ATM Selective Inhibitors | Activators
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.
|Selective||ATM, IC50: 6.3 nM|
|S1092||KU-55933 (ATM Kinase Inhibitor)||
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
|Selective||ATM, IC50: 12.9 nM|
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM.
|Selective||ATM, IC50: 150 nM|
CP-466722 is a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.
|Selective||ATM, IC50: 410 nM|
Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.
Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.
|Pan||ATM, EC50: 28 nM|
CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.
|Pan||ATM, IC50: 200 nM|
ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
|Pan||ATM, IC50: 545 nM|
VE-822 is an ATR inhibitor with IC50 of 19 nM.
|Pan||ATM, IC50: 34 μM|
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