GNAT Selective Inhibitors | Activators

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7641 Remodelin hydrobromide

Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.

Selective
S6886 1-Aminobenzotriazole

1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).

Selective
s7582 Anacardic Acid

Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.

Pan PCAF, IC50: 5 μM
S0022 YF-2

YF-2 is a highly selective, blood-brain-barrier permeable activator of histone acetyltransferase (HAT). In In vitro assays, YF-2 has activity versus CBP, PCAF, and GCN5 with EC50 of 2.75 μΜ, 29.04 μΜ and 49.3 μΜ, respectively. YF-2 also increases p300 activity.

Pan PCAF, EC50: 29.04 μM; GCN5, EC50: 49.3 μM