dihydrochloride DG-172 dihydrochloride is a novel PPARβ/δ-selective antagonist with the IC50 of 27 nM. Selective PPARβ/δ, IC50: 27 nM
S8020 GW0742 GW0742 is a potent and highly selective PPARβ/δ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ. Pan PPARδ, EC50: 1 nM
S8025 GSK3787 GSK3787 is a selective and irreversible antagonist of PPARδ with pIC50 of 6.6, with no measurable affinity for hPPARα or hPPARγ. Pan PPARδ, pIC50: 6.6
S8770 Lanifibranor (IVA-337) Lanifibranor (IVA-337) is a moderately potent and well balanced pan PPAR agonist with EC50 values of 1537 nM, 866 nM and 206 nM for hPPARα, hPPARδ and hPPARγ, respectively. Pan PPARδ, EC50: 866 nM
S7484 FH535 FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist. Pan
S3720 Elafibranor Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α(PPAR-alpha) and peroxisome proliferator-activated receptor-δ(PPAR-δ). It improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation. Pan