Histone Acetyltransferase

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S7152 C646 <1 mg/mL 13 mg/mL <1 mg/mL
S1848 Curcumin <1 mg/mL 73 mg/mL <1 mg/mL
S8740 A-485 <1 mg/mL 100 mg/mL 100 mg/mL
S7582 Anacardic Acid <1 mg/mL 69 mg/mL 69 mg/mL
S7641 Remodelin <1 mg/mL 72 mg/mL <1 mg/mL
S7476 MG149 <1 mg/mL 68 mg/mL 68 mg/mL
Catalog No. Information Product Use Citations Product Validations


C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases.



Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.



A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets.


Anacardic Acid

Anacardic Acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.



Remodelin is a potent acetyl-transferase NAT10 inhibitor.


Ginkgolic Acid

Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).



MG149 is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.