Chlorpromazine

Catalog No.S5749 Batch:S574904

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Technical Data

Formula

C17H19ClN2S
Molecular Weight 318.86 CAS No. 50-53-3
Solubility (25°C)* In vitro DMSO 65 mg/mL (203.85 mM)
Ethanol 64 mg/mL (200.71 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. This compound inhibits 5-HT(2A) receptor and dopamine D2 in vitro. It also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.
In vitro

Chlorpromazine exerts a mild decrease in sEV uptake in only one MM cell line, indicating that the uptake of BMSC-derived sEVs by suspension MM cells may not rely on this compound-targeted receptors.[1]
In vivo

Chlorpromazine suppresses the growth of endometrial cancer (EC) tumors in vivo at a low dose with no signs of toxicity.[2]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    MM1S cells, RPMI 8226, U266, H929 cells

  • Concentrations

    5, 10, 20 μM

  • Incubation Time

    30 min for MM1S cells, 4.5 h for RPMI 8226, U266, H929 cells

  • Method

    MM1S cells pre-treated with heparin, cytochalasin D (Cyto D), dynasore, genistein, or chlorpromazine (CPZ) at the indicated concentrations for 30 min are cultured with 50 μg/mL DID-labeled BMSC-derived sEVs for another 4 h. The mean fluorescence intensity of DID in these cells is determined using flow cytometry. RPMI 8226, U266, or H929 cells are treated with heparin, Cyto D, dynasore, genistein, or this compound at the indicated concentration for 4.5 h in the absence of sEVs and their cell viability is measured.
Animal Study:

[2]
  • Animal Models

    female BALB/c nude mice

  • Dosages

    3 or 12 mg/kg

  • Administration

    i.p.

References

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797667/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087176/

Selleck's Chlorpromazine Has Been Cited by 51 Publications

Crosstalk between chromatin state and ATM signalling in DNA damage-induced transcription stress [ EMBO J, 2025, 10.1038/s44318-025-00537-7] PubMed: 40859031
KCNN4-mediated potassium ion efflux maintains mitochondrial functions leading to platelet biogenesis [ J Thromb Haemost, 2025, 23(9):2926-2943] PubMed: 40412718
Glycerophospholipid metabolism licenses IgE-mediated mast cell degranulation [ Cell Rep, 2025, 44(6):115742] PubMed: 40397574
A microfluidic platform for the co-culturing of microtissues with continuously recirculating suspension cells [ Microsyst Nanoeng, 2025, 11(1):184] PubMed: 41073406
Protective effect of norepinephrine, dopamine and N-methyldopamine against chemically-induced oxidative ferroptosis in HT22 neuronal cells: Protein disulfide isomerase as a mechanistic target for protection [ Free Radic Biol Med, 2025, 237:631-649] PubMed: 40456499
SFTSV utilizes AXL/GAS6 for entry via PI3K-PLC-dependent macropinocytosis activated by AXL-kinase [ J Virol, 2025, 99(9):e0022125] PubMed: 40853130
Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles [ J Biol Chem, 2025, 301(3):108255] PubMed: 39909378
RfeA from Streptococcus suis serotype 2 triggers NLRP3/Caspase-1-dependent pyroptosis leading to blood-brain barrier disruption [ Vet Res, 2025, 56(1):184] PubMed: 40999536
Cholesterol-rich lipid rafts mediate endocytosis as a common pathway for respiratory syncytial virus entry into different host cells [ Microbiol Spectr, 2025, 13(9):e0119225] PubMed: 40742151
Dual-cardiotoxicity evaluation of torsadogenic risk drugs using human iPSC-derived cardiomyocytes [ Biochem Biophys Res Commun, 2025, 786:152756] PubMed: 41043280

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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