Catalog No.S4667 Synonyms: Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural
Molecular Weight(MW): 270.8
Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.
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|Description||Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.|
Lidocaine above 1.25 g/l reduces cellular viability and triggers apoptosis in HCE cells in a time- and dose-dependent manner. Lidocaine-induced apoptosis is caspase dependent and may be related to mitochondrial pathway. Lidocaine, at the level of tissue concentration under topical or local administration, also has a direct inhibitory effect on the activity of epidermal growth factor receptor (EGFR), which is a potential target for antiproliferation in cancer cells.
|In vivo||Intravenous administration of the local anaesthetic lidocaine has been used to treat neuropathic pain for several decades and significantly improves postoperative pain associated with complex spine surgery and cholecystectomy. It is well established that lidocaine used for regional anaesthesia blocks impulses in peripheral nerves by inhibiting voltage-gated sodium (Na+) channels. Intravenous lidocaine has an analgesic effect on mechanical noxious response, decreases the spinal noxious response induced by peripheral pinch stimuli and the frequency of spontaneous excitatory postsynaptic currents(EPSCs) without changing their amplitude. It has no effect on spontaneous inhibitory postsynaptic currents and produces an outward current in SG neurons.|
|In vitro||DMSO||54 mg/mL (199.4 mM)|
|Water||54 mg/mL (199.4 mM)|
|Ethanol||54 mg/mL (199.4 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03526874||Not yet recruiting||Chronic Migraine Headache|Episodic Migraine||Children''s Hospital of Philadelphia|National Institute of Neurological Disorders and Stroke (NINDS)||November 2018||Phase 3|
|NCT03667001||Not yet recruiting||Pain Postoperative||Miodrag Filipovic Prof. Dr. med.|Cantonal Hospital of St. Gallen||October 1 2018||Phase 3|
|NCT03566329||Recruiting||Craniotomy|Hypertension||Ahmed Mohamed ELbadawy|Kasr El Aini Hospital||July 10 2018||Phase 1|
|NCT03560349||Enrolling by invitation||Post-Dural Puncture Headache||University of Utah|University of Colorado Denver|University of California San Francisco|Duke University|Mayo Clinic|Harvard University||July 1 2018||Phase 2|
|NCT03484650||Not yet recruiting||Post Operative Pain||Carilion Clinic||June 1 2018||Phase 3|
|NCT03310970||Recruiting||Healthy||Nicole K Brogden|Long Island University|University of Iowa||March 7 2018||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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