Home Protein Tyrosine Kinase -Angiogenesis -JAK/STAT EGFR ErbB3 Inhibitors

ErbB3 Inhibitors

  • EGFR/ErbB1
  • HER2/ErbB2
  • ErbB3
  • ErbB4
  • mutant EGFR
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2192 Sapitinib (AZD8931) Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2. Pan ErbB3, IC50: 4 nM