For research use only.

Catalog No.S8305

TRC051384 Chemical Structure

Molecular Weight(MW): 465.54

TRC051384 is an inducer of heat shock protein 70 (HSP70) and potent anti-inflammatory agent.

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Biological Activity

Description TRC051384 is an inducer of heat shock protein 70 (HSP70) and potent anti-inflammatory agent.
HSP70 [1]
In vitro

TRC051384 is a compound that induces HSPA1A/B expression and subsequent Hsp70 production via heat shock factor-1 (HSF1) activation[2]. TRC051384 increases HSP70B mRNA expression in both HeLa and primary mixed neuronal cells. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity[1].

In vivo Treatment with TRC051384 significantly reduces stroke associated neuronal injury and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. TRC051384 significantly reduces infarct size, brain edema and improves neurological deficit[1]. TRC051384 delays thrombus formation in WT mice, the tail bleeding time still being unaltered[2].


Cell Research:


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  • Cell lines: HeLa cell line (CCL-2, ATCC)
  • Concentrations: 6.25 and 12.5 μM
  • Incubation Time: 4 h
  • Method:

    Induction of HSP70B mRNA is carried out by treatment of cells with TRC051384 (6.25 and 12.5 μM) for 4 hours duration for HeLa cell line and total RNA is isolated. For all RNA samples, cDNAs are synthesized and expression of HSP70B mRNA along with expression of 18S rRNA is monitored by real-time PCR employing ABI 7000 system.

    (Only for Reference)
Animal Research:


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  • Animal Models: Sprague Dawley male rats
  • Dosages: 4.5 mg/kg and 9 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL (199.76 mM)
Ethanol 5 mg/mL (10.74 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54


CAS No. 867164-40-7
Storage 3 years -20°C(in the dark) powder
2 years -80°C(in the dark) in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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HSP (HSP90) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID