Lidocaine hydrochloride

Catalog No.S4667 Synonyms: Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural

For research use only.

Lidocaine hydrochloride (Lidothesin, Lignocaine, Xyloneural) is an inhibitor of epidermal growth factor receptor (EGFR) and has antiproliferative effect on human tongue cancer cells. Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.

Lidocaine hydrochloride Chemical Structure

CAS No. 73-78-9

Selleck's Lidocaine hydrochloride has been cited by 1 Publication

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Biological Activity

Description Lidocaine hydrochloride (Lidothesin, Lignocaine, Xyloneural) is an inhibitor of epidermal growth factor receptor (EGFR) and has antiproliferative effect on human tongue cancer cells. Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.
Targets
EGFR [3]
()
In vitro

Lidocaine above 1.25 g/l reduces cellular viability and triggers apoptosis in HCE cells in a time- and dose-dependent manner. Lidocaine-induced apoptosis is caspase dependent and may be related to mitochondrial pathway[1]. Lidocaine, at the level of tissue concentration under topical or local administration, also has a direct inhibitory effect on the activity of epidermal growth factor receptor (EGFR), which is a potential target for antiproliferation in cancer cells[3].

In vivo Intravenous administration of the local anaesthetic lidocaine has been used to treat neuropathic pain for several decades and significantly improves postoperative pain associated with complex spine surgery and cholecystectomy. It is well established that lidocaine used for regional anaesthesia blocks impulses in peripheral nerves by inhibiting voltage-gated sodium (Na+) channels. Intravenous lidocaine has an analgesic effect on mechanical noxious response, decreases the spinal noxious response induced by peripheral pinch stimuli and the frequency of spontaneous excitatory postsynaptic currents(EPSCs) without changing their amplitude. It has no effect on spontaneous inhibitory postsynaptic currents and produces an outward current in SG neurons[2].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: Human Corneal Endothelial Cells
  • Concentrations: 0.15625–10.0 g/l
  • Incubation Time: 4-28 hr
  • Method: Cells at logarithmic phase are treated with lidocaine hydrochloride at concentrations (w/v) from 10 to 0.15625 g/l in step dilutions. HCE cells without lidocaine treatment are used as controls. The morphology and growing status of the cells are monitored every 4 hr.
Animal Research:[2]
  • Animal Models: Male Wistar rats
  • Dosages: 1, 3, 10 mg/kg
  • Administration: i.v.

Solubility (25°C)

In vitro

DMSO 54 mg/mL
(199.4 mM)
Water 54 mg/mL
(199.4 mM)
Ethanol '54 mg/mL

Chemical Information

Molecular Weight 270.8
Formula

C14H22N2O.HCl

CAS No. 73-78-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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