ATR Selective Inhibitors
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM, 8-fold selectivity over mTOR.
|Selective||ATR, IC50: 5 nM|
VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.
|Selective||ATR, Ki: 13 nM; ATR, IC50: 26 nM|
ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
|Selective||ATR, IC50: 14 nM|
VE-822 is an ATR inhibitor with IC50 of 19 nM.
|Selective||ATR, IC50: 19 nM|
|S1009||BEZ235 (NVP-BEZ235, Dactolisib)||
BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively. Inhibits ATR with IC50 of 21 nM, whileshown to be a poor inhibitor to Akt and PDK1. Phase 2.
|Selective||ATR, IC50: 21 nM|
|S3600||Schisandrin B (Sch B)||
Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill.
|Selective||ATR, IC50: 7.25 μM|
Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.
|Pan||ATR, EC50: 35 nM|
CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.
|Pan||ATR, IC50: 200 nM|
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM.
|Pan||ATR, IC50: 1.8 μM|