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Histone Acetyltransferase

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Histone Acetyltransferase Signaling Pathway Map

Histone Acetyltransferase Signaling Pathways

Isoform-selective Inhibitors

Histone Acetyltransferase Products

All (22)
Histone Acetyltransferase Inhibitors (19)
Histone Acetyltransferase Antibodies (2)
Histone Acetyltransferase Activator (1)
New Histone Acetyltransferase Products

Catalog No.	Product Name	Information	Product Use Citations
E0146^New	PF-9363 (CTx-648)	PF-9363 (CTx-648) is a potent and selective KAT6A/6B inhibitor with Ki of 0.41 nM and 1.2 nM for KAT6A and KAT6B, respectively. PF-9363 displays potent anti-tumor activity in ER+ breast cancer models.
S1161	Histone Acetyltransferase Inhibitor II	Histone Acetyltransferase Inhibitor II (HAT Inhibitor II, compound 2c) is a potent, selective and cell-permeable p300 histone acetyltransferase (HAT) inhibitor with IC50 of 5 μM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells.
S1242	CPTH2	CPTH2 is a potent histone acetyltransferase (HAT) inhibitor modulating Gcn5p network. CPTH2 induces apoptosis and decreases the invasiveness of a ccRCC cell line through the inhibition of KAT3B.	Transl Oncol, 2021, 14(11):101196
S1848	Curcumin	Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.	Adv Sci (Weinh), 2021, e2103360 Front Immunol, 2021, 12:656242 Aging (Albany NY), 2021, 13(10):13968-14000
S2951	P300/CBP-IN-3	P300/CBP-IN-3 is an inhibitor of p300/CBP histone acetyltransferase.
S6655	WM-8014	WM-8014 is a highly potent inhibitor of histone acetyltransferase KAT6A with an IC50 of 8 nM.
S6886	1-Aminobenzotriazole	1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).
S7152	C646	C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a K_i of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases. C646 induces cell cycle arrest, apoptosis and autophagy.	Hepatology, 2021, 10.1002/hep.32245 Cancer Lett, 2021, 513:36-49 Cancer Lett, 2021, S0304-3835(21)00532-2
S7256	SGC-CBP30	SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.	Nature, 2021, 10.1038/s41586-021-04116-8 Immunity, 2021, S1074-7613(21)00222-3 Sci Adv, 2021, 7(36):eabf9975
S7476	MG149	MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.	Biomolecules, 2021, 11(5)658 Mol Cell Endocrinol, 2021, 537:111425 bioRxiv, 2021, 2021.04.21.440833
S7582	Anacardic Acid	Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.	Hepatology, 2021, 10.1002/hep.32245 Oncogene, 2020, 39(18):3754-3773 Free Radic Biol Med, 2020, 10.1016/j.freeradbiomed.2020.01.016
S7641	Remodelin hydrobromide	Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.	Transl Oncol, 2020, 16;13(8):100783 Mol Cell Biochem, 2020, 10.1007/s11010-020-03776-w Cell Rep, 2019, 29(7):2078-2091.e5
S8190	CPI-637	CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM and 0.051μM for CBP and EP300 respectively in TR-FRET assay. It is highly selective against other bromodomains, displaying substantial biochemical activity only against BRD9.	Acta Pharmacol Sin, 2019, 10.1038/s41401-019-0237-5
S8740	A-485	A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets.	Mol Cell, 2021, S1097-2765(21)00051-4 Elife, 2021, 10e65654 Cell Death Dis, 2021, 12(5):419
S8776	WM-1119	WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively.	Theranostics, 2021, 11(13):6278-6292 Biochem Biophys Res Commun, 2021, 585:185-190 Theriogenology, 2021, 159:140-146
S9432	Ginkgolic Acid	Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).	Neurochem Res, 2021, 10.1007/s11064-021-03260-x
S9445	Ginkgolic Acid (C13:0)	Ginkgolic Acid (C13:0) is a natural anticariogenic agent in Ginkgo biloba L. that exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. Ginkgolic acid is a potent sumoylation inhibitor and reported to inhibit histone acetylation transferase (HAT).
S9648	NEO2734	NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of p300/CBP and BET bromodomain with IC50 of both <30 nM.
S9805^New	WM-3835	WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
A5041	ATF2 Rabbit Recombinant mAb	ATF2 Antibody detects endogenous levels of total ATF2.
A5083	ATF1 Rabbit Recombinant mAb	ATF1 Rabbit Recombinant mAb detects endogenous levels of ATF1.
S0022	YF-2	YF-2 is a highly selective, blood-brain-barrier permeable activator of histone acetyltransferase (HAT). In In vitro assays, YF-2 has activity versus CBP, PCAF, and GCN5 with EC50 of 2.75 μΜ, 29.04 μΜ and 49.3 μΜ, respectively. YF-2 also increases p300 activity.
E0146^New	PF-9363 (CTx-648)	PF-9363 (CTx-648) is a potent and selective KAT6A/6B inhibitor with Ki of 0.41 nM and 1.2 nM for KAT6A and KAT6B, respectively. PF-9363 displays potent anti-tumor activity in ER+ breast cancer models.
S1161	Histone Acetyltransferase Inhibitor II	Histone Acetyltransferase Inhibitor II (HAT Inhibitor II, compound 2c) is a potent, selective and cell-permeable p300 histone acetyltransferase (HAT) inhibitor with IC50 of 5 μM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells.
S1242	CPTH2	CPTH2 is a potent histone acetyltransferase (HAT) inhibitor modulating Gcn5p network. CPTH2 induces apoptosis and decreases the invasiveness of a ccRCC cell line through the inhibition of KAT3B.	Transl Oncol, 2021, 14(11):101196
S1848	Curcumin	Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.	Adv Sci (Weinh), 2021, e2103360 Front Immunol, 2021, 12:656242 Aging (Albany NY), 2021, 13(10):13968-14000
S2951	P300/CBP-IN-3	P300/CBP-IN-3 is an inhibitor of p300/CBP histone acetyltransferase.
S6655	WM-8014	WM-8014 is a highly potent inhibitor of histone acetyltransferase KAT6A with an IC50 of 8 nM.
S6886	1-Aminobenzotriazole	1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).
S7152	C646	C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a K_i of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases. C646 induces cell cycle arrest, apoptosis and autophagy.	Hepatology, 2021, 10.1002/hep.32245 Cancer Lett, 2021, 513:36-49 Cancer Lett, 2021, S0304-3835(21)00532-2
S7256	SGC-CBP30	SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.	Nature, 2021, 10.1038/s41586-021-04116-8 Immunity, 2021, S1074-7613(21)00222-3 Sci Adv, 2021, 7(36):eabf9975
S7476	MG149	MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.	Biomolecules, 2021, 11(5)658 Mol Cell Endocrinol, 2021, 537:111425 bioRxiv, 2021, 2021.04.21.440833
S7582	Anacardic Acid	Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.	Hepatology, 2021, 10.1002/hep.32245 Oncogene, 2020, 39(18):3754-3773 Free Radic Biol Med, 2020, 10.1016/j.freeradbiomed.2020.01.016
S7641	Remodelin hydrobromide	Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.	Transl Oncol, 2020, 16;13(8):100783 Mol Cell Biochem, 2020, 10.1007/s11010-020-03776-w Cell Rep, 2019, 29(7):2078-2091.e5
S8190	CPI-637	CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM and 0.051μM for CBP and EP300 respectively in TR-FRET assay. It is highly selective against other bromodomains, displaying substantial biochemical activity only against BRD9.	Acta Pharmacol Sin, 2019, 10.1038/s41401-019-0237-5
S8740	A-485	A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets.	Mol Cell, 2021, S1097-2765(21)00051-4 Elife, 2021, 10e65654 Cell Death Dis, 2021, 12(5):419
S8776	WM-1119	WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively.	Theranostics, 2021, 11(13):6278-6292 Biochem Biophys Res Commun, 2021, 585:185-190 Theriogenology, 2021, 159:140-146
S9432	Ginkgolic Acid	Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).	Neurochem Res, 2021, 10.1007/s11064-021-03260-x
S9445	Ginkgolic Acid (C13:0)	Ginkgolic Acid (C13:0) is a natural anticariogenic agent in Ginkgo biloba L. that exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. Ginkgolic acid is a potent sumoylation inhibitor and reported to inhibit histone acetylation transferase (HAT).
S9648	NEO2734	NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of p300/CBP and BET bromodomain with IC50 of both <30 nM.
S9805^New	WM-3835	WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
A5041	ATF2 Rabbit Recombinant mAb	ATF2 Antibody detects endogenous levels of total ATF2.
A5083	ATF1 Rabbit Recombinant mAb	ATF1 Rabbit Recombinant mAb detects endogenous levels of ATF1.
S0022	YF-2	YF-2 is a highly selective, blood-brain-barrier permeable activator of histone acetyltransferase (HAT). In In vitro assays, YF-2 has activity versus CBP, PCAF, and GCN5 with EC50 of 2.75 μΜ, 29.04 μΜ and 49.3 μΜ, respectively. YF-2 also increases p300 activity.
E0146^New	PF-9363 (CTx-648)	PF-9363 (CTx-648) is a potent and selective KAT6A/6B inhibitor with Ki of 0.41 nM and 1.2 nM for KAT6A and KAT6B, respectively. PF-9363 displays potent anti-tumor activity in ER+ breast cancer models.
S9805^New	WM-3835	WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.