For research use only.

Catalog No.S8312

1 publication

NSC228155 Chemical Structure

Molecular Weight(MW): 290.25

NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.

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Selleck's NSC228155 has been cited by 1 publication

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Biological Activity

Description NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.
EGFR [2]
KIX-KID interaction [3]
0.36 μM
In vitro

NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II[1]. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells[2]. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells[3].


Cell Research:[1]
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  • Cell lines: MDA MB468 cells
  • Concentrations: 100 μM
  • Incubation Time: 15 min
  • Method: MDA MB468 cells serum-starved overnight are pre-incubated (or not) with 10 μM AG1478 or 2 μM PD 153035 for 90 min and then, where indicated, incubated with 100 μM NSC 228155 or CN 009543V or 150 ng/ml EGF or vehicle (0.2% DMSO) for 15 min. Proteins are blotted to nitrocellulose membrane and analyzed with biotinylated anti-pTyr P100, anti-pEGFR Y1068 and anti-EGFR (epitope in cytoplasmic region) antibodies.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 15 mg/mL (51.67 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 290.25


CAS No. 113104-25-9
Storage powder
in solvent
Synonyms N/A
Smiles [O-][N+](=O)C1=CC=C(SC2=CC=CC=[N+]2[O-])C3=NON=C13

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID