Home Metabolism HSP (HSP90) modulator TRC051384

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TRC051384 HSP (HSP90) modulator

Cat.No.S8305

TRC051384 is an inducer of heat shock protein 70 (HSP70) and potent anti-inflammatory agent.
TRC051384 HSP (HSP90) modulator Chemical Structure

Chemical Structure

Molecular Weight: 465.54

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S830501 DMSO]93 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.06%
99.06

Chemical Information, Storage & Stability

Molecular Weight 465.54 Formula

C25H31N5O4

 Storage (From the date of receipt) 3 years -20°C(in the dark) powder
CAS No. 867164-40-7 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C1COCCN1CCNC(=O)NC2=CC=C(C=C2)C(=O)C=CC3=NC(=CC=C3)N4CCOCC4

Solubility

In vitro
Batch:

DMSO : 93 mg/mL ( (199.76 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
HSP70 [1]
In vitro
TRC051384 is a compound that induces HSPA1A/B expression and subsequent Hsp70 production via heat shock factor-1 (HSF1) activation[2]. This compound increases HSP70B mRNA expression in both HeLa and primary mixed neuronal cells. Induction of HSP70 by this chemical involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity[1].
In vivo
Treatment with TRC051384 significantly reduces stroke associated neuronal injury and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. This compound significantly reduces infarct size, brain edema and improves neurological deficit[1]. It delays thrombus formation in WT mice, the tail bleeding time still being unaltered[2].
References

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